PUF4_YEAST - dbPTM
PUF4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUF4_YEAST
UniProt AC P25339
Protein Name Pumilio homology domain family member 4
Gene Name PUF4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 888
Subcellular Localization
Protein Description Is not essential for haploid growth, but may affect diploid formation..
Protein Sequence MSTKGLKEEIDDVPSVDPVVSETVNSALEQLQLDDPEENATSNAFANKVSQDSQFANGPPSQMFPHPQMMGGMGFMPYSQMMQVPHNPCPFFPPPDFNDPTAPLSSSPLNAGGPPMLFKNDSLPFQMLSSGAAVATQGGQNLNPLINDNSMKVLPIASADPLWTHSNVPGSASVAIEETTATLQESLPSKGRESNNKASSFRRQTFHALSPTDLINAANNVTLSKDFQSDMQNFSKAKKPSVGANNTAKTRTQSISFDNTPSSTSFIPPTNSVSEKLSDFKIETSKEDLINKTAPAKKESPTTYGAAYPYGGPLLQPNPIMPGHPHNISSPIYGIRSPFPNSYEMGAQFQPFSPILNPTSHSLNANSPIPLTQSPIHLAPVLNPSSNSVAFSDMKNDGGKPTTDNDKAGPNVRMDLINPNLGPSMQPFHILPPQQNTPPPPWLYSTPPPFNAMVPPHLLAQNHMPLMNSANNKHHGRNNNSMSSHNDNDNIGNSNYNNKDTGRSNVGKMKNMKNSYHGYYNNNNNNNNNNNNNNNSNATNSNSAEKQRKIEESSRFADAVLDQYIGSIHSLCKDQHGCRFLQKQLDILGSKAADAIFEETKDYTVELMTDSFGNYLIQKLLEEVTTEQRIVLTKISSPHFVEISLNPHGTRALQKLIECIKTDEEAQIVVDSLRPYTVQLSKDLNGNHVIQKCLQRLKPENFQFIFDAISDSCIDIATHRHGCCVLQRCLDHGTTEQCDNLCDKLLALVDKLTLDPFGNYVVQYIITKEAEKNKYDYTHKIVHLLKPRAIELSIHKFGSNVIEKILKTAIVSEPMILEILNNGGETGIQSLLNDSYGNYVLQTALDISHKQNDYLYKRLSEIVAPLLVGPIRNTPHGKRIIGMLHLDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
107PhosphorylationPTAPLSSSPLNAGGP
CCCCCCCCCCCCCCC		29.9928889911
122PhosphorylationPMLFKNDSLPFQMLS
CCCCCCCCCCHHHHC		47.5430377154
129PhosphorylationSLPFQMLSSGAAVAT
CCCHHHHCCCCEEEC		22.7629136822
130PhosphorylationLPFQMLSSGAAVATQ
CCHHHHCCCCEEECC		28.6129136822
136PhosphorylationSSGAAVATQGGQNLN
CCCCEEECCCCCCCC		22.5829136822
150PhosphorylationNPLINDNSMKVLPIA
CCCCCCCCCCEEEEC		23.8929136822
189PhosphorylationTLQESLPSKGRESNN
HHHHHCCCCCCCCCC		53.7028889911
199PhosphorylationRESNNKASSFRRQTF
CCCCCCCHHHHHHHH		31.4524961812
200PhosphorylationESNNKASSFRRQTFH
CCCCCCHHHHHHHHH		27.8621440633
205PhosphorylationASSFRRQTFHALSPT
CHHHHHHHHHHCCHH		18.6422369663
210PhosphorylationRQTFHALSPTDLINA
HHHHHHCCHHHHHHH		26.9122369663
212PhosphorylationTFHALSPTDLINAAN
HHHHCCHHHHHHHHC		39.8122369663
222PhosphorylationINAANNVTLSKDFQS
HHHHCCCCCCHHHHH		27.6919779198
224PhosphorylationAANNVTLSKDFQSDM
HHCCCCCCHHHHHHH		22.3229688323
229PhosphorylationTLSKDFQSDMQNFSK
CCCHHHHHHHHHHHH		34.7421440633
241PhosphorylationFSKAKKPSVGANNTA
HHHCCCCCCCCCCCC		41.9019823750
247PhosphorylationPSVGANNTAKTRTQS
CCCCCCCCCCCCEEE		29.3719823750
250PhosphorylationGANNTAKTRTQSISF
CCCCCCCCCEEEEEC		36.1622369663
252PhosphorylationNNTAKTRTQSISFDN
CCCCCCCEEEEECCC		31.7222369663
254PhosphorylationTAKTRTQSISFDNTP
CCCCCEEEEECCCCC		21.4222369663
256PhosphorylationKTRTQSISFDNTPSS
CCCEEEEECCCCCCC		31.6222369663
260PhosphorylationQSISFDNTPSSTSFI
EEEECCCCCCCCCCC		26.7921440633
262PhosphorylationISFDNTPSSTSFIPP
EECCCCCCCCCCCCC		44.1828132839
263PhosphorylationSFDNTPSSTSFIPPT
ECCCCCCCCCCCCCC		29.3122369663
264PhosphorylationFDNTPSSTSFIPPTN
CCCCCCCCCCCCCCC		31.8122369663
265PhosphorylationDNTPSSTSFIPPTNS
CCCCCCCCCCCCCCC		24.1122369663
270PhosphorylationSTSFIPPTNSVSEKL
CCCCCCCCCCHHHHH		34.4722369663
272PhosphorylationSFIPPTNSVSEKLSD
CCCCCCCCHHHHHHC		29.5121440633
274PhosphorylationIPPTNSVSEKLSDFK
CCCCCCHHHHHHCCC		28.9122369663
278PhosphorylationNSVSEKLSDFKIETS
CCHHHHHHCCCCCCC		52.6622369663
284PhosphorylationLSDFKIETSKEDLIN
HHCCCCCCCHHHHHH		48.8822369663
285PhosphorylationSDFKIETSKEDLINK
HCCCCCCCHHHHHHC		22.6622369663
293PhosphorylationKEDLINKTAPAKKES
HHHHHHCCCCCCCCC		33.1321440633
300PhosphorylationTAPAKKESPTTYGAA
CCCCCCCCCCCCCCC		36.1019779198
303PhosphorylationAKKESPTTYGAAYPY
CCCCCCCCCCCCCCC		24.2819779198
304PhosphorylationKKESPTTYGAAYPYG
CCCCCCCCCCCCCCC		13.7719779198
308PhosphorylationPTTYGAAYPYGGPLL
CCCCCCCCCCCCCCC		9.1019779198
310PhosphorylationTYGAAYPYGGPLLQP
CCCCCCCCCCCCCCC		23.2619779198
329PhosphorylationPGHPHNISSPIYGIR
CCCCCCCCCCCCCCC		35.0730377154
330PhosphorylationGHPHNISSPIYGIRS
CCCCCCCCCCCCCCC		16.1228889911
367PhosphorylationSHSLNANSPIPLTQS
CCCCCCCCCCCCCCC		23.0728889911
374PhosphorylationSPIPLTQSPIHLAPV
CCCCCCCCCCEEEEC		22.1628889911
481PhosphorylationHHGRNNNSMSSHNDN
CCCCCCCCCCCCCCC		23.3621440633
483PhosphorylationGRNNNSMSSHNDNDN
CCCCCCCCCCCCCCC		28.4128889911
543PhosphorylationSNATNSNSAEKQRKI
CCCCCCCHHHHHHHH		37.3121551504
583AcetylationHGCRFLQKQLDILGS
HHHHHHHHHHHHHCH		55.7824489116
590PhosphorylationKQLDILGSKAADAIF
HHHHHHCHHHHHHHH		18.7130377154
804AcetylationFGSNVIEKILKTAIV
CCHHHHHHHHHHHHC		42.0624489116
888PhosphorylationIGMLHLDS-------
EEEEECCC-------		48.7821440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUF4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUF4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUF4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
3HAO_YEASTBNA1physical
16554755
DBP2_YEASTDBP2physical
16554755
POP2_YEASTPOP2physical
17389596
CCR4_YEASTCCR4physical
17389596
DEF1_YEASTDEF1physical
18467557
WHI3_YEASTWHI3physical
18467557
PUB1_YEASTPUB1physical
18467557
CAF40_YEASTCAF40physical
18467557
HO_YEASTHOphysical
18327269
KRR1_YEASTKRR1genetic
19061648
PT309_YEASTPET309genetic
19061648
NOP56_YEASTNOP56genetic
19061648
LSM3_YEASTLSM3genetic
19061648
FBRL_YEASTNOP1genetic
19061648
POP8_YEASTPOP8genetic
19061648
LSM1_YEASTLSM1genetic
19061648
HIR2_YEASTHIR2genetic
19061648
DBP5_YEASTDBP5genetic
19061648
RPB1_YEASTRPO21genetic
19061648
NMD5_YEASTNMD5genetic
19061648
CAF20_YEASTCAF20physical
20705650
HO_YEASTHOphysical
21685478
SCC1_YEASTMCD1genetic
27708008
MED10_YEASTNUT2genetic
27708008
AAR2_YEASTAAR2genetic
27708008
CND2_YEASTBRN1genetic
27708008
ENP1_YEASTENP1genetic
27708008
SUB2_YEASTSUB2genetic
27708008
FAL1_YEASTFAL1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
UTP5_YEASTUTP5genetic
27708008
ACT_YEASTACT1genetic
27708008
IPI1_YEASTIPI1genetic
27708008
UTP9_YEASTUTP9genetic
27708008
NUP85_YEASTNUP85genetic
27708008
RRN3_YEASTRRN3genetic
27708008
UTP13_YEASTUTP13genetic
27708008
GSP1_YEASTGSP1genetic
27708008
UTP15_YEASTUTP15genetic
27708008
RRP5_YEASTRRP5genetic
27708008
NOG2_YEASTNOG2genetic
27708008
HRP1_YEASTHRP1genetic
27708008
PROF_YEASTPFY1genetic
27708008
PRP4_YEASTPRP4genetic
27708008
CSG2_YEASTCSG2genetic
27708008
NPL4_YEASTNPL4genetic
27708008
AIM4_YEASTAIM4genetic
27708008
GBP2_YEASTGBP2genetic
27708008
MGR1_YEASTMGR1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
RRP8_YEASTRRP8genetic
27708008
SAC3_YEASTSAC3genetic
27708008
UME6_YEASTUME6genetic
27708008
SEM1_YEASTSEM1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
UBP3_YEASTUBP3genetic
27708008
RTF1_YEASTRTF1genetic
27708008
RTG2_YEASTRTG2genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
SMI1_YEASTSMI1genetic
27708008
THP2_YEASTTHP2genetic
27708008
RL16A_YEASTRPL16Agenetic
27708008
LSM1_YEASTLSM1genetic
27708008
RPA34_YEASTRPA34genetic
27708008
YJ24_YEASTKCH1genetic
27708008
HIR3_YEASTHIR3genetic
27708008
IXR1_YEASTIXR1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
MUD2_YEASTMUD2genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
FKS1_YEASTFKS1genetic
27708008
MSC1_YEASTMSC1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
BRE5_YEASTBRE5genetic
27708008
TOP1_YEASTTOP1genetic
27708008
RRP6_YEASTRRP6genetic
27708008
HIR2_YEASTHIR2genetic
27708008
RAD1_YEASTRAD1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
MED1_YEASTMED1genetic
27708008
OPY2_YEASTOPY2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUF4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-210; THR-212;SER-330; SER-367 AND SER-374, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205 AND THR-212, ANDMASS SPECTROMETRY.

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