| UniProt ID | AAR2_YEAST | |
|---|---|---|
| UniProt AC | P32357 | |
| Protein Name | A1 cistron-splicing factor AAR2 | |
| Gene Name | AAR2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 355 | |
| Subcellular Localization | Cytoplasm. Nucleus. This protein lacks a nuclear localization signal, it may interact in the cytoplasm with a component of spliceosomes via the leucine-zipper and then be transported into the nucleus. | |
| Protein Description | Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth.. | |
| Protein Sequence | MNTVPFTSAPIEVTIGIDQYSFNVKENQPFHGIKDIPIGHVHVIHFQHADNSSMRYGYWFDCRMGNFYIQYDPKDGLYKMMEERDGAKFENIVHNFKERQMMVSYPKIDEDDTWYNLTEFVQMDKIRKIVRKDENQFSYVDSSMTTVQENELLKSSLQKAGSKMEAKNEDDPAHSLNYTVINFKSREAIRPGHEMEDFLDKSYYLNTVMLQGIFKNSSNYFGELQFAFLNAMFFGNYGSSLQWHAMIELICSSATVPKHMLDKLDEILYYQIKTLPEQYSDILLNERVWNICLYSSFQKNSLHNTEKIMENKYPELLGKDNEDDALIYGISDEERDDEDDEHNPTIVGGLYYQRP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 253 | Phosphorylation | MIELICSSATVPKHM HHHHHHCCCCCCHHH | 24.45 | 21764848 | |
| 274 | Phosphorylation | ILYYQIKTLPEQYSD HHHHHHHCCHHHHHH | 49.53 | 21764848 | |
| 301 | Phosphorylation | YSSFQKNSLHNTEKI HHHHHCCCCCCHHHH | 37.73 | 27017623 | |
| 328 | Phosphorylation | NEDDALIYGISDEER CCCCCEEEECCHHHC | 14.84 | 21764848 | |
| 331 | Phosphorylation | DALIYGISDEERDDE CCEEEECCHHHCCCC | 34.31 | 21764848 | |
| 345 | Phosphorylation | EDDEHNPTIVGGLYY CCCCCCCEEEEEEEE | 33.34 | 20377248 | |
| 351 | Phosphorylation | PTIVGGLYYQRP--- CEEEEEEEECCC--- | 10.79 | 19823750 | |
| 352 | Phosphorylation | TIVGGLYYQRP---- EEEEEEEECCC---- | 11.77 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AAR2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AAR2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AAR2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY. | |
