NRT1_YEAST - dbPTM
NRT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NRT1_YEAST
UniProt AC Q08485
Protein Name Nicotinamide riboside transporter 1
Gene Name NRT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 598
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description High-affinity pH-dependent nicotinamide riboside transporter which also transports thiamine with low affinity. Involved in 5-fluorocytosine sensitivity..
Protein Sequence MSFSSIVSKFLRYLEIPAKNRTAVNFLRNPDLQPIKSANQTWGFWSNLAYWGAVSFTAGTWMSGSAALSVGLSYPETIVSFLLGNVLTIIFTMANSYPGYDWKIGFTLAQRFVFGIYGSAFGIIIRILMSIVNYGSNAWLGGLSINMILDSWSHHYLHLPNTLSPSVAMTTKQLVGFIIFHVLTALCYFMKPYHMNYLLIWSCVATCFAMLGIVIYLTKNAHGVGELFTSTKSTVTGSKRAWAWVYMISYWFGSISPGSTNQSDYSRFGSSNLAIWTGSVCALLIPATLVPIFGVISASTCDKLYGKQFWMPMDIFDYWLTNNYSAGARAGAFFCGLCFTMSQMSSTISNCGFATGMDMAGLLPKYVDIKRGALFCACISWACLPWNFYNSSSTFLTVMSSFGVVMTPIIAVMICDNFLIRKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMAPGLPGIAWEVNNNYFHDSGIVKFFYGDSFFSFLISFFVYWGLCVFFPFKITVRHDDKDYYGAFTDEEARKKGMIPYSEISEEEIRAYTLGECYTTGHEYKPESSDNESPELIKTSSENTNVFEIVHQKDDEKHSFSTTQQVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
559PhosphorylationGHEYKPESSDNESPE
CCCCCCCCCCCCCCC		52.0620377248
560PhosphorylationHEYKPESSDNESPEL
CCCCCCCCCCCCCCH		42.6721440633
570PhosphorylationESPELIKTSSENTNV
CCCCHHCCCCCCCCE		30.4128889911
571PhosphorylationSPELIKTSSENTNVF
CCCHHCCCCCCCCEE		30.5625521595
572PhosphorylationPELIKTSSENTNVFE
CCHHCCCCCCCCEEE		39.8528889911
575PhosphorylationIKTSSENTNVFEIVH
HCCCCCCCCEEEEEE		28.8028889911
588UbiquitinationVHQKDDEKHSFSTTQ
EEECCCCCCCCCCCC		52.0923749301
590PhosphorylationQKDDEKHSFSTTQQV
ECCCCCCCCCCCCCC		31.7720377248
592PhosphorylationDDEKHSFSTTQQVV-
CCCCCCCCCCCCCC-		33.2922369663
593PhosphorylationDEKHSFSTTQQVV--
CCCCCCCCCCCCC--		26.9820377248
594PhosphorylationEKHSFSTTQQVV---
CCCCCCCCCCCC---		18.7922369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NRT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NRT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NRT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
THI7_YEASTTHI7genetic
18201975
TMN1_YEASTEMP70physical
16093310
GLRX5_YEASTGRX5genetic
21623372
POS5_YEASTPOS5genetic
21623372
SYSM_YEASTDIA4genetic
21623372
QCR10_YEASTQCR10genetic
21623372
QCR7_YEASTQCR7genetic
21623372
SGPL_YEASTDPL1genetic
21623372
FABG_YEASTOAR1genetic
21623372
ERG2_YEASTERG2genetic
21623372
ELO2_YEASTELO2genetic
21623372
GLRX1_YEASTGRX1genetic
21623372
XPT1_YEASTXPT1genetic
21623372
SMD1_YEASTSMD1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
RPB1_YEASTRPO21genetic
27708008
TAF12_YEASTTAF12genetic
27708008
TFB1_YEASTTFB1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
BRL1_YEASTBRL1genetic
27708008
SN114_YEASTSNU114genetic
27708008
MED14_YEASTRGR1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
GPI12_YEASTGPI12genetic
27708008
LCB1_YEASTLCB1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NRT1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-570, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory