GLRX1_YEAST - dbPTM
GLRX1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLRX1_YEAST
UniProt AC P25373
Protein Name Glutaredoxin-1
Gene Name GRX1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 110
Subcellular Localization Cytoplasm.
Protein Description Component of the glutathione system which performs several activities such as glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. GRX1 is less active as an oxidoreductase than GRX2..
Protein Sequence MVSQETIKHVKDLIAENEIFVASKTYCPYCHAALNTLFEKLKVPRSKVLVLQLNDMKEGADIQAALYEINGQRTVPNIYINGKHIGGNDDLQELRETGELEELLEPILAN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MVSQETIKHV
-----CCCHHHHHHH		22.4730377154
8UbiquitinationMVSQETIKHVKDLIA
CCCHHHHHHHHHHHH		50.1722817900
82-HydroxyisobutyrylationMVSQETIKHVKDLIA
CCCHHHHHHHHHHHH		50.17-
11UbiquitinationQETIKHVKDLIAENE
HHHHHHHHHHHHHCC		46.6822817900
11AcetylationQETIKHVKDLIAENE
HHHHHHHHHHHHHCC		46.6822865919
112-HydroxyisobutyrylationQETIKHVKDLIAENE
HHHHHHHHHHHHHCC		46.68-
27GlutathionylationFVASKTYCPYCHAAL
EEEECCCHHHHHHHH		2.0417327665
40AcetylationALNTLFEKLKVPRSK
HHHHHHHHCCCCHHH		46.3924489116
422-HydroxyisobutyrylationNTLFEKLKVPRSKVL
HHHHHHCCCCHHHEE		62.35-
83AcetylationPNIYINGKHIGGNDD
CEEEECCEEECCCCC		27.7924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLRX1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLRX1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLRX1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GLRX2_YEASTGRX2genetic
10844700
URE2_YEASTURE2genetic
19321443
PRX1_YEASTPRX1genetic
20059400
GLRX2_YEASTGRX2genetic
20522499
GLRX7_YEASTGRX7genetic
20522499
GLRX6_YEASTGRX6genetic
20522499
JEN1_YEASTJEN1genetic
21623372
ATP14_YEASTATP14genetic
21623372
GLRX2_YEASTGRX2genetic
25392302
MRM2_YEASTMRM2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RV167_YEASTRVS167genetic
27708008
UBP3_YEASTUBP3genetic
27708008
RAD4_YEASTRAD4genetic
27708008
VAM7_YEASTVAM7genetic
27708008
PDR11_YEASTPDR11genetic
27708008
FEN1_YEASTRAD27genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ENV10_YEASTENV10genetic
27708008
KIN4_YEASTKIN4genetic
27708008
PUS7_YEASTPUS7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLRX1_YEAST

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Related Literatures of Post-Translational Modification

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