THI7_YEAST - dbPTM
THI7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THI7_YEAST
UniProt AC Q05998
Protein Name Thiamine transporter
Gene Name THI7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 598
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Responsible for intake of thiamine..
Protein Sequence MSFGSKVSRALRFLEIPVKDRASVSFLKNPDLQPIKSANQTWGFWSNFAYWGVMSFSVGTWMSASSALGVGLSYPETIGTFIVGDVLTIIFTLANSCPGYDWKVGFTLAQRFVFGIYGSAFGIIIRILMSIVNYGSNAWVGGLCINMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIFHVLTAFCYLMKPYHMNYILIWSCVATFFSMLGMVIYLAKQAHGVGELFTSTKSTATGSTKAWAWVYMISYWFGSVSPGSTNQSDYSRFGSSNWAIWAGTICALLIPTTLIPVFGVIGASTCDKLYGEQYWMPMDIFNHWLTTNYSAGARAGAFFCGLSFVLSQMSYTISNCGFASGMDLAGLLPKYVDIKRGALFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIISVMICDNFLIRKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMTPGLPGIAWEVNNDYFHNTGIVNFFYGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEIRAYTLGEGYTTGHEYRPEGSDDEIPELVKTSSENTNEFEIVHHKNNEKQSSTASEKAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationIPVKDRASVSFLKNP
CCCCCCCCEEECCCC		21.1328889911
236PhosphorylationTSTKSTATGSTKAWA
CCCCCCCCCCCHHHH		31.5828889911
239PhosphorylationKSTATGSTKAWAWVY
CCCCCCCCHHHHHHH		26.5728889911
533PhosphorylationKKGMVPYSEISEEEI
HCCCCCHHHCCHHHH		23.5328889911
549PhosphorylationAYTLGEGYTTGHEYR
HHCCCCCCCCCCCCC		9.2319779198
555PhosphorylationGYTTGHEYRPEGSDD
CCCCCCCCCCCCCCC		26.2921440633
560PhosphorylationHEYRPEGSDDEIPEL
CCCCCCCCCCCCCHH		39.9820377248
570PhosphorylationEIPELVKTSSENTNE
CCCHHHHCCCCCCCC		29.9725521595
571PhosphorylationIPELVKTSSENTNEF
CCHHHHCCCCCCCCE		29.9125521595
572PhosphorylationPELVKTSSENTNEFE
CHHHHCCCCCCCCEE		39.8525521595
575PhosphorylationVKTSSENTNEFEIVH
HHCCCCCCCCEEEEE		31.8825521595
588UbiquitinationVHHKNNEKQSSTASE
EEECCCCCCCCCHHH		58.5723749301
590PhosphorylationHKNNEKQSSTASEKA
ECCCCCCCCCHHHHC		40.5019795423
591PhosphorylationKNNEKQSSTASEKAA
CCCCCCCCCHHHHCC		26.0419684113
592PhosphorylationNNEKQSSTASEKAA-
CCCCCCCCHHHHCC-		39.1819684113
594PhosphorylationEKQSSTASEKAA---
CCCCCCHHHHCC---		39.4519684113
596UbiquitinationQSSTASEKAA-----
CCCCHHHHCC-----		47.3123749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THI7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THI7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THI7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDX3_YEASTPDX3genetic
21623372
THI3_YEASTTHI3genetic
21623372
QCR7_YEASTQCR7genetic
21623372
6PGD1_YEASTGND1genetic
21623372
COQ3_YEASTCOQ3genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
QCR8_YEASTQCR8genetic
21623372
MAL32_YEASTMAL32genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
SCS7_YEASTSCS7genetic
21623372
COX7_YEASTCOX7genetic
21623372
SUR1_YEASTSUR1genetic
21623372
THI72_YEASTTHI72genetic
24778186
NRT1_YEASTNRT1genetic
24778186
RAD4_YEASTRAD4genetic
27708008
RAV1_YEASTRAV1genetic
27708008
SNU23_YEASTSNU23genetic
27708008
NSE4_YEASTNSE4genetic
27708008
CDC48_YEASTCDC48genetic
27708008
GLE1_YEASTGLE1genetic
27708008
UBC3_YEASTCDC34genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC4_YEASTCDC4genetic
27708008
NSE1_YEASTNSE1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
TPT1_YEASTTPT1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
ULP1_YEASTULP1genetic
27708008
SRP54_YEASTSRP54genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SWD1_YEASTSWD1genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
AVT5_YEASTAVT5genetic
27708008
ECM8_YEASTECM8genetic
27708008
THI2_YEASTTHI2genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
THI3_YEASTTHI3genetic
27708008
TPS2_YEASTTPS2genetic
27708008
RV167_YEASTRVS167genetic
27708008
XRN1_YEASTXRN1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
ICE2_YEASTICE2genetic
27708008
BNA3_YEASTBNA3genetic
27708008
ILM1_YEASTILM1genetic
27708008
YKF0_YEASTYKL050Cgenetic
27708008
RT109_YEASTRTT109genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
RAS2_YEASTRAS2genetic
27708008
FUMH_YEASTFUM1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THI7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-560 AND SER-572,AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560, AND MASSSPECTROMETRY.

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