| UniProt ID | RAV1_YEAST | |
|---|---|---|
| UniProt AC | P47104 | |
| Protein Name | Regulator of V-ATPase in vacuolar membrane protein 1 | |
| Gene Name | RAV1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1357 | |
| Subcellular Localization | Endomembrane system . Probably membrane-associated, associates with high density membrane compartment like early endosomes. | |
| Protein Description | Component of the RAVE complex, which is required for stable assembly of the vacuolar ATPase complex V-ATPase under many conditions. Required for transport between the early endosome and the late endosome/prevacuolar compartment (PVC), suggesting that assembly of vacuolar ATPase at the early endosome is required for transport from the early endosome to the PVC.. | |
| Protein Sequence | MSLNFLPGRPNATPQTACQATWQNHTIFAYCSGNNLIILTNKFTRLQTIYTQSDCTAVDINSQNGFIALSFHNRVLIYKPIHQIMQNPKWTQCCQLFHDDTPVNCLRWSSDNELAIGSDFLSFWKIKDNFGVYQPILQWNQKQPKPVYNVIISQDSQLIVSIGKYDCNAKLWKRVSIVGEQAIFNLTMLPHPKPITAMRWKKEPDQVSKNNTASHALYTLCEDKVLRIWSCFEMEKNHTVQIWGEVPLSPTQKFCVIIDNWIIRQTLSVKDSEIFDISDSDIVILGSMTGEMEVLALNNLSQDPPKPMTKKTISHKKVKKATMLNDTRYLYLPEIQPYDNVKGKLSFLVHDLQGVIRHLLIDILQLINNKTEDLSAALEHKFTGHNKSVQKLVRSSDGEALLTTSRFSENGVWYPQKLNHGVSLRLQNTIQTESPIKFAVVHELGKQVICLLENGALQAWECPTNRKEDSEQKQSYLRVETRLKEEKKIHPIVMLNTPEPKHSHERHFTALIFSDGSIKAFEVSLTRGIFEVKSDSLDIDGDDIYKISIIDPVHQTFVSNRPLISLITKKGLTRTYKAIVNYNDRHVQWIKACEINTGIMNCTCIRGSSTGKLCIVNSTGKVMSLWDLNRGVLEYEETFHNPIEDIDWTSTEYGQSIVSIGFTGYALLYTQLRYDYTNNTPSYLPIEKIDITAHTAHNIGDSVWMKNGTFVVASGNQFYIKDKSLDLTDPFTYQSIGSRKILSNDILHLSSVLNGPLPVYHPQFLIQAIYANKLQLVKELLLRLFLALRKLDFESQDVSNLDSNLGMDPLKYFIAKDRDYPVESFPDPYPCFNKTVSLALTEQLTKTTLPYLTRHQQITLITVIEAVDEVTKNENIVDYNGVRFLLGVKLFLSHKNIQKSILMRDVSWALHSDNKEILLSSIDRHITSWNRAREYRIAYWIKEQDLVKKFEDIAKYEFSKDDKRDPSRCAIFYLALKKKQILLSLWKMAIGHPEQQKMVRFISNDFTVPRWRTAALKNAFVLLSKHRYMDAAVFFLLTDSLKDCVNVLCKQVHDMDLAIGVCRVYEGDNGPVLGELLTAQMLPETIKENDRWKASFIYWKLRKQEVAIKALLTAPIDLENNSSIVDKEVCVNRSFLVEDPALLYLYNHLRNRNLKYFIGSLNVEAKIECTLILRVTDILCRMGCNYLAVSLVKNWKFIERNSIPVQKLLKSPTKDRAYSAIGAMASEPISTARMRPSLFDKFGSPSASDIESPNPKLPNSLLDDFLQPPPNSTSSNSLAQSSSSAPRSILDEFVSPSYSQHKENLTPKAPNDSVGETDNSENRKDKLSKDILDDLSSQKPQKPKKSAITKNLLDDFV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 118 | Phosphorylation | DNELAIGSDFLSFWK CCCEEECCCHHHEEE | 21.05 | 27017623 | |
| 122 | Phosphorylation | AIGSDFLSFWKIKDN EECCCHHHEEEEHHC | 29.11 | 27017623 | |
| 381 | Acetylation | LSAALEHKFTGHNKS HHHHHHHHHCCCCHH | 34.93 | 24489116 | |
| 437 | Acetylation | IQTESPIKFAVVHEL CCCCCCEEEEEEHHC | 30.56 | 24489116 | |
| 597 | Phosphorylation | IKACEINTGIMNCTC EEEEEECCCCCCCEE | 33.47 | 27017623 | |
| 935 | Phosphorylation | SWNRAREYRIAYWIK CHHHHHHHHHEEEEH | 11.19 | 28889911 | |
| 1211 | Phosphorylation | PVQKLLKSPTKDRAY CHHHHCCCCCCCHHH | 37.46 | 19823750 | |
| 1213 | Phosphorylation | QKLLKSPTKDRAYSA HHHCCCCCCCHHHHH | 53.30 | 19823750 | |
| 1219 | Phosphorylation | PTKDRAYSAIGAMAS CCCCHHHHHHHHHCC | 16.66 | 25752575 | |
| 1230 | Phosphorylation | AMASEPISTARMRPS HHCCCCCCCCCCCHH | 27.08 | 27017623 | |
| 1231 | Phosphorylation | MASEPISTARMRPSL HCCCCCCCCCCCHHH | 20.99 | 27017623 | |
| 1244 | Phosphorylation | SLFDKFGSPSASDIE HHHHHCCCCCHHHCC | 20.86 | 22369663 | |
| 1246 | Phosphorylation | FDKFGSPSASDIESP HHHCCCCCHHHCCCC | 41.94 | 22369663 | |
| 1248 | Phosphorylation | KFGSPSASDIESPNP HCCCCCHHHCCCCCC | 43.38 | 22369663 | |
| 1252 | Phosphorylation | PSASDIESPNPKLPN CCHHHCCCCCCCCCC | 30.25 | 24961812 | |
| 1288 | Phosphorylation | SSSSAPRSILDEFVS CCCCCCHHHHHHHHC | 26.83 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAV1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAV1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAV1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1219; SER-1244 ANDSER-1248, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1244, AND MASSSPECTROMETRY. | |
