| UniProt ID | SC160_YEAST | |
|---|---|---|
| UniProt AC | P06105 | |
| Protein Name | Protein SCP160 | |
| Gene Name | SCP160 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1222 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side. Nucleus membrane Peripheral membrane protein Cytoplasmic side. Attached to the cytoplasmic surface of the ER-nuclear envelope membranes. |
|
| Protein Description | Involved in the control of mitotic chromosome transmission. Required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromosomes.. | |
| Protein Sequence | MSEEQTAIDSPPSTVEGSVETVTTIDSPSTTASTIAATAEEHPQLEKKPTPLPSLKDLPSLGSNAAFANVKVSWGPNMKPAVSNSPSPSPSAPSLTTGLGAKRMRSKNIQEAFTLDLQSQLSITKPELSRIVQSVKKNHDVSVESTLSKNARTFLVSGVAANVHEAKRELVKKLTKPINAVIEVPSKCKASIIGSGGRTIREISDAYEVKINVSKEVNENSYDEDMDDTTSNVSLFGDFESVNLAKAKILAIVKEETKNATIKLVVEDEKYLPYIDVSEFASDEGDEEVKVQFYKKSGDIVILGPREKAKATKTSIQDYLKKLASNLDEEKVKIPSKFQFLIDAEELKEKYNVIVTFPSTPDDELVSFVGLRDKVGEAITYARSSSKSYVVESLDISKAHSKNLTHAKNLIMYFTKYSVLKGLEESHPNVKISLPSIQSLPTAETVTIHISAKSDEANDIKAVRKELISFVNNIPPSETLVITDLDYELFGGSIKHCLLASESSVAFVQFGDYYPNDNSILLVALTEDEDFKPSIEEIQASLNKANESLNSLRTKQNNMETKTYEFSEEVQDSLFKPSSATWKLIMEDISEQEGHLQIKLHTPEENQLTVRGDEKAAKAANKIFESILNSPSSKSKMTVNIPANSVARLIGNKGSNLQQIREKFACQIDIPNEENNNASKDKTVEVTLTGLEYNLTHAKKYLAAEAKKWADIITKELIVPVKFHGSLIGPHGTYRNRLQEKYNVFINFPRDNEIVTIRGPSRGVNKAHEELKALLDFEMENGHKMVINVPAEHVPRIIGKNGDNINDIRAEYGVEMDFLQKSTDPKAQETGEVELEITGSRQNIKDAAKRVESIVAEASDFVTEVLKIDHKYHKSIVGSGGHILREIISKAGGEEIRNKSVDIPNADSENKDITVQGPQKFVKKVVEEINKIVKDAENSVTKTIDIPAERKGALIGPGGIVRRQLESEFNINLFVPNKDDPSGKITITGAPENVEKAEKKILNEIIRENFDREVDVPASIYEYVSERGAFIQKLRMDLSVNVRFGNTSKKANKLARAPIEIPLEKVCGSTEGENAEKTKFTIEEVGAPTSSEEGDITMRLTYEPIDLSSILSDGEEKEVTKDTSNDSAKKEEALDTAVKLIKERIAKAPSATYAGYVWGADTRRFNMIVGPGGSNIKKIREAADVIINVPRKSDKVNDVVYIRGTKAGVEKAGEMVLKSLRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSEEQTAID ------CCHHHCCCC | 62.23 | 30377154 | |
| 10 | Phosphorylation | EEQTAIDSPPSTVEG HHHCCCCCCCCCCCC | 32.37 | 30377154 | |
| 14 | Phosphorylation | AIDSPPSTVEGSVET CCCCCCCCCCCCEEE | 28.49 | 30377154 | |
| 18 | Phosphorylation | PPSTVEGSVETVTTI CCCCCCCCEEEEEEE | 11.86 | 30377154 | |
| 21 | Phosphorylation | TVEGSVETVTTIDSP CCCCCEEEEEEECCC | 22.46 | 30377154 | |
| 23 | Phosphorylation | EGSVETVTTIDSPST CCCEEEEEEECCCCC | 26.00 | 30377154 | |
| 24 | Phosphorylation | GSVETVTTIDSPSTT CCEEEEEEECCCCCC | 20.60 | 30377154 | |
| 27 | Phosphorylation | ETVTTIDSPSTTAST EEEEEECCCCCCHHH | 19.52 | 30377154 | |
| 34 | Phosphorylation | SPSTTASTIAATAEE CCCCCHHHHHHHHHH | 16.51 | 30377154 | |
| 50 | Phosphorylation | PQLEKKPTPLPSLKD CHHCCCCCCCCCHHC | 46.46 | 22369663 | |
| 54 | Phosphorylation | KKPTPLPSLKDLPSL CCCCCCCCHHCCCCC | 56.59 | 22369663 | |
| 56 | Acetylation | PTPLPSLKDLPSLGS CCCCCCHHCCCCCCC | 62.65 | 24489116 | |
| 60 | Phosphorylation | PSLKDLPSLGSNAAF CCHHCCCCCCCCCCC | 53.30 | 22369663 | |
| 63 | Phosphorylation | KDLPSLGSNAAFANV HCCCCCCCCCCCEEE | 28.70 | 22369663 | |
| 73 | Phosphorylation | AFANVKVSWGPNMKP CCEEEEEEECCCCCC | 22.16 | 22369663 | |
| 79 | Acetylation | VSWGPNMKPAVSNSP EEECCCCCCCCCCCC | 36.14 | 24489116 | |
| 83 | Phosphorylation | PNMKPAVSNSPSPSP CCCCCCCCCCCCCCC | 33.42 | 22369663 | |
| 85 | Phosphorylation | MKPAVSNSPSPSPSA CCCCCCCCCCCCCCC | 21.17 | 22369663 | |
| 87 | Phosphorylation | PAVSNSPSPSPSAPS CCCCCCCCCCCCCCC | 37.52 | 22369663 | |
| 89 | Phosphorylation | VSNSPSPSPSAPSLT CCCCCCCCCCCCCCC | 35.51 | 22369663 | |
| 91 | Phosphorylation | NSPSPSPSAPSLTTG CCCCCCCCCCCCCCC | 58.09 | 22369663 | |
| 94 | Phosphorylation | SPSPSAPSLTTGLGA CCCCCCCCCCCCCCH | 37.76 | 22369663 | |
| 96 | Phosphorylation | SPSAPSLTTGLGAKR CCCCCCCCCCCCHHH | 24.13 | 22369663 | |
| 97 | Phosphorylation | PSAPSLTTGLGAKRM CCCCCCCCCCCHHHH | 35.38 | 22369663 | |
| 134 | Phosphorylation | ELSRIVQSVKKNHDV HHHHHHHHHHHCCCC | 25.63 | 23749301 | |
| 136 | Succinylation | SRIVQSVKKNHDVSV HHHHHHHHHCCCCCH | 53.78 | 23954790 | |
| 142 | Phosphorylation | VKKNHDVSVESTLSK HHHCCCCCHHHHCCC | 26.65 | 19779198 | |
| 145 | Phosphorylation | NHDVSVESTLSKNAR CCCCCHHHHCCCCCH | 32.28 | 30377154 | |
| 146 | Phosphorylation | HDVSVESTLSKNART CCCCHHHHCCCCCHH | 22.88 | 27738172 | |
| 149 | Acetylation | SVESTLSKNARTFLV CHHHHCCCCCHHHHH | 58.71 | 24489116 | |
| 157 | Phosphorylation | NARTFLVSGVAANVH CCHHHHHHHHHCCHH | 29.69 | 30377154 | |
| 173 | Acetylation | AKRELVKKLTKPINA HHHHHHHHHCCCCCE | 54.64 | 24489116 | |
| 175 | Phosphorylation | RELVKKLTKPINAVI HHHHHHHCCCCCEEE | 43.59 | 29136822 | |
| 176 | Acetylation | ELVKKLTKPINAVIE HHHHHHCCCCCEEEE | 55.10 | 24489116 | |
| 195 | Phosphorylation | CKASIIGSGGRTIRE CCEEEECCCCCCCEE | 27.89 | 27214570 | |
| 204 | Phosphorylation | GRTIREISDAYEVKI CCCCEEECCEEEEEE | 16.07 | 30377154 | |
| 221 | Phosphorylation | SKEVNENSYDEDMDD CCCCCCCCCCCCCCC | 27.99 | 28889911 | |
| 241 | Phosphorylation | SLFGDFESVNLAKAK EEECCHHHCCHHHCC | 19.12 | 28889911 | |
| 254 | Acetylation | AKILAIVKEETKNAT CCEEEEECHHHCCCE | 43.66 | 24489116 | |
| 282 | Phosphorylation | IDVSEFASDEGDEEV EEHHHHCCCCCCCEE | 41.33 | 21440633 | |
| 297 | Phosphorylation | KVQFYKKSGDIVILG EEEEEEECCCEEEEC | 37.23 | 21440633 | |
| 321 | Acetylation | TSIQDYLKKLASNLD HHHHHHHHHHHCCCC | 39.24 | 24489116 | |
| 321 | Succinylation | TSIQDYLKKLASNLD HHHHHHHHHHHCCCC | 39.24 | 23954790 | |
| 322 | Acetylation | SIQDYLKKLASNLDE HHHHHHHHHHCCCCH | 46.84 | 22865919 | |
| 325 | Phosphorylation | DYLKKLASNLDEEKV HHHHHHHCCCCHHHC | 48.65 | 28889911 | |
| 337 | Acetylation | EKVKIPSKFQFLIDA HHCCCCCCCEEEECH | 37.52 | 24489116 | |
| 348 | Acetylation | LIDAEELKEKYNVIV EECHHHHHHHCCEEE | 56.28 | 24489116 | |
| 356 | Phosphorylation | EKYNVIVTFPSTPDD HHCCEEEECCCCCCH | 20.78 | 24961812 | |
| 359 | Phosphorylation | NVIVTFPSTPDDELV CEEEECCCCCCHHHH | 48.67 | 24961812 | |
| 360 | Phosphorylation | VIVTFPSTPDDELVS EEEECCCCCCHHHHH | 30.86 | 21440633 | |
| 367 | Phosphorylation | TPDDELVSFVGLRDK CCCHHHHHHEEECCC | 27.17 | 30377154 | |
| 380 | Phosphorylation | DKVGEAITYARSSSK CCHHHHHHHHCCCCC | 20.41 | 22369663 | |
| 381 | Phosphorylation | KVGEAITYARSSSKS CHHHHHHHHCCCCCE | 8.23 | 22369663 | |
| 387 | Acetylation | TYARSSSKSYVVESL HHHCCCCCEEEEEEC | 47.99 | 24489116 | |
| 398 | Acetylation | VESLDISKAHSKNLT EEECCHHHHHHCCCH | 50.91 | 24489116 | |
| 413 | Phosphorylation | HAKNLIMYFTKYSVL HHHHHHHHHHHHHHH | 10.91 | 22369663 | |
| 415 | Phosphorylation | KNLIMYFTKYSVLKG HHHHHHHHHHHHHHC | 16.16 | 22369663 | |
| 421 | Acetylation | FTKYSVLKGLEESHP HHHHHHHHCHHHHCC | 60.33 | 24489116 | |
| 461 | Acetylation | SDEANDIKAVRKELI CCCCHHHHHHHHHHH | 43.63 | 24489116 | |
| 576 | Acetylation | EVQDSLFKPSSATWK HHHHHHCCCCCHHHE | 49.65 | 24489116 | |
| 615 | Acetylation | LTVRGDEKAAKAANK CEECCCHHHHHHHHH | 59.38 | 24489116 | |
| 622 | Acetylation | KAAKAANKIFESILN HHHHHHHHHHHHHHC | 44.01 | 24489116 | |
| 626 | Phosphorylation | AANKIFESILNSPSS HHHHHHHHHHCCCCC | 22.94 | 28889911 | |
| 630 | Phosphorylation | IFESILNSPSSKSKM HHHHHHCCCCCCCCC | 23.78 | 22369663 | |
| 632 | Phosphorylation | ESILNSPSSKSKMTV HHHHCCCCCCCCCEE | 50.66 | 19779198 | |
| 633 | Phosphorylation | SILNSPSSKSKMTVN HHHCCCCCCCCCEEE | 44.31 | 22369663 | |
| 638 | Phosphorylation | PSSKSKMTVNIPANS CCCCCCCEEECCHHH | 17.71 | 22369663 | |
| 645 | Phosphorylation | TVNIPANSVARLIGN EEECCHHHHHHHHCC | 21.18 | 22369663 | |
| 655 | Phosphorylation | RLIGNKGSNLQQIRE HHHCCCCCCHHHHHH | 35.66 | 30377154 | |
| 663 | Acetylation | NLQQIREKFACQIDI CHHHHHHHHCCCCCC | 28.54 | 25381059 | |
| 699 | Acetylation | EYNLTHAKKYLAAEA EEEHHHHHHHHHHHH | 34.05 | 24489116 | |
| 707 | 2-Hydroxyisobutyrylation | KYLAAEAKKWADIIT HHHHHHHHHHHHHHH | 40.11 | - | |
| 715 | Acetylation | KWADIITKELIVPVK HHHHHHHHHHEEEEE | 39.86 | 24489116 | |
| 715 | Ubiquitination | KWADIITKELIVPVK HHHHHHHHHHEEEEE | 39.86 | 17644757 | |
| 722 | Acetylation | KELIVPVKFHGSLIG HHHEEEEEECCCCCC | 26.10 | 24489116 | |
| 722 | Ubiquitination | KELIVPVKFHGSLIG HHHEEEEEECCCCCC | 26.10 | 17644757 | |
| 741 | Acetylation | YRNRLQEKYNVFINF HHHHHHHHCCEEEEC | 29.21 | 24489116 | |
| 756 | Phosphorylation | PRDNEIVTIRGPSRG CCCCCCEEEECCCCC | 15.60 | 19779198 | |
| 761 | Phosphorylation | IVTIRGPSRGVNKAH CEEEECCCCCCHHHH | 44.48 | 19779198 | |
| 800 | Acetylation | HVPRIIGKNGDNIND HCCEEECCCCCCHHH | 47.55 | 24489116 | |
| 821 | Acetylation | VEMDFLQKSTDPKAQ CCCEEECCCCCCCCC | 58.43 | 24489116 | |
| 826 | Acetylation | LQKSTDPKAQETGEV ECCCCCCCCCCCCCE | 66.56 | 24489116 | |
| 853 | Phosphorylation | DAAKRVESIVAEASD HHHHHHHHHHHHHHH | 21.36 | 19779198 | |
| 859 | Phosphorylation | ESIVAEASDFVTEVL HHHHHHHHHHHHHHH | 24.08 | 19779198 | |
| 875 | Phosphorylation | IDHKYHKSIVGSGGH CCCCCHHHHCCCCHH | 14.81 | 21440633 | |
| 890 | Acetylation | ILREIISKAGGEEIR HHHHHHHHCCCHHHH | 40.41 | 24489116 | |
| 900 | Phosphorylation | GEEIRNKSVDIPNAD CHHHHHCCCCCCCCC | 28.68 | 27214570 | |
| 911 | Acetylation | PNADSENKDITVQGP CCCCCCCCCCEECCC | 46.59 | 24489116 | |
| 911 | Ubiquitination | PNADSENKDITVQGP CCCCCCCCCCEECCC | 46.59 | 23749301 | |
| 920 | Acetylation | ITVQGPQKFVKKVVE CEECCCHHHHHHHHH | 56.08 | 24489116 | |
| 920 | Ubiquitination | ITVQGPQKFVKKVVE CEECCCHHHHHHHHH | 56.08 | 24961812 | |
| 931 | Acetylation | KVVEEINKIVKDAEN HHHHHHHHHHHHHHH | 55.31 | 24489116 | |
| 934 | Succinylation | EEINKIVKDAENSVT HHHHHHHHHHHHCCE | 55.48 | 23954790 | |
| 934 | Ubiquitination | EEINKIVKDAENSVT HHHHHHHHHHHHCCE | 55.48 | 23749301 | |
| 942 | Acetylation | DAENSVTKTIDIPAE HHHHCCEEEEECCHH | 41.13 | 24489116 | |
| 978 | Acetylation | INLFVPNKDDPSGKI EEEECCCCCCCCCCE | 58.39 | 24489116 | |
| 984 | Ubiquitination | NKDDPSGKITITGAP CCCCCCCCEEEECCC | 40.80 | 15699485 | |
| 996 | Acetylation | GAPENVEKAEKKILN CCCHHHHHHHHHHHH | 58.52 | 24489116 | |
| 996 | Ubiquitination | GAPENVEKAEKKILN CCCHHHHHHHHHHHH | 58.52 | 23749301 | |
| 999 | Acetylation | ENVEKAEKKILNEII HHHHHHHHHHHHHHH | 50.39 | 24489116 | |
| 1019 | Phosphorylation | REVDVPASIYEYVSE CCCCCCHHHHHHHHH | 21.45 | 28889911 | |
| 1033 | 2-Hydroxyisobutyrylation | ERGAFIQKLRMDLSV HCCHHHHHHCCCEEE | 32.99 | - | |
| 1033 | Acetylation | ERGAFIQKLRMDLSV HCCHHHHHHCCCEEE | 32.99 | 24489116 | |
| 1065 | Acetylation | PIEIPLEKVCGSTEG CCCCCHHHHCCCCCC | 50.97 | 24489116 | |
| 1065 | Ubiquitination | PIEIPLEKVCGSTEG CCCCCHHHHCCCCCC | 50.97 | 23749301 | |
| 1069 | Phosphorylation | PLEKVCGSTEGENAE CHHHHCCCCCCCCCC | 20.40 | 23749301 | |
| 1070 | Phosphorylation | LEKVCGSTEGENAEK HHHHCCCCCCCCCCC | 33.04 | 27717283 | |
| 1077 | Ubiquitination | TEGENAEKTKFTIEE CCCCCCCCCCEEEEE | 55.38 | 23749301 | |
| 1079 | Acetylation | GENAEKTKFTIEEVG CCCCCCCCEEEEECC | 52.13 | 24489116 | |
| 1101 | Phosphorylation | GDITMRLTYEPIDLS CCEEEEEEEECCCHH | 18.57 | 29136822 | |
| 1102 | Phosphorylation | DITMRLTYEPIDLSS CEEEEEEEECCCHHH | 25.05 | 29136822 | |
| 1108 | Phosphorylation | TYEPIDLSSILSDGE EEECCCHHHHCCCCC | 16.16 | 22890988 | |
| 1109 | Phosphorylation | YEPIDLSSILSDGEE EECCCHHHHCCCCCC | 34.54 | 21082442 | |
| 1112 | Phosphorylation | IDLSSILSDGEEKEV CCHHHHCCCCCCEEC | 41.73 | 22369663 | |
| 1117 | Acetylation | ILSDGEEKEVTKDTS HCCCCCCEECCCCCC | 53.86 | 24489116 | |
| 1120 | Phosphorylation | DGEEKEVTKDTSNDS CCCCEECCCCCCCCH | 25.05 | 17563356 | |
| 1121 | Acetylation | GEEKEVTKDTSNDSA CCCEECCCCCCCCHH | 65.27 | 24489116 | |
| 1123 | Phosphorylation | EKEVTKDTSNDSAKK CEECCCCCCCCHHHH | 30.87 | 26447709 | |
| 1124 | Phosphorylation | KEVTKDTSNDSAKKE EECCCCCCCCHHHHH | 49.09 | 26447709 | |
| 1127 | Phosphorylation | TKDTSNDSAKKEEAL CCCCCCCHHHHHHHH | 46.36 | 26447709 | |
| 1130 | Acetylation | TSNDSAKKEEALDTA CCCCHHHHHHHHHHH | 61.58 | 24489116 | |
| 1136 | Phosphorylation | KKEEALDTAVKLIKE HHHHHHHHHHHHHHH | 33.91 | 21126336 | |
| 1139 | Acetylation | EALDTAVKLIKERIA HHHHHHHHHHHHHHH | 41.87 | 24489116 | |
| 1174 | Phosphorylation | MIVGPGGSNIKKIRE EEECCCCCCHHHHHH | 41.10 | 28889911 | |
| 1206 | 2-Hydroxyisobutyrylation | VVYIRGTKAGVEKAG EEEECCCCCHHHHHH | 46.06 | - | |
| 1211 | Acetylation | GTKAGVEKAGEMVLK CCCCHHHHHHHHHHH | 60.32 | 24489116 | |
| 1218 | Acetylation | KAGEMVLKSLRR--- HHHHHHHHHHCC--- | 35.71 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SC160_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SC160_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SC160_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-50; SER-54; SER-60;SER-63; SER-87; SER-325; SER-630; SER-1019; SER-1109 AND SER-1112, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-50; SER-54; SER-1112 ANDTHR-1120, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-50; SER-85 AND SER-89,AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1112, AND MASSSPECTROMETRY. | |
