RL4B_YEAST - dbPTM
RL4B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL4B_YEAST
UniProt AC P49626
Protein Name 60S ribosomal protein L4-B {ECO:0000303|PubMed:9559554}
Gene Name RPL4B {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 362
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MSRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQTSAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRYATASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLKVLKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAPGAHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIRPAGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFAETLKHD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSRPQVTVH
------CCCCCEEEE		53.301544921
2Phosphorylation------MSRPQVTVH
------CCCCCEEEE		53.3021126336
10PhosphorylationRPQVTVHSLTGEATA
CCCEEEEECCCCCCC		24.2424961812
12PhosphorylationQVTVHSLTGEATANA
CEEEEECCCCCCCCC		35.6724961812
16PhosphorylationHSLTGEATANALPLP
EECCCCCCCCCCCCC		19.0124961812
53PhosphorylationKRQAYAVSEKAGHQT
CHHEEEEECCCCCCC		25.8023749301
55UbiquitinationQAYAVSEKAGHQTSA
HEEEEECCCCCCCCH		52.7623749301
60PhosphorylationSEKAGHQTSAESWGT
ECCCCCCCCHHHHCC		24.9922369663
61PhosphorylationEKAGHQTSAESWGTG
CCCCCCCCHHHHCCC		24.3822369663
64PhosphorylationGHQTSAESWGTGRAV
CCCCCHHHHCCCCCE		30.4423749301
67PhosphorylationTSAESWGTGRAVARI
CCHHHHCCCCCEEEC		19.7528889911
85PhosphorylationGGGGTGRSGQGAFGN
CCCCCCCCCCCCCCC		36.4922369663
104UbiquitinationGRMFAPTKTWRKWNV
CCCCCCCCEEECCEE		45.0623749301
108UbiquitinationAPTKTWRKWNVKVNH
CCCCEEECCEEECCC		34.3822817900
112UbiquitinationTWRKWNVKVNHNEKR
EEECCEEECCCCCHH		33.8222817900
118UbiquitinationVKVNHNEKRYATASA
EECCCCCHHHHHHHH		56.9017644757
120PhosphorylationVNHNEKRYATASAIA
CCCCCHHHHHHHHHH		21.2622369663
122PhosphorylationHNEKRYATASAIAAT
CCCHHHHHHHHHHHH		16.5322369663
124PhosphorylationEKRYATASAIAATAV
CHHHHHHHHHHHHHH		18.8222369663
129PhosphorylationTASAIAATAVASLVL
HHHHHHHHHHHHHHH		16.7922369663
133PhosphorylationIAATAVASLVLARGH
HHHHHHHHHHHHCCC		16.6522369663
144UbiquitinationARGHRVEKIPEIPLV
HCCCCCCCCCCCCEE		61.7823749301
153PhosphorylationPEIPLVVSTDLESIQ
CCCCEEEECCHHHHH		14.5524961812
154PhosphorylationEIPLVVSTDLESIQK
CCCEEEECCHHHHHH		32.7524961812
158PhosphorylationVVSTDLESIQKTKEA
EEECCHHHHHHHHHH		37.3021440633
161UbiquitinationTDLESIQKTKEAVAA
CCHHHHHHHHHHHHH		60.9517644757
163UbiquitinationLESIQKTKEAVAALK
HHHHHHHHHHHHHHH		51.1923749301
170UbiquitinationKEAVAALKAVGAHSD
HHHHHHHHHHHCCHH		35.9823749301
176PhosphorylationLKAVGAHSDLLKVLK
HHHHHCCHHHHHHHH		29.4422369663
180UbiquitinationGAHSDLLKVLKSKKL
HCCHHHHHHHHHCCC		53.4717644757
200PhosphorylationKYRNRRWTQRRGPLV
CCCCCCCHHCCCCEE		15.4717287358
217UbiquitinationAEDNGIVKALRNVPG
ECCCCHHHHHHCCCC		39.5223749301
257UbiquitinationWTEAAFTKLDQVWGS
EEHHHCCCHHHHHCC		43.5423749301
264PhosphorylationKLDQVWGSETVASSK
CHHHHHCCCCCCCCC		17.8730377154
269PhosphorylationWGSETVASSKVGYTL
HCCCCCCCCCCCCCC		26.7619779198
270PhosphorylationGSETVASSKVGYTLP
CCCCCCCCCCCCCCC		22.9421440633
271UbiquitinationSETVASSKVGYTLPS
CCCCCCCCCCCCCCC		36.8623749301
274PhosphorylationVASSKVGYTLPSHII
CCCCCCCCCCCCCEE		14.2126447709
275PhosphorylationASSKVGYTLPSHIIS
CCCCCCCCCCCCEEE		26.6821440633
278PhosphorylationKVGYTLPSHIISTSD
CCCCCCCCCEEEHHH		30.3622369663
282PhosphorylationTLPSHIISTSDVTRI
CCCCCEEEHHHCEEE		22.6622369663
283PhosphorylationLPSHIISTSDVTRII
CCCCEEEHHHCEEEC		20.6622369663
284PhosphorylationPSHIISTSDVTRIIN
CCCEEEHHHCEEECC		24.2422369663
287PhosphorylationIISTSDVTRIINSSE
EEEHHHCEEECCHHH		22.5722369663
292PhosphorylationDVTRIINSSEIQSAI
HCEEECCHHHHHHHH		20.9522369663
293PhosphorylationVTRIINSSEIQSAIR
CEEECCHHHHHHHHC		33.9422369663
297PhosphorylationINSSEIQSAIRPAGQ
CCHHHHHHHHCCCCH		31.1822369663
306PhosphorylationIRPAGQATQKRTHVL
HCCCCHHHHHCCCCC		27.0822369663
308UbiquitinationPAGQATQKRTHVLKK
CCCHHHHHCCCCCCC		55.7123749301
321UbiquitinationKKNPLKNKQVLLRLN
CCCCCCCCEEEEHHC		39.9523749301
332UbiquitinationLRLNPYAKVFAAEKL
EHHCHHHHHHHHHHH		31.8523749301
338UbiquitinationAKVFAAEKLGSKKAE
HHHHHHHHHCCCHHH		54.1223749301
341PhosphorylationFAAEKLGSKKAEKTG
HHHHHHCCCHHHHHC		41.2321440633
342UbiquitinationAAEKLGSKKAEKTGT
HHHHHCCCHHHHHCC		54.9622817900
343UbiquitinationAEKLGSKKAEKTGTK
HHHHCCCHHHHHCCC		64.5722817900
346UbiquitinationLGSKKAEKTGTKPAA
HCCCHHHHHCCCCHH		58.0517644757
347PhosphorylationGSKKAEKTGTKPAAV
CCCHHHHHCCCCHHH		41.4021440633
349PhosphorylationKKAEKTGTKPAAVFA
CHHHHHCCCCHHHHH		38.8021440633
350UbiquitinationKAEKTGTKPAAVFAE
HHHHHCCCCHHHHHH		33.7223749301
350AcetylationKAEKTGTKPAAVFAE
HHHHHCCCCHHHHHH		33.7224489116
360AcetylationAVFAETLKHD-----
HHHHHHHCCC-----		53.8224489116
360SuccinylationAVFAETLKHD-----
HHHHHHHCCC-----		53.8223954790
360UbiquitinationAVFAETLKHD-----
HHHHHHHCCC-----		53.8217644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL4B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL4B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL4B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBI4P_YEASTUBI4physical
20694217
CDC1_YEASTCDC1genetic
27708008
MCM1_YEASTMCM1genetic
27708008
CAP_YEASTSRV2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
UBP3_YEASTUBP3genetic
27708008
ELP2_YEASTELP2genetic
27708008
PPME1_YEASTPPE1genetic
27708008
SNX4_YEASTSNX4genetic
27708008
HAP4_YEASTHAP4genetic
27708008
CBT1_YEASTCBT1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
TMA23_YEASTTMA23genetic
27708008
AEP2_YEASTAEP2genetic
27708008
YNE6_YEASTYNL046Wgenetic
27708008
CTU2_YEASTNCS2genetic
27708008
CY1_YEASTCYT1genetic
27708008
WHI5_YEASTWHI5genetic
27708008
CND2_YEASTBRN1genetic
27708008
IPYR_YEASTIPP1genetic
27708008
ORC2_YEASTORC2genetic
27708008
CALM_YEASTCMD1genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
CDC10_YEASTCDC10genetic
27708008
CDC37_YEASTCDC37genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
ACT_YEASTACT1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
TAF6_YEASTTAF6genetic
27708008
SDA1_YEASTSDA1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
NTR2_YEASTNTR2genetic
27708008
ROT1_YEASTROT1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
UTP23_YEASTUTP23genetic
27708008
MED4_YEASTMED4genetic
27708008
TF2B_YEASTSUA7genetic
27708008
DEP1_YEASTDEP1genetic
27708008
EDE1_YEASTEDE1genetic
27708008
NU170_YEASTNUP170genetic
27708008
MRX3_YEASTYBL095Wgenetic
27708008
RCR1_YEASTRCR1genetic
27708008
RKM3_YEASTRKM3genetic
27708008
RL4A_YEASTRPL4Agenetic
27708008
YBS1_YEASTYBR071Wgenetic
27708008
TPS1_YEASTTPS1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
SEC66_YEASTSEC66genetic
27708008
REI1_YEASTREI1genetic
27708008
SGF29_YEASTSGF29genetic
27708008
AGP1_YEASTAGP1genetic
27708008
YCE2_YEASTYCL042Wgenetic
27708008
RV161_YEASTRVS161genetic
27708008
CWH43_YEASTCWH43genetic
27708008
PER1_YEASTPER1genetic
27708008
SOL2_YEASTSOL2genetic
27708008
FUB1_YEASTFUB1genetic
27708008
UME6_YEASTUME6genetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
PMP3_YEASTPMP3genetic
27708008
RV167_YEASTRVS167genetic
27708008
SNF1_YEASTSNF1genetic
27708008
AK_YEASTHOM3genetic
27708008
BEM2_YEASTBEM2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
HSP12_YEASTHSP12genetic
27708008
BST1_YEASTBST1genetic
27708008
UBP6_YEASTUBP6genetic
27708008
ERV14_YEASTERV14genetic
27708008
SGF73_YEASTSGF73genetic
27708008
AAKG_YEASTSNF4genetic
27708008
COM1_YEASTSAE2genetic
27708008
PEF1_YEASTPEF1genetic
27708008
DBF2_YEASTDBF2genetic
27708008
HGH1_YEASTHGH1genetic
27708008
YG51_YEASTYGR237Cgenetic
27708008
AP3B_YEASTAPL6genetic
27708008
MED20_YEASTSRB2genetic
27708008
TED1_YEASTTED1genetic
27708008
FMC1_YEASTFMC1genetic
27708008
THIK_YEASTPOT1genetic
27708008
YIW2_YEASTYIR042Cgenetic
27708008
GPI7_YEASTLAS21genetic
27708008
GSM1_YEASTGSM1genetic
27708008
CYP7_YEASTCPR7genetic
27708008
MET7_YEASTSTR2genetic
27708008
HIR3_YEASTHIR3genetic
27708008
IXR1_YEASTIXR1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
DOA1_YEASTDOA1genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
PSR1_YEASTPSR1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
SRN2_YEASTSRN2genetic
27708008
ARV1_YEASTARV1genetic
27708008
AP1_YEASTYAP1genetic
27708008
NAB6_YEASTNAB6genetic
27708008
SIP5_YEASTSIP5genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
YM71_YEASTYMR226Cgenetic
27708008
GAS1_YEASTGAS1genetic
27708008
ARK1_YEASTARK1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
PMS1_YEASTPMS1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
MDM12_YEASTMDM12genetic
27708008
IRA2_YEASTIRA2genetic
27708008
YSP3_YEASTYSP3genetic
27708008
HIR2_YEASTHIR2genetic
27708008
GLO4_YEASTGLO4genetic
27708008
WHI2_YEASTWHI2genetic
27708008
YO093_YEASTYOR093Cgenetic
27708008
VAM3_YEASTVAM3genetic
27708008
SFL1_YEASTSFL1genetic
27708008
SERC_YEASTSER1genetic
27708008
PDE2_YEASTPDE2genetic
27708008
BECN1_YEASTVPS30genetic
27708008
ENV7_YEASTENV7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL4B_YEAST

loading...

Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"NH2-terminal acetylation of ribosomal proteins of Saccharomycescerevisiae.";
Takakura H., Tsunasawa S., Miyagi M., Warner J.R.;
J. Biol. Chem. 267:5442-5445(1992).
Cited for: PROTEIN SEQUENCE OF 2-21, AND ACETYLATION AT SER-2 BY NATA.
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122; SER-124; THR-129AND SER-133, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory