EDE1_YEAST - dbPTM
EDE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EDE1_YEAST
UniProt AC P34216
Protein Name EH domain-containing and endocytosis protein 1
Gene Name EDE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1381
Subcellular Localization Cytoplasm . Localized to actin cortical patches concentrated in the developing bud tip in cells with small buds and at the mother-daughter neck in cells undergoing cytokinesis. Localization can be maintained in the absence of polymerized actin filame
Protein Description Functions at the internalization step of the clathrin-mediated endocytosis (CME) as an early-acting scaffold protein. Requires clathrin adapter proteins, ENT1/2 and YAP1801/2, for normal spatiotemporal dynamics and viability. Binds to biological membranes in a ubiquitin-dependent manner..
Protein Sequence MASITFRTPLSSQEQAFYNQKFHQLDTEDLGVVTGEAVRPLFASSGLPGQLLSQVWATVDIDNKGFLNLNEFSAALRMIAQLQNAPNQPISAALYESTPTQLASFSINQNPAPMQSGSATGNTNNTDIPALSSNDIAKFSQLFDRTAKGAQTVAGDKAKDIFLKARLPNQTLGEIWALCDRDASGVLDKSEFIMAMYLIQLCMSHHPSMNTPPAVLPTQLWDSIRLEPVVVNQPNRTTPLSANSTGVSSLTRHSTISRLSTGAFSNAASDWSLSFEKKQQFDAIFDSLDKQHAGSLSSAVLVPFFLSSRLNQETLATIWDLADIHNNAEFTKLEFAIAMFLIQKKNAGVELPDVIPNELLQSPALGLYPPNPLPQQQSAPQIAIPSRASKPSLQDMPHQVSAPAVNTQPTVPQVLPQNSNNGSLNDLLALNPSFSSPSPTKAQTVVQNNTNNSFSYDNNNGQATLQQQQPQQPPPLTHSSSGLKKFTPTSNFGQSIIKEEPEEQEQLRESSDTFSAQPPPVPKHASSPVKRTASTTLPQVPNFSVFSMPAGAATSAATGAAVGAAVGAAALGASAFSRSSNNAFKNQDLFADGEASAQLSNATTEMANLSNQVNSLSKQASITNDKKSRATQELKRVTEMKNSIQIKLNNLRSTHDQNVKQTEQLEAQVLQVNKENETLAQQLAVSEANYHAAESKLNELTTDLQESQTKNAELKEQITNLNSMTASLQSQLNEKQQQVKQERSMVDVNSKQLELNQVTVANLQKEIDGLGEKISVYLTKQKELNDYQKTVEEQHAQLQAKYQDLSNKDTDLTDREKQLEERNRQIEEQENLYHQHVSKLQEMFDDLSQRKASFEKADQELKERNIEYANNVRELSERQMNLAMGQLPEDAKDIIAKSASNTDTTTKEATSRGNVHEDTVSKFVETTVENSNLNVNRVKDDEEKTERTESDVFDRDVPTLGSQSDSENANTNNGTQSGNETANPNLTETLSDRFDGDLNEYGIPRSQSLTSSVANNAPQSVRDDVELPETLEERDTINNTANRDNTGNLSHIPGEWEATPATASTDVLSNETTEVIEDGSTTKRANSNEDGESVSSIQESPKISAQPKAKTINEEFPPIQELHIDESDSSSSDDDEFEDTREIPSATVKTLQTPYNAQPTSSLEIHTEQVIKYPAPGTSPSHNEGNSKKASTNSILPVKDEFDDEFAGLEQAAVEEDNGADSESEFENVANAGSMEQFETIDHKDLDDELQMNAFTGTLTSSSNPTIPKPQVQQQSTSDPAQVSNDEWDEIFAGFGNSKAEPTKVATPSIPQQPIPLKNDPIVDASLSKGPIVNRGVATTPKSLAVEELSGMGFTEEEAHNALEKCNWDLEAATNFLLDSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASITFRTPL
-----CCCEEEECCC		33.7428152593
5Phosphorylation---MASITFRTPLSS
---CCCEEEECCCCH		12.4528132839
11PhosphorylationITFRTPLSSQEQAFY
EEEECCCCHHHHHHH		31.0428889911
21UbiquitinationEQAFYNQKFHQLDTE
HHHHHHHCCCCCCHH		40.9717644757
100PhosphorylationALYESTPTQLASFSI
HHHCCCCCEEHHEEC		35.9828889911
104PhosphorylationSTPTQLASFSINQNP
CCCCEEHHEECCCCC		28.2828889911
1572-HydroxyisobutyrylationAQTVAGDKAKDIFLK
CCHHCCHHHHHHHHH		57.32-
157UbiquitinationAQTVAGDKAKDIFLK
CCHHCCHHHHHHHHH		57.3223749301
159UbiquitinationTVAGDKAKDIFLKAR
HHCCHHHHHHHHHCC		58.0322817900
164UbiquitinationKAKDIFLKARLPNQT
HHHHHHHHCCCCCCC		22.2522817900
190PhosphorylationASGVLDKSEFIMAMY
CCCCCCHHHHHHHHH		37.0923749301
197PhosphorylationSEFIMAMYLIQLCMS
HHHHHHHHHHHHHHH		7.3623749301
204PhosphorylationYLIQLCMSHHPSMNT
HHHHHHHHCCCCCCC		20.0423749301
208PhosphorylationLCMSHHPSMNTPPAV
HHHHCCCCCCCCCCC		21.9523749301
237PhosphorylationVVNQPNRTTPLSANS
EECCCCCCCCCCCCC		39.1322369663
238PhosphorylationVNQPNRTTPLSANST
ECCCCCCCCCCCCCC		20.9922369663
241PhosphorylationPNRTTPLSANSTGVS
CCCCCCCCCCCCCCC		26.9722369663
244PhosphorylationTTPLSANSTGVSSLT
CCCCCCCCCCCCHHH		26.6722369663
245PhosphorylationTPLSANSTGVSSLTR
CCCCCCCCCCCHHHC		41.2222369663
248PhosphorylationSANSTGVSSLTRHST
CCCCCCCCHHHCCCH		22.4522369663
249PhosphorylationANSTGVSSLTRHSTI
CCCCCCCHHHCCCHH		31.2122369663
251PhosphorylationSTGVSSLTRHSTISR
CCCCCHHHCCCHHHH		28.4322369663
254PhosphorylationVSSLTRHSTISRLST
CCHHHCCCHHHHCCC		24.9322369663
255PhosphorylationSSLTRHSTISRLSTG
CHHHCCCHHHHCCCC		19.4922369663
257PhosphorylationLTRHSTISRLSTGAF
HHCCCHHHHCCCCCC		27.5322369663
260PhosphorylationHSTISRLSTGAFSNA
CCHHHHCCCCCCCCC		24.5522369663
261PhosphorylationSTISRLSTGAFSNAA
CHHHHCCCCCCCCCC		36.8022369663
265PhosphorylationRLSTGAFSNAASDWS
HCCCCCCCCCCCCCC		25.6522369663
269PhosphorylationGAFSNAASDWSLSFE
CCCCCCCCCCCCCCC		36.8821440633
272PhosphorylationSNAASDWSLSFEKKQ
CCCCCCCCCCCCHHH		21.0822369663
274PhosphorylationAASDWSLSFEKKQQF
CCCCCCCCCCHHHHH		26.3322369663
378PhosphorylationNPLPQQQSAPQIAIP
CCCCCCCCCCCCCCC		37.2630377154
389PhosphorylationIAIPSRASKPSLQDM
CCCCCCCCCCCHHCC		43.9521551504
392PhosphorylationPSRASKPSLQDMPHQ
CCCCCCCCHHCCCCC		42.2627738172
401PhosphorylationQDMPHQVSAPAVNTQ
HCCCCCCCCCCCCCC		23.2027738172
419PhosphorylationPQVLPQNSNNGSLND
CCCCCCCCCCCCHHH		26.8228889911
423PhosphorylationPQNSNNGSLNDLLAL
CCCCCCCCHHHHHHH		26.5628889911
433PhosphorylationDLLALNPSFSSPSPT
HHHHHCCCCCCCCCC		36.3728889911
435PhosphorylationLALNPSFSSPSPTKA
HHHCCCCCCCCCCCC		45.7527738172
436PhosphorylationALNPSFSSPSPTKAQ
HHCCCCCCCCCCCCC		27.6427738172
438PhosphorylationNPSFSSPSPTKAQTV
CCCCCCCCCCCCCEE		47.3428889911
440PhosphorylationSFSSPSPTKAQTVVQ
CCCCCCCCCCCEEEE		43.2627738172
444PhosphorylationPSPTKAQTVVQNNTN
CCCCCCCEEEECCCC		27.7529136822
450PhosphorylationQTVVQNNTNNSFSYD
CEEEECCCCCCCEEC		43.2419823750
453PhosphorylationVQNNTNNSFSYDNNN
EECCCCCCCEECCCC		20.0320377248
455PhosphorylationNNTNNSFSYDNNNGQ
CCCCCCCEECCCCCE		31.2520377248
456PhosphorylationNTNNSFSYDNNNGQA
CCCCCCEECCCCCEE		22.2220377248
464PhosphorylationDNNNGQATLQQQQPQ
CCCCCEEECCCCCCC		19.7420377248
477PhosphorylationPQQPPPLTHSSSGLK
CCCCCCCCCCCCCCC		26.0320377248
479PhosphorylationQPPPLTHSSSGLKKF
CCCCCCCCCCCCCCC		22.4420377248
480PhosphorylationPPPLTHSSSGLKKFT
CCCCCCCCCCCCCCC		22.3320377248
481PhosphorylationPPLTHSSSGLKKFTP
CCCCCCCCCCCCCCC		51.6820377248
485AcetylationHSSSGLKKFTPTSNF
CCCCCCCCCCCCCCC		60.5625381059
487PhosphorylationSSGLKKFTPTSNFGQ
CCCCCCCCCCCCCCC		34.2422369663
489PhosphorylationGLKKFTPTSNFGQSI
CCCCCCCCCCCCCHH		32.9922369663
490PhosphorylationLKKFTPTSNFGQSII
CCCCCCCCCCCCHHH		31.2225521595
495PhosphorylationPTSNFGQSIIKEEPE
CCCCCCCHHHHCCHH		27.0225521595
498AcetylationNFGQSIIKEEPEEQE
CCCCHHHHCCHHHHH		55.1224489116
498UbiquitinationNFGQSIIKEEPEEQE
CCCCHHHHCCHHHHH		55.1223749301
510PhosphorylationEQEQLRESSDTFSAQ
HHHHHHHCCCCCCCC		27.3829136822
511PhosphorylationQEQLRESSDTFSAQP
HHHHHHCCCCCCCCC		35.6029136822
513PhosphorylationQLRESSDTFSAQPPP
HHHHCCCCCCCCCCC		22.8025521595
515PhosphorylationRESSDTFSAQPPPVP
HHCCCCCCCCCCCCC		28.2525521595
526PhosphorylationPPVPKHASSPVKRTA
CCCCCCCCCCCCCCC		34.5924909858
527PhosphorylationPVPKHASSPVKRTAS
CCCCCCCCCCCCCCC		34.2019823750
534PhosphorylationSPVKRTASTTLPQVP
CCCCCCCCCCCCCCC		22.7028889911
579PhosphorylationGASAFSRSSNNAFKN
CHHHHCCCCCCCCCC		35.9027214570
580PhosphorylationASAFSRSSNNAFKNQ
HHHHCCCCCCCCCCC		32.7525752575
585UbiquitinationRSSNNAFKNQDLFAD
CCCCCCCCCCCCCCC		51.8217644757
603PhosphorylationSAQLSNATTEMANLS
HHHHCHHHHHHHHHH		27.7828889911
621PhosphorylationNSLSKQASITNDKKS
HHHHHHHHCCCCHHH		27.7028889911
628PhosphorylationSITNDKKSRATQELK
HCCCCHHHHHHHHHH		32.6530377154
631PhosphorylationNDKKSRATQELKRVT
CCHHHHHHHHHHHHH		22.8223749301
635SuccinylationSRATQELKRVTEMKN
HHHHHHHHHHHHHHH		44.0323954790
647AcetylationMKNSIQIKLNNLRST
HHHHHHHHHHCCCCC		28.8724489116
674UbiquitinationAQVLQVNKENETLAQ
HHHHHHHHCCHHHHH		64.1622106047
744PhosphorylationQQVKQERSMVDVNSK
HHHHHHHHHCCCCHH		23.5422369663
780UbiquitinationKISVYLTKQKELNDY
HHHEEEECHHHHCHH		57.7023749301
782UbiquitinationSVYLTKQKELNDYQK
HEEEECHHHHCHHHH		66.7723749301
789AcetylationKELNDYQKTVEEQHA
HHHCHHHHHHHHHHH		48.5924489116
808AcetylationKYQDLSNKDTDLTDR
HHHHHCCCCCCCHHH		59.6424489116
817AcetylationTDLTDREKQLEERNR
CCCHHHHHHHHHHHH		62.1624489116
848PhosphorylationQEMFDDLSQRKASFE
HHHHHHHHHHHHHHH		34.6322369663
853PhosphorylationDLSQRKASFEKADQE
HHHHHHHHHHHHHHH		36.6524961812
892UbiquitinationGQLPEDAKDIIAKSA
CCCCHHHHHHHHHHC		62.8823749301
897UbiquitinationDAKDIIAKSASNTDT
HHHHHHHHHCCCCCC		35.8323749301
898PhosphorylationAKDIIAKSASNTDTT
HHHHHHHHCCCCCCC		28.1023749301
900PhosphorylationDIIAKSASNTDTTTK
HHHHHHCCCCCCCCC		47.5625752575
902PhosphorylationIAKSASNTDTTTKEA
HHHHCCCCCCCCCHH		32.0229136822
904PhosphorylationKSASNTDTTTKEATS
HHCCCCCCCCCHHHH		34.0323749301
907UbiquitinationSNTDTTTKEATSRGN
CCCCCCCCHHHHCCC		43.1723749301
910PhosphorylationDTTTKEATSRGNVHE
CCCCCHHHHCCCCCH		21.7629136822
911PhosphorylationTTTKEATSRGNVHED
CCCCHHHHCCCCCHH		45.2817287358
919PhosphorylationRGNVHEDTVSKFVET
CCCCCHHHHHHHHHH		24.5619823750
921PhosphorylationNVHEDTVSKFVETTV
CCCHHHHHHHHHHHH		23.5919823750
922AcetylationVHEDTVSKFVETTVE
CCHHHHHHHHHHHHH		49.4424489116
922UbiquitinationVHEDTVSKFVETTVE
CCHHHHHHHHHHHHH		49.4424961812
926PhosphorylationTVSKFVETTVENSNL
HHHHHHHHHHHCCCC		30.7328889911
927PhosphorylationVSKFVETTVENSNLN
HHHHHHHHHHCCCCC		16.5922369663
931PhosphorylationVETTVENSNLNVNRV
HHHHHHCCCCCCEEC		29.2322369663
945PhosphorylationVKDDEEKTERTESDV
CCCHHHHHHHCHHHH		33.7022369663
948PhosphorylationDEEKTERTESDVFDR
HHHHHHHCHHHHCCC		33.3422890988
950PhosphorylationEKTERTESDVFDRDV
HHHHHCHHHHCCCCC		38.1622369663
959PhosphorylationVFDRDVPTLGSQSDS
HCCCCCCCCCCCCCC		43.5319795423
962PhosphorylationRDVPTLGSQSDSENA
CCCCCCCCCCCCCCC		29.6219795423
964PhosphorylationVPTLGSQSDSENANT
CCCCCCCCCCCCCCC		44.8119795423
966PhosphorylationTLGSQSDSENANTNN
CCCCCCCCCCCCCCC		37.6919795423
971PhosphorylationSDSENANTNNGTQSG
CCCCCCCCCCCCCCC		27.8719795423
975PhosphorylationNANTNNGTQSGNETA
CCCCCCCCCCCCCCC		22.9919795423
977PhosphorylationNTNNGTQSGNETANP
CCCCCCCCCCCCCCC		43.3419795423
1006PhosphorylationNEYGIPRSQSLTSSV
HHCCCCHHHHHCHHH		20.8322369663
1008PhosphorylationYGIPRSQSLTSSVAN
CCCCHHHHHCHHHHH		34.5622369663
1010PhosphorylationIPRSQSLTSSVANNA
CCHHHHHCHHHHHCC		24.9722369663
1011PhosphorylationPRSQSLTSSVANNAP
CHHHHHCHHHHHCCC		28.2722369663
1012PhosphorylationRSQSLTSSVANNAPQ
HHHHHCHHHHHCCCC		21.7322369663
1020PhosphorylationVANNAPQSVRDDVEL
HHHCCCCCHHCCCCC		20.3322369663
1030PhosphorylationDDVELPETLEERDTI
CCCCCCHHHHHHHCC		37.2122369663
1036PhosphorylationETLEERDTINNTANR
HHHHHHHCCCCCCCC		31.6528889911
1040PhosphorylationERDTINNTANRDNTG
HHHCCCCCCCCCCCC		22.3328889911
1046PhosphorylationNTANRDNTGNLSHIP
CCCCCCCCCCCCCCC		31.5622369663
1050PhosphorylationRDNTGNLSHIPGEWE
CCCCCCCCCCCCCCC		24.3022369663
1059PhosphorylationIPGEWEATPATASTD
CCCCCCCCCCCCCCC		11.2722369663
1062PhosphorylationEWEATPATASTDVLS
CCCCCCCCCCCCCCC		23.5022369663
1064PhosphorylationEATPATASTDVLSNE
CCCCCCCCCCCCCCC		22.3022369663
1065PhosphorylationATPATASTDVLSNET
CCCCCCCCCCCCCCC		27.8822369663
1069PhosphorylationTASTDVLSNETTEVI
CCCCCCCCCCCEEEE		32.2522369663
1072PhosphorylationTDVLSNETTEVIEDG
CCCCCCCCEEEEECC		32.2922369663
1073PhosphorylationDVLSNETTEVIEDGS
CCCCCCCEEEEECCC		23.2922369663
1080PhosphorylationTEVIEDGSTTKRANS
EEEEECCCCCCCCCC		45.2722369663
1081PhosphorylationEVIEDGSTTKRANSN
EEEECCCCCCCCCCC		41.6922369663
1082PhosphorylationVIEDGSTTKRANSNE
EEECCCCCCCCCCCC		21.8922369663
1083UbiquitinationIEDGSTTKRANSNED
EECCCCCCCCCCCCC		49.9923749301
1087PhosphorylationSTTKRANSNEDGESV
CCCCCCCCCCCCCCH		40.3822369663
1093PhosphorylationNSNEDGESVSSIQES
CCCCCCCCHHHHHCC		32.5922369663
1095PhosphorylationNEDGESVSSIQESPK
CCCCCCHHHHHCCCC		30.8822369663
1096PhosphorylationEDGESVSSIQESPKI
CCCCCHHHHHCCCCC		26.5722369663
1100PhosphorylationSVSSIQESPKISAQP
CHHHHHCCCCCCCCC		18.3422369663
1102UbiquitinationSSIQESPKISAQPKA
HHHHCCCCCCCCCCC		59.5823749301
1104PhosphorylationIQESPKISAQPKAKT
HHCCCCCCCCCCCCC		27.2922369663
1108UbiquitinationPKISAQPKAKTINEE
CCCCCCCCCCCCCCC		50.8923749301
1111PhosphorylationSAQPKAKTINEEFPP
CCCCCCCCCCCCCCC		33.6219795423
1127PhosphorylationQELHIDESDSSSSDD
EEEEECCCCCCCCCC		38.7619795423
1129PhosphorylationLHIDESDSSSSDDDE
EEECCCCCCCCCCCC		41.2019795423
1130PhosphorylationHIDESDSSSSDDDEF
EECCCCCCCCCCCCC		38.5621440633
1131PhosphorylationIDESDSSSSDDDEFE
ECCCCCCCCCCCCCC		41.5619795423
1132PhosphorylationDESDSSSSDDDEFED
CCCCCCCCCCCCCCC		47.1819795423
1140PhosphorylationDDDEFEDTREIPSAT
CCCCCCCHHCCCCCE		24.0119795423
1145PhosphorylationEDTREIPSATVKTLQ
CCHHCCCCCEEEEEC		42.0819795423
1147PhosphorylationTREIPSATVKTLQTP
HHCCCCCEEEEECCC		27.2019795423
1149UbiquitinationEIPSATVKTLQTPYN
CCCCCEEEEECCCCC		38.8823749301
1155PhosphorylationVKTLQTPYNAQPTSS
EEEECCCCCCCCCCC		26.9022369663
1160PhosphorylationTPYNAQPTSSLEIHT
CCCCCCCCCCEEEEE		20.9022369663
1161PhosphorylationPYNAQPTSSLEIHTE
CCCCCCCCCEEEEEE		39.3422369663
1162PhosphorylationYNAQPTSSLEIHTEQ
CCCCCCCCEEEEEEE		32.2822369663
1167PhosphorylationTSSLEIHTEQVIKYP
CCCEEEEEEEEEECC		33.5020377248
1172UbiquitinationIHTEQVIKYPAPGTS
EEEEEEEECCCCCCC		46.4524961812
1173PhosphorylationHTEQVIKYPAPGTSP
EEEEEEECCCCCCCC		8.1022890988
1178PhosphorylationIKYPAPGTSPSHNEG
EECCCCCCCCCCCCC		36.0822369663
1179PhosphorylationKYPAPGTSPSHNEGN
ECCCCCCCCCCCCCC		30.2522369663
1181PhosphorylationPAPGTSPSHNEGNSK
CCCCCCCCCCCCCCC		38.4222369663
1187PhosphorylationPSHNEGNSKKASTNS
CCCCCCCCCCCCCCC		46.5222369663
1191PhosphorylationEGNSKKASTNSILPV
CCCCCCCCCCCCCCC		36.6822369663
1192PhosphorylationGNSKKASTNSILPVK
CCCCCCCCCCCCCCC		37.5322369663
1194PhosphorylationSKKASTNSILPVKDE
CCCCCCCCCCCCCCC		26.1222369663
1256PhosphorylationELQMNAFTGTLTSSS
HHHHHHHCCEECCCC		27.1821551504
1258PhosphorylationQMNAFTGTLTSSSNP
HHHHHCCEECCCCCC		24.6524961812
1262PhosphorylationFTGTLTSSSNPTIPK
HCCEECCCCCCCCCC		28.9721551504
1263PhosphorylationTGTLTSSSNPTIPKP
CCEECCCCCCCCCCC		46.7421551504
1276PhosphorylationKPQVQQQSTSDPAQV
CCCCCCCCCCCHHHC		26.0724961812
1277PhosphorylationPQVQQQSTSDPAQVS
CCCCCCCCCCHHHCC		32.5821551504
1278PhosphorylationQVQQQSTSDPAQVSN
CCCCCCCCCHHHCCH		47.0124961812
1284PhosphorylationTSDPAQVSNDEWDEI
CCCHHHCCHHHHHHH		26.8722369663
1303PhosphorylationGNSKAEPTKVATPSI
CCCCCCCCCCCCCCC		29.6529136822
1304UbiquitinationNSKAEPTKVATPSIP
CCCCCCCCCCCCCCC		40.3623749301
1307PhosphorylationAEPTKVATPSIPQQP
CCCCCCCCCCCCCCC		22.1322369663
1309PhosphorylationPTKVATPSIPQQPIP
CCCCCCCCCCCCCCC		42.4122369663
1318AcetylationPQQPIPLKNDPIVDA
CCCCCCCCCCCCCCC		54.6824489116
1318UbiquitinationPQQPIPLKNDPIVDA
CCCCCCCCCCCCCCC		54.6823749301
1326PhosphorylationNDPIVDASLSKGPIV
CCCCCCCHHCCCCCC		28.8122369663
1328PhosphorylationPIVDASLSKGPIVNR
CCCCCHHCCCCCCCC		32.8322369663
1329UbiquitinationIVDASLSKGPIVNRG
CCCCHHCCCCCCCCC		74.1923749301
1339PhosphorylationIVNRGVATTPKSLAV
CCCCCCCCCCHHHHH		41.0225521595
1340PhosphorylationVNRGVATTPKSLAVE
CCCCCCCCCHHHHHH		20.9825521595
1343PhosphorylationGVATTPKSLAVEELS
CCCCCCHHHHHHHHC		23.8222369663
1350PhosphorylationSLAVEELSGMGFTEE
HHHHHHHCCCCCCHH		29.9722369663
1355PhosphorylationELSGMGFTEEEAHNA
HHCCCCCCHHHHHHH		36.4422369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EDE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EDE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EDE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLA2_YEASTSLA2physical
11805826
SYP1_YEASTSYP1physical
11805826
PAL1_YEASTPAL1physical
11805826
AP18B_YEASTYAP1802physical
11940605
END3_YEASTEND3genetic
10954428
PAN1_YEASTPAN1genetic
10954428
RSP5_YEASTRSP5genetic
10954428
RPA34_YEASTRPA34physical
16554755
SYP1_YEASTSYP1physical
16429126
SLA2_YEASTSLA2physical
16429126
PAL1_YEASTPAL1physical
16429126
RL2A_YEASTRPL2Aphysical
16429126
RL2B_YEASTRPL2Aphysical
16429126
UBI4P_YEASTUBI4physical
16563434
AP18B_YEASTYAP1802physical
18719252
SYP1_YEASTSYP1physical
18719252
EDE1_YEASTEDE1physical
19591838
SGM1_YEASTSGM1physical
19591838
SYP1_YEASTSYP1physical
19713939
SYP1_YEASTSYP1genetic
19713939
UBI4P_YEASTUBI4physical
19903324
ECM33_YEASTECM33genetic
20093466
SIF2_YEASTSIF2genetic
20093466
SEC66_YEASTSEC66genetic
20093466
KAR4_YEASTKAR4genetic
20093466
ABP1_YEASTABP1genetic
20093466
HOSC_YEASTLYS20genetic
20093466
CYK3_YEASTCYK3genetic
20093466
MTU1_YEASTSLM3genetic
20093466
MNN10_YEASTMNN10genetic
20093466
EMI1_YEASTEMI1genetic
20093466
SPS2_YEASTSPS2genetic
20093466
VAM7_YEASTVAM7genetic
20093466
HUR1_YEASTHUR1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
ASK10_YEASTASK10genetic
20093466
SMI1_YEASTSMI1genetic
20093466
SLT2_YEASTSLT2genetic
20093466
APQ12_YEASTAPQ12genetic
20093466
CAPZB_YEASTCAP2genetic
20093466
MNN11_YEASTMNN11genetic
20093466
PBS2_YEASTPBS2genetic
20093466
CHS6_YEASTCHS6genetic
20093466
BCK1_YEASTBCK1genetic
20093466
HOC1_YEASTHOC1genetic
20093466
CANB_YEASTCNB1genetic
20093466
PGM1_YEASTPGM1genetic
20093466
MDM35_YEASTMDM35genetic
20093466
TCD2_YEASTTCD2genetic
20093466
CAPZA_YEASTCAP1genetic
20093466
KAPS_YEASTMET14genetic
20093466
UTH1_YEASTUTH1genetic
20093466
CCW12_YEASTCCW12genetic
20093466
ENT2_YEASTENT2genetic
20093466
CHS5_YEASTCHS5genetic
20093466
FKS1_YEASTFKS1genetic
20093466
ELO3_YEASTELO3genetic
20093466
MSS1_YEASTMSS1genetic
20093466
SUB1_YEASTSUB1genetic
20093466
MOT3_YEASTMOT3genetic
20093466
KC12_YEASTYCK2genetic
20093466
PHO23_YEASTPHO23genetic
20093466
MKS1_YEASTMKS1genetic
20093466
BRE5_YEASTBRE5genetic
20093466
YOR31_YEASTYOR131Cgenetic
20093466
RUD3_YEASTRUD3genetic
20093466
FLC1_YEASTFLC1genetic
20093466
YP066_YEASTRGL1genetic
20093466
THP3_YEASTTHP3genetic
20093466
CCW12_YEASTCCW12genetic
19325107
GLO3_YEASTGLO3genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
SKY1_YEASTSKY1genetic
19325107
CALX_YEASTCNE1genetic
19325107
KEX2_YEASTKEX2genetic
19325107
MSC1_YEASTMSC1genetic
19325107
RER1_YEASTRER1genetic
19325107
GLU2A_YEASTROT2genetic
19325107
TAPT1_YEASTEMP65genetic
19325107
SYP1_YEASTSYP1physical
20826334
GUP1_YEASTGUP1genetic
20526336
SLA1_YEASTSLA1genetic
20526336
TPM1_YEASTTPM1genetic
20526336
RGD1_YEASTRGD1genetic
20526336
SLT2_YEASTSLT2genetic
20526336
HKR1_YEASTHKR1genetic
20526336
FAB1_YEASTFAB1genetic
20526336
VPS27_YEASTVPS27genetic
20526336
PFD2_YEASTGIM4genetic
20526336
WHI2_YEASTWHI2genetic
20526336
ELM1_YEASTELM1genetic
20526336
SAC1_YEASTSAC1genetic
20526336
PEP12_YEASTPEP12genetic
20526336
ENT2_YEASTENT2genetic
20526336
SRS2_YEASTSRS2genetic
21459050
UBI4P_YEASTUBI4physical
19620964
EDE1_YEASTEDE1physical
19620964
PXA1_YEASTPXA1physical
22190733
SPC72_YEASTSPC72physical
22875988
EDE1_YEASTEDE1physical
22875988
ARE1_YEASTARE1physical
22875988
YEF3_YEASTYEL043Wphysical
22875988
RSC8_YEASTRSC8physical
22875988
SEC9_YEASTSEC9physical
22875988
SPR3_YEASTSPR3physical
22875988
ETP1_YEASTETP1physical
22875988
SGM1_YEASTSGM1physical
22875988
END3_YEASTEND3physical
22875988
PBS2_YEASTPBS2genetic
22282571
UBI4P_YEASTUBI4physical
16007098
VPS51_YEASTVPS51genetic
27708008
ARV1_YEASTARV1genetic
27708008
ERG6_YEASTERG6genetic
27708008
SSO2_YEASTSSO2genetic
27708008
SIF2_YEASTSIF2genetic
27708008
NPL4_YEASTNPL4genetic
27708008
KAR4_YEASTKAR4genetic
27708008
ABP1_YEASTABP1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
CYK3_YEASTCYK3genetic
27708008
MNN10_YEASTMNN10genetic
27708008
ERD1_YEASTERD1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
PCL6_YEASTPCL6genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
PTH_YEASTPTH1genetic
27708008
CAPZB_YEASTCAP2genetic
27708008
BCK1_YEASTBCK1genetic
27708008
MDV1_YEASTMDV1genetic
27708008
PBS2_YEASTPBS2genetic
27708008
HOC1_YEASTHOC1genetic
27708008
ILM1_YEASTILM1genetic
27708008
CAPZA_YEASTCAP1genetic
27708008
TCD2_YEASTTCD2genetic
27708008
AIM26_YEASTAIM26genetic
27708008
MDM35_YEASTMDM35genetic
27708008
PGM1_YEASTPGM1genetic
27708008
CANB_YEASTCNB1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
PAM17_YEASTPAM17genetic
27708008
RL40A_YEASTRPL40Bgenetic
27708008
RL40B_YEASTRPL40Bgenetic
27708008
PER33_YEASTPER33genetic
27708008
ALAM_YEASTALT1genetic
27708008
CCW12_YEASTCCW12genetic
27708008
SWI6_YEASTSWI6genetic
27708008
PFD6_YEASTYKE2genetic
27708008
ENT2_YEASTENT2genetic
27708008
MMS22_YEASTMMS22genetic
27708008
CHS5_YEASTCHS5genetic
27708008
FKS1_YEASTFKS1genetic
27708008
ELO3_YEASTELO3genetic
27708008
AIM34_YEASTAIM34genetic
27708008
SUB1_YEASTSUB1genetic
27708008
MOT3_YEASTMOT3genetic
27708008
BRE5_YEASTBRE5genetic
27708008
RTC1_YEASTRTC1genetic
27708008
ODC2_YEASTODC2genetic
27708008
TBCA_YEASTRBL2genetic
27708008
YP066_YEASTRGL1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
FLC1_YEASTFLC1genetic
27708008
THP3_YEASTTHP3genetic
27708008
SEC4_YEASTSEC4genetic
27526190
HRR25_YEASTHRR25physical
25625208
EDE1_YEASTEDE1physical
25366307
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EDE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-238; SER-241; SER-244;THR-245; SER-248; SER-249; THR-251; THR-261; SER-265; SER-419;SER-423; SER-433; SER-438; THR-487; THR-489; SER-495; SER-511;THR-513; SER-534; THR-603; SER-848; SER-931; SER-950; SER-964;SER-1006; SER-1008; SER-1011; SER-1012; SER-1020; THR-1062; SER-1064;THR-1065; SER-1069; THR-1072; SER-1087; SER-1093; SER-1095; SER-1096;SER-1100; THR-1111; THR-1160; SER-1161; THR-1178; SER-1181; THR-1307;SER-1309; THR-1339; THR-1340 AND SER-1343, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; SER-244; SER-527;SER-1006; SER-1008; SER-1087; SER-1093; SER-1095; SER-1096; SER-1100;SER-1179; THR-1340 AND SER-1343, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911; SER-1093; SER-1095;SER-1100; SER-1179; SER-1181 AND THR-1340, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-238; SER-241; SER-244;THR-245; SER-248; SER-249; THR-487; SER-1093; SER-1096; SER-1100 ANDTHR-1307, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; THR-245 ANDTHR-1307, AND MASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; THR-245 ANDTHR-1340, AND MASS SPECTROMETRY.

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