TAPT1_YEAST - dbPTM
TAPT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAPT1_YEAST
UniProt AC P40085
Protein Name Endoplasmic reticulum membrane protein 65 {ECO:0000305|PubMed:23275891}
Gene Name EMP65 {ECO:0000303|PubMed:23275891}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 556
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Mitochondrion .
Protein Description May be involved in membrane protein folding..
Protein Sequence MQHKDTAVAKDTAKKRLLRRNSAPSAIHIISRLDKKWSFLWNTIDRHNIVEEQDESSAAKSEEEHEDDYELEQLLNMIRIPMFLEKFMLFALLTSLDCFLYYFTVLPIRLIKGYVKQFKSYRQHYRLQQRSGHKNKIPFRYRITSREYKERCMIFIIVISSILLSKLDTSKLYHRIKRQSTMKLYMLFSVLEMADKMLASLGQSLLTVMLSRKNSERILLHKCLLVSMSLTYVTIHGYVLVYQAISLNIAVNSYSNALLTLLLSMQFAEIKSSVLKKFDKEGFFQITIADVVERFKLTLLLSITGLRNLQSWSSSLSNTSINFWSPRSTLSIVINILCGPMVSVVGSEVLVDWAKHAYITKFNRIRPQIYDKFYYIIYKDYSTRTHKLEDRLGLPLPAFVVLFIVMVRPTLFKSSEPSYLPSLFRILFMGASVFLLALLAKFTLDLILIKWSKRIEQRFRDQAFNTVVTEEEYVPGLLSGGMGKVDVSTRIALHSDYNKENRIETESVSPMRKRKTTLTAECTPPSLNDIRRQKDSKNPRSLENVARYKMVSKRIW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationKRLLRRNSAPSAIHI
HHHHHHCCCCCHHHH		39.4817330950
180PhosphorylationYHRIKRQSTMKLYML
HHHHHHHHHHHHHHH		34.2128889911
181PhosphorylationHRIKRQSTMKLYMLF
HHHHHHHHHHHHHHH		15.2428889911
185PhosphorylationRQSTMKLYMLFSVLE
HHHHHHHHHHHHHHH		6.0527017623
189PhosphorylationMKLYMLFSVLEMADK
HHHHHHHHHHHHHHH		23.1028889911
200PhosphorylationMADKMLASLGQSLLT
HHHHHHHHHHHHHHH		29.1319779198
211PhosphorylationSLLTVMLSRKNSERI
HHHHHHHHCCCCHHH		24.1027017623
314PhosphorylationRNLQSWSSSLSNTSI
CCHHHHHHHCCCCEE		29.1024930733
317PhosphorylationQSWSSSLSNTSINFW
HHHHHHCCCCEECCC		39.7524930733
318N-linked_GlycosylationSWSSSLSNTSINFWS
HHHHHCCCCEECCCC		43.04-
325PhosphorylationNTSINFWSPRSTLSI
CCEECCCCCCHHHHH		13.2924930733
432PhosphorylationRILFMGASVFLLALL
HHHHHHHHHHHHHHH		13.9927017623
509PhosphorylationRIETESVSPMRKRKT
CCCCCCCCCCCCCCC		23.4321440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAPT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAPT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAPT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRE5_YEASTBRE5genetic
19325107
CUE1_YEASTCUE1genetic
19325107
ERV14_YEASTERV14genetic
19325107
GLO3_YEASTGLO3genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
PER1_YEASTPER1genetic
19325107
SC61A_YEASTSEC61genetic
19325107
SEC62_YEASTSEC62genetic
19325107
SEC66_YEASTSEC66genetic
19325107
UBC7_YEASTUBC7genetic
19325107
UBX2_YEASTUBX2genetic
19325107
VPS9_YEASTVPS9genetic
19325107
ARP6_YEASTARP6genetic
19325107
GGPPS_YEASTBTS1genetic
19325107
CALX_YEASTCNE1genetic
19325107
EDE1_YEASTEDE1genetic
19325107
FAT1_YEASTFAT1genetic
19325107
GCR2_YEASTGCR2genetic
19325107
TRS85_YEASTTRS85genetic
19325107
GTR1_YEASTGTR1genetic
19325107
H2AZ_YEASTHTZ1genetic
19325107
KRE1_YEASTKRE1genetic
19325107
MDY2_YEASTMDY2genetic
19325107
MNN2_YEASTMNN2genetic
19325107
NEM1_YEASTNEM1genetic
19325107
OST5_YEASTOST5genetic
19325107
SAC7_YEASTSAC7genetic
19325107
SIL1_YEASTSIL1genetic
19325107
SPC1_YEASTSPC1genetic
19325107
SUM1_YEASTSUM1genetic
19325107
SWC5_YEASTSWC5genetic
19325107
VPS52_YEASTVPS52genetic
19325107
VPS71_YEASTVPS71genetic
19325107
VPS72_YEASTVPS72genetic
19325107
YHN8_YEASTYHR078Wgenetic
19325107
GET4_YEASTGET4genetic
19325107
SWC3_YEASTSWC3genetic
19325107
SLP1_YEASTSLP1genetic
19325107
SLP1_YEASTSLP1physical
23275891
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAPT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.

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