| UniProt ID | SWC3_YEAST | |
|---|---|---|
| UniProt AC | P31376 | |
| Protein Name | SWR1-complex protein 3 | |
| Gene Name | SWC3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 625 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.. | |
| Protein Sequence | MPAVLRTRSKESSIEQKPASRTRTRSRRGKRGRDDDDDDDDEESDDAYDEVGNDYDEYASRAKLATNRPFEIVAGLPASVELPNYNSSLTHPQSIKNSGVLYDSLVSSRRTWVQGEMFELYWRRPKKIVSESTPAATESPTSGTIPLIRDKMQKMCDCVMSGGPHTFKVRLFILKNDKIEQKWQDEQELKKKEKELKRKNDAEAKRLRMEERKRQQMQKKIAKEQKLQLQKENKAKQKLEQEALKLKRKEEMKKLKEQNKNKQGSPSSSMHDPRMIMNLNLMAQEDPKLNTLMETVAKGLANNSQLEEFKKFIEIAKKRSLEENPVNKRPSVTTTRPAPPSKAKDVAEDHRLNSITLVKSSKTAATEPEPKKADDENAEKQQSKEAKTTAESTQVDVKKEEEDVKEKGVKSEDTQKKEDNQVVPKRKRRKNAIKEDKDMQLTAFQQKYVQGAEIILEYLEFTHSRYYLPKKSVVEFLEDTDEIIISWIVIHNSKEIEKFKTKKIKAKLKADQKLNKEDAKPGSDVEKEVSFNPLFEADCPTPLYTPMTMKLSGIHKRFNQIIRNSVSPMEEVVKEMEKILQIGTRLSGYNLWYQLDGYDDEALSESLRFELNEWEHAMRSRRHKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | PAVLRTRSKESSIEQ CCCCCCCCCCCCCCC | 39.91 | 30377154 | |
| 10 | Acetylation | AVLRTRSKESSIEQK CCCCCCCCCCCCCCC | 59.32 | 25381059 | |
| 12 | Phosphorylation | LRTRSKESSIEQKPA CCCCCCCCCCCCCCC | 40.11 | 29136822 | |
| 13 | Phosphorylation | RTRSKESSIEQKPAS CCCCCCCCCCCCCCC | 31.10 | 29136822 | |
| 44 | Phosphorylation | DDDDDEESDDAYDEV CCCCCCCCCHHHHHH | 38.45 | 29136822 | |
| 48 | Phosphorylation | DEESDDAYDEVGNDY CCCCCHHHHHHCCCH | 21.45 | 29136822 | |
| 130 | Phosphorylation | RRPKKIVSESTPAAT CCCCCCCCCCCCCCC | 29.33 | 29688323 | |
| 132 | Phosphorylation | PKKIVSESTPAATES CCCCCCCCCCCCCCC | 31.98 | 29688323 | |
| 137 | Phosphorylation | SESTPAATESPTSGT CCCCCCCCCCCCCCC | 38.82 | 24961812 | |
| 139 | Phosphorylation | STPAATESPTSGTIP CCCCCCCCCCCCCCC | 29.17 | 25752575 | |
| 141 | Phosphorylation | PAATESPTSGTIPLI CCCCCCCCCCCCCHH | 49.41 | 24961812 | |
| 142 | Phosphorylation | AATESPTSGTIPLIR CCCCCCCCCCCCHHH | 37.01 | 27214570 | |
| 144 | Phosphorylation | TESPTSGTIPLIRDK CCCCCCCCCCHHHHH | 21.13 | 24961812 | |
| 166 | Phosphorylation | VMSGGPHTFKVRLFI HHCCCCCEEEEEEEE | 28.43 | 27017623 | |
| 265 | Phosphorylation | QNKNKQGSPSSSMHD HHCCCCCCCCHHCCC | 21.08 | 25752575 | |
| 268 | Phosphorylation | NKQGSPSSSMHDPRM CCCCCCCHHCCCHHH | 34.76 | 17563356 | |
| 269 | Phosphorylation | KQGSPSSSMHDPRMI CCCCCCHHCCCHHHH | 25.19 | 23749301 | |
| 331 | Phosphorylation | NPVNKRPSVTTTRPA CCCCCCCCCCCCCCC | 35.81 | 28889911 | |
| 335 | Phosphorylation | KRPSVTTTRPAPPSK CCCCCCCCCCCCCCH | 25.86 | 21440633 | |
| 341 | Phosphorylation | TTRPAPPSKAKDVAE CCCCCCCCHHHCHHH | 44.16 | 21440633 | |
| 354 | Phosphorylation | AEDHRLNSITLVKSS HHHHCCCEEEEEECC | 22.88 | 30377154 | |
| 360 | Phosphorylation | NSITLVKSSKTAATE CEEEEEECCCCCCCC | 29.59 | 30377154 | |
| 361 | Phosphorylation | SITLVKSSKTAATEP EEEEEECCCCCCCCC | 28.45 | 30377154 | |
| 366 | Phosphorylation | KSSKTAATEPEPKKA ECCCCCCCCCCCCCC | 50.00 | 25704821 | |
| 523 | Phosphorylation | KEDAKPGSDVEKEVS HHHCCCCCCCCCCCC | 47.19 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SWC3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SWC3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SWC3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-142 ANDSER-523, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASSSPECTROMETRY. | |
