| UniProt ID | RCO1_YEAST | |
|---|---|---|
| UniProt AC | Q04779 | |
| Protein Name | Transcriptional regulatory protein RCO1 | |
| Gene Name | RCO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 684 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events.. | |
| Protein Sequence | MDTSKKDTTRSPSHSNSSSPSSSSLSSSSSKEKKRPKRLSSQNVNYDLKRRKIITSEGIERSFKNEHSNLAVEDNIPEEEPKELLEKDSKGNIIKLNEPSTISEDSKVSVTGLPLNKGPSEKIKRESLWNYRKNLGGQSNNSEMTLVPSKRFTQVPKNFQDLNRNDLKTFLTENMTEESNIRSTIGWNGDIINRTRDREPESDRDNKKLSNIRTKIILSTNATYDSKSKLFGQNSIKSTSNASEKIFRDKNNSTIDFENEDFCSACNQSGSFLCCDTCPKSFHFLCLDPPIDPNNLPKGDWHCNECKFKIFINNSMATLKKIESNFIKQNNNVKIFAKLLFNIDSHNPKQFQLPNYIKETFPAVKTGSRGQYSDENDKIPLTDRQLFNTSYGQSITKLDSYNPDTHIDSNSGKFLICYKCNQTRLGSWSHPENSRLIMTCDYCQTPWHLDCVPRASFKNLGSKWKCPLHSPTKVYKKIHHCQEDNSVNYKVWKKQRLINKKNQLYYEPLQKIGYQNNGNIQIIPTTSHTDYDFNQDFKITQIDENSIKYDFFDKIYKSKMVQKRKLFQFQESLIDKLVSNGSQNGNSEDNMVKDIASLIYFQVSNNDKSSNNKSASKSNNLRKLWDLKELTNVVVPNELDSIQFNDFSSDEIKHLLYLKKIIESKPKEELLKFLNIENPENQSE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDTSKKDT -------CCCCCCCC | 13.15 | 22814378 | |
| 8 | Phosphorylation | MDTSKKDTTRSPSHS CCCCCCCCCCCCCCC | 32.75 | 21440633 | |
| 9 | Phosphorylation | DTSKKDTTRSPSHSN CCCCCCCCCCCCCCC | 39.00 | 19779198 | |
| 11 | Phosphorylation | SKKDTTRSPSHSNSS CCCCCCCCCCCCCCC | 28.76 | 20377248 | |
| 13 | Phosphorylation | KDTTRSPSHSNSSSP CCCCCCCCCCCCCCC | 40.57 | 20377248 | |
| 15 | Phosphorylation | TTRSPSHSNSSSPSS CCCCCCCCCCCCCCC | 42.62 | 21551504 | |
| 17 | Phosphorylation | RSPSHSNSSSPSSSS CCCCCCCCCCCCCCC | 34.90 | 20377248 | |
| 18 | Phosphorylation | SPSHSNSSSPSSSSL CCCCCCCCCCCCCCC | 50.98 | 21440633 | |
| 19 | Phosphorylation | PSHSNSSSPSSSSLS CCCCCCCCCCCCCCC | 28.73 | 20377248 | |
| 21 | Phosphorylation | HSNSSSPSSSSLSSS CCCCCCCCCCCCCCC | 44.81 | 19823750 | |
| 22 | Phosphorylation | SNSSSPSSSSLSSSS CCCCCCCCCCCCCCC | 27.59 | 19823750 | |
| 23 | Phosphorylation | NSSSPSSSSLSSSSS CCCCCCCCCCCCCCC | 39.37 | 21440633 | |
| 24 | Phosphorylation | SSSPSSSSLSSSSSK CCCCCCCCCCCCCCC | 33.93 | 19823750 | |
| 26 | Phosphorylation | SPSSSSLSSSSSKEK CCCCCCCCCCCCCCC | 30.07 | 19823750 | |
| 27 | Phosphorylation | PSSSSLSSSSSKEKK CCCCCCCCCCCCCCC | 39.26 | 19823750 | |
| 28 | Phosphorylation | SSSSLSSSSSKEKKR CCCCCCCCCCCCCCC | 34.94 | 19823750 | |
| 29 | Phosphorylation | SSSLSSSSSKEKKRP CCCCCCCCCCCCCCC | 47.58 | 19823750 | |
| 30 | Phosphorylation | SSLSSSSSKEKKRPK CCCCCCCCCCCCCCC | 46.94 | 28889911 | |
| 40 | Phosphorylation | KKRPKRLSSQNVNYD CCCCCCCCCCCCCHH | 33.63 | 21440633 | |
| 41 | Phosphorylation | KRPKRLSSQNVNYDL CCCCCCCCCCCCHHH | 30.30 | 21440633 | |
| 46 | Phosphorylation | LSSQNVNYDLKRRKI CCCCCCCHHHHHCCE | 20.54 | 27017623 | |
| 49 | Acetylation | QNVNYDLKRRKIITS CCCCHHHHHCCEECC | 47.46 | 24489116 | |
| 62 | Phosphorylation | TSEGIERSFKNEHSN CCHHHHHHHCCCCCC | 27.99 | 21440633 | |
| 64 | Acetylation | EGIERSFKNEHSNLA HHHHHHHCCCCCCCC | 63.77 | 24489116 | |
| 68 | Phosphorylation | RSFKNEHSNLAVEDN HHHCCCCCCCCCCCC | 27.62 | 25521595 | |
| 87 | Acetylation | EPKELLEKDSKGNII CCHHHHHCCCCCCEE | 68.24 | 24489116 | |
| 95 | Acetylation | DSKGNIIKLNEPSTI CCCCCEEEECCCCCC | 41.27 | 24489116 | |
| 103 | Phosphorylation | LNEPSTISEDSKVSV ECCCCCCCCCCCEEE | 35.12 | 30377154 | |
| 106 | Phosphorylation | PSTISEDSKVSVTGL CCCCCCCCCEEEECC | 30.79 | 30377154 | |
| 157 | Acetylation | KRFTQVPKNFQDLNR CCCCCCCCCHHHCCH | 72.10 | 24489116 | |
| 214 | Phosphorylation | KKLSNIRTKIILSTN HHHHHHCEEEEEECC | 23.85 | 21126336 | |
| 227 | Acetylation | TNATYDSKSKLFGQN CCCCCCCCCHHCCCC | 49.03 | 24489116 | |
| 235 | Phosphorylation | SKLFGQNSIKSTSNA CHHCCCCCCCCCCCH | 24.41 | 30377154 | |
| 245 | Acetylation | STSNASEKIFRDKNN CCCCHHHHHHCCCCC | 44.65 | 24489116 | |
| 253 | Phosphorylation | IFRDKNNSTIDFENE HHCCCCCCEEECCCH | 35.81 | 27214570 | |
| 368 | Phosphorylation | FPAVKTGSRGQYSDE CCCCCCCCCCCCCCC | 38.17 | 28889911 | |
| 373 | Phosphorylation | TGSRGQYSDENDKIP CCCCCCCCCCCCCCC | 30.47 | 23749301 | |
| 378 | Acetylation | QYSDENDKIPLTDRQ CCCCCCCCCCCCHHH | 58.78 | 24489116 | |
| 390 | Phosphorylation | DRQLFNTSYGQSITK HHHHHCCCCCCCEEE | 28.50 | 30377154 | |
| 394 | Phosphorylation | FNTSYGQSITKLDSY HCCCCCCCEEECCCC | 28.06 | 22369663 | |
| 396 | Phosphorylation | TSYGQSITKLDSYNP CCCCCCEEECCCCCC | 30.70 | 22369663 | |
| 397 | Acetylation | SYGQSITKLDSYNPD CCCCCEEECCCCCCC | 48.94 | 24489116 | |
| 400 | Phosphorylation | QSITKLDSYNPDTHI CCEEECCCCCCCCCC | 36.93 | 30377154 | |
| 470 | Phosphorylation | KWKCPLHSPTKVYKK CCCCCCCCCCCHHHH | 41.78 | 21440633 | |
| 472 | Phosphorylation | KCPLHSPTKVYKKIH CCCCCCCCCHHHHHH | 35.84 | 28889911 | |
| 506 | Phosphorylation | NKKNQLYYEPLQKIG CCCCCEEECCHHHHC | 21.47 | 29734811 | |
| 511 | Acetylation | LYYEPLQKIGYQNNG EEECCHHHHCCCCCC | 45.86 | 24489116 | |
| 546 | Phosphorylation | ITQIDENSIKYDFFD EEEECCCCCCHHHHH | 20.57 | 28889911 | |
| 657 | Phosphorylation | DEIKHLLYLKKIIES HHHHHHHHHHHHHHC | 23.88 | 27017623 | |
| 664 | Phosphorylation | YLKKIIESKPKEELL HHHHHHHCCCHHHHH | 43.80 | 27017623 | |
| 683 | Phosphorylation | IENPENQSE------ CCCCCCCCC------ | 57.78 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RCO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RCO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RCO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; SER-368; SER-394 ANDSER-683, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683, AND MASSSPECTROMETRY. | |
