SGO1_YEAST - dbPTM
SGO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SGO1_YEAST
UniProt AC Q08490
Protein Name Shugoshin
Gene Name SGO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 590
Subcellular Localization Chromosome, centromere . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Localizes to the centromere during S and M phases, dissociates at the onset of anaphase. Colocalizes with kinetochores. Associates with the spindle
Protein Description Plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Probably act by protecting REC8 and RAD21 from separase degradation during anaphase. Also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension..
Protein Sequence MPKRKIAPNKESSRRTVSHDDLTPQIQEFQNLMDLESQKVENIRQSYSRQNSLLAKDNSILKIKVNSLEKKISQLVQENVTLRSKTSISEAIYRERLSNQLQVIENGIIQRFDEIFYMFENVRKNENLPSSSLRTMLKRTSSRSRSCSLSSPTYSKSYTRLSNHENNLSHESSFNKDDGPDLEPKAKKRKSSRRQSMFVSTSLEPEDETGENEPMMENSSVEVPAESHESAQVEETIDALNPEEENSDSVSNFTNSIIEYSIPEENPTEPEHSSSKLEIFNDSTNMLSTVPSNPLPLPLPGPSATLPTTTSDASTVYPSSSSSTNSHPKTKIKHSMKPPRIELKKKVIDEVMPVSNMSSNSEISFTRTRRTRGKAVDYTLPSLRAKMRRPSEKLVDATTVIDIHDLQVSKRNRETSHKRKSLSQDSIPDEPQLREVVVSKDYGTPKGKKTEDEIHEDTAHLMTTSNNNSNNKNEKKLTSNNSPKKSSPLLDITNKSENKKKSTRTKKLFKNAIVNNLSDENSTTRPSKSSKGTSNNNNNYNNFDNNNSNINNVNNKSVSFRLNEDDLAVFDLFGNGKAVKHQPKTYRTKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
67PhosphorylationILKIKVNSLEKKISQ
EEEEEHHHHHHHHHH		40.6721440633
144PhosphorylationLKRTSSRSRSCSLSS
HHHHCCCCCCCCCCC		30.4121440633
146PhosphorylationRTSSRSRSCSLSSPT
HHCCCCCCCCCCCCC		14.8721440633
148PhosphorylationSSRSRSCSLSSPTYS
CCCCCCCCCCCCCCC		32.3123749301
151PhosphorylationSRSCSLSSPTYSKSY
CCCCCCCCCCCCCHH		26.9323749301
162PhosphorylationSKSYTRLSNHENNLS
CCHHHHCCCCCCCCC		32.6121440633
355PhosphorylationIDEVMPVSNMSSNSE
HHHHCCCCCCCCCCE		22.4219823750
358PhosphorylationVMPVSNMSSNSEISF
HCCCCCCCCCCEEEE		30.5319823750
359PhosphorylationMPVSNMSSNSEISFT
CCCCCCCCCCEEEEE		33.3419823750
361PhosphorylationVSNMSSNSEISFTRT
CCCCCCCCEEEEEEC		37.9519823750
364PhosphorylationMSSNSEISFTRTRRT
CCCCCEEEEEECCCC		19.2619823750
366PhosphorylationSNSEISFTRTRRTRG
CCCEEEEEECCCCCC		25.0819823750
368PhosphorylationSEISFTRTRRTRGKA
CEEEEEECCCCCCCC		22.8019823750
371PhosphorylationSFTRTRRTRGKAVDY
EEEECCCCCCCCCCC		40.2519823750
416PhosphorylationSKRNRETSHKRKSLS
HHCCCCCCCCCCCCC		23.4328889911
421PhosphorylationETSHKRKSLSQDSIP
CCCCCCCCCCCCCCC		36.9721440633
423PhosphorylationSHKRKSLSQDSIPDE
CCCCCCCCCCCCCCC		38.7527214570
478PhosphorylationNKNEKKLTSNNSPKK
CCCCCCCCCCCCCCC		37.9819823750
479PhosphorylationKNEKKLTSNNSPKKS
CCCCCCCCCCCCCCC		44.4419823750
482PhosphorylationKKLTSNNSPKKSSPL
CCCCCCCCCCCCCCC		42.2027214570
487PhosphorylationNNSPKKSSPLLDITN
CCCCCCCCCCCCCCC		28.5727214570
493PhosphorylationSSPLLDITNKSENKK
CCCCCCCCCCCCCCC		35.9421440633
496PhosphorylationLLDITNKSENKKKST
CCCCCCCCCCCCCCH		48.7721440633
523PhosphorylationNLSDENSTTRPSKSS
CCCCCCCCCCCCCCC		38.1027017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SGO1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SGO1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SGO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAD2_YEASTMAD2genetic
15062096
BUB1_YEASTBUB1genetic
15062096
2A5D_YEASTRTS1physical
16541024
2AAA_YEASTTPD3physical
16541024
PP2A1_YEASTPPH21physical
16541024
PP2A2_YEASTPPH22physical
16541024
UME6_YEASTUME6genetic
17314980
PSA3_YEASTPRE9genetic
17314980
SAP30_YEASTSAP30genetic
17314980
SWD3_YEASTSWD3genetic
17314980
CIK1_YEASTCIK1genetic
17314980
GET1_YEASTGET1genetic
17314980
CCS1_YEASTCCS1genetic
17314980
RPN10_YEASTRPN10genetic
17314980
SRC1_YEASTSRC1genetic
17314980
SIN3_YEASTSIN3genetic
17314980
BRE2_YEASTBRE2genetic
17314980
SODC_YEASTSOD1genetic
17314980
CTF8_YEASTCTF8genetic
17314980
CSF1_YEASTCSF1genetic
17314980
PHO23_YEASTPHO23genetic
17314980
BUG1_YEASTBUG1genetic
17314980
SWI4_YEASTSWI4genetic
17314980
UBP12_YEASTUBP12genetic
17314980
ERG6_YEASTERG6genetic
17314980
MON2_YEASTMON2genetic
17314980
SEC66_YEASTSEC66genetic
17314980
UBP8_YEASTUBP8genetic
17314980
RT102_YEASTRTT102genetic
17314980
SDC1_YEASTSDC1genetic
17314980
GCN1_YEASTGCN1genetic
17314980
MNN10_YEASTMNN10genetic
17314980
TBA3_YEASTTUB3genetic
17314980
ITC1_YEASTITC1genetic
17314980
SPT2_YEASTSPT2genetic
17314980
MAD2_YEASTMAD2genetic
17314980
IES2_YEASTIES2genetic
17314980
ERG5_YEASTERG5genetic
17314980
RAD59_YEASTRAD59genetic
17314980
MED16_YEASTSIN4genetic
17314980
DEP1_YEASTDEP1genetic
17314980
SWI3_YEASTSWI3genetic
17314980
PBP4_YEASTPBP4genetic
17314980
MTU1_YEASTSLM3genetic
17314980
HTL1_YEASTHTL1genetic
17314980
IRA2_YEASTIRA2genetic
17314980
RAD26_YEASTRAD26genetic
17314980
OAF1_YEASTOAF1genetic
17314980
PFD2_YEASTGIM4genetic
17314980
MUB1_YEASTMUB1genetic
17314980
UBR1_YEASTUBR1genetic
17314980
COPE_YEASTSEC28genetic
17314980
CWC26_YEASTBUD13genetic
17314980
PFD3_YEASTPAC10genetic
17314980
SWC5_YEASTSWC5genetic
17314980
PFD4_YEASTGIM3genetic
17314980
MDM35_YEASTMDM35genetic
17314980
SWR1_YEASTSWR1genetic
17314980
RV161_YEASTRVS161genetic
17314980
H2AZ_YEASTHTZ1genetic
17314980
LRP1_YEASTLRP1genetic
17314980
ESP1_YEASTESP1genetic
19299562
2A5D_YEASTRTS1genetic
19299562
2ABA_YEASTCDC55genetic
19299562
SCC1_YEASTMCD1genetic
19299562
MAD1_YEASTMAD1genetic
19299562
CGS5_YEASTCLB5genetic
19581447
BIR1_YEASTBIR1genetic
21389114
SLI15_YEASTSLI15genetic
21389114
BIK1_YEASTBIK1physical
22875988
MPS3_YEASTMPS3physical
22875988
NNF1_YEASTNNF1physical
22875988
2A5D_YEASTRTS1genetic
24945276
2ABA_YEASTCDC55genetic
24945276
SMC2_YEASTSMC2physical
24945276
SLI15_YEASTSLI15genetic
24945276
SLI15_YEASTSLI15genetic
23604256
2A5D_YEASTRTS1physical
25236599
2A5D_YEASTRTS1genetic
25236599
CIK1_YEASTCIK1genetic
28040741
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SGO1_YEAST

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Related Literatures of Post-Translational Modification

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