| UniProt ID | CCS1_YEAST | |
|---|---|---|
| UniProt AC | P40202 | |
| Protein Name | Superoxide dismutase 1 copper chaperone | |
| Gene Name | CCS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 249 | |
| Subcellular Localization | Cytoplasm. Mitochondrion intermembrane space . A small percentage (around 1-5 percent) localizes to the mitochondrial intermembrane space. | |
| Protein Description | Copper chaperone for apo superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to apo-SOD1.. | |
| Protein Sequence | MTTNDTYEATYAIPMHCENCVNDIKACLKNVPGINSLNFDIEQQIMSVESSVAPSTIINTLRNCGKDAIIRGAGKPNSSAVAILETFQKYTIDQKKDTAVRGLARIVQVGENKTLFDITVNGVPEAGNYHASIHEKGDVSKGVESTGKVWHKFDEPIECFNESDLGKNLYSGKTFLSAPLPTWQLIGRSFVISKSLNHPENEPSSVKDYSFLGVIARSAGVWENNKQVCACTGKTVWEERKDALANNIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 66 | Acetylation | NTLRNCGKDAIIRGA HHHHHCCCCHHHCCC | 46.30 | 25381059 | |
| 66 | Ubiquitination | NTLRNCGKDAIIRGA HHHHHCCCCHHHCCC | 46.30 | 23749301 | |
| 75 | Ubiquitination | AIIRGAGKPNSSAVA HHHCCCCCCCHHHHH | 40.26 | 24961812 | |
| 78 | Phosphorylation | RGAGKPNSSAVAILE CCCCCCCHHHHHHHH | 28.35 | 22369663 | |
| 79 | Phosphorylation | GAGKPNSSAVAILET CCCCCCHHHHHHHHH | 33.14 | 22369663 | |
| 95 | 2-Hydroxyisobutyrylation | QKYTIDQKKDTAVRG HHCCCCCCHHHHHHH | 49.20 | - | |
| 136 | Acetylation | YHASIHEKGDVSKGV CEEEEECCCCCCCCC | 46.37 | 24489116 | |
| 141 | Ubiquitination | HEKGDVSKGVESTGK ECCCCCCCCCCCCCC | 67.82 | 23749301 | |
| 152 | Acetylation | STGKVWHKFDEPIEC CCCCEEEECCCCEEC | 38.51 | 24489116 | |
| 167 | Acetylation | FNESDLGKNLYSGKT CCHHHCCCCCCCCCC | 51.59 | 24489116 | |
| 167 | Ubiquitination | FNESDLGKNLYSGKT CCHHHCCCCCCCCCC | 51.59 | 23749301 | |
| 195 | Phosphorylation | RSFVISKSLNHPENE CEEECCCCCCCCCCC | 27.84 | 22369663 | |
| 204 | Phosphorylation | NHPENEPSSVKDYSF CCCCCCCCCCCCHHH | 41.40 | 20377248 | |
| 205 | Phosphorylation | HPENEPSSVKDYSFL CCCCCCCCCCCHHHH | 43.85 | 22369663 | |
| 207 | Acetylation | ENEPSSVKDYSFLGV CCCCCCCCCHHHHHH | 53.55 | 24489116 | |
| 207 | Ubiquitination | ENEPSSVKDYSFLGV CCCCCCCCCHHHHHH | 53.55 | 24961812 | |
| 226 | Ubiquitination | AGVWENNKQVCACTG CCCEECCEEEEECCC | 56.54 | 23749301 | |
| 234 | Acetylation | QVCACTGKTVWEERK EEEECCCCHHHHHHH | 23.04 | 25381059 | |
| 241 | Ubiquitination | KTVWEERKDALANNI CHHHHHHHHHHHHHC | 51.11 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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