BUR2_YEAST - dbPTM
BUR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BUR2_YEAST
UniProt AC Q05949
Protein Name Protein BUR2
Gene Name BUR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 395
Subcellular Localization Nucleus .
Protein Description Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 'Lys-4' trimethylation. May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. Also required for vegetative growth itself. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation..
Protein Sequence MSATSSSGDVKKFQAVPKPTSNASPPPASSGFNARTLWPDLIETPENQWVFECKDIIEKIGTNGPIAVEIKKNMEKCLMYFYTLKKKLNLFDHTYTASCILFYRYWFIYGIPTAITECIHISQGILVTACKTMENNRPIEAYIKATCEFLMQNIPSLKSRTNIDKLKWEFRDKLVTNEKKILCLFGFDLNISNPKELIEEVFSGYYRFNRDHNLPENFKKAFPKILQESRNFMVQAVTQPVSLLCDGYTFIVLSLIYCGLEYKKLVDKDFRYPKNFFKDRFPIEVTPENFANIFTDYKLLEENFFNLKSNKGAKLQIDSSMIDSVIDESGDVENEVSEISDPFNYELIKSGEVKEEFLNHIETRVKDLLDKAKQESMKRKAKDPIRTPDAKKPKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSATSSSGD
------CCCCCCCCC		40.0130377154
5Phosphorylation---MSATSSSGDVKK
---CCCCCCCCCCCC		23.4030377154
7Phosphorylation-MSATSSSGDVKKFQ
-CCCCCCCCCCCCEE		38.4930377154
20PhosphorylationFQAVPKPTSNASPPP
EECCCCCCCCCCCCC		40.5129136822
21PhosphorylationQAVPKPTSNASPPPA
ECCCCCCCCCCCCCC		38.6421440633
24PhosphorylationPKPTSNASPPPASSG
CCCCCCCCCCCCCCC		42.0421082442
29PhosphorylationNASPPPASSGFNART
CCCCCCCCCCCCCCC		36.4521440633
354AcetylationLIKSGEVKEEFLNHI
HHHCCCCHHHHHHHH		47.4224489116
387PhosphorylationKAKDPIRTPDAKKPK
HHCCCCCCCCCCCCC		26.6623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BUR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BUR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BUR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BUR1_YEASTSGV1physical
10982824
BUR1_YEASTSGV1physical
12215532
BUR1_YEASTSGV1genetic
10982824
CAK1_YEASTCAK1genetic
12215532
BUR1_YEASTSGV1genetic
16040246
TFS2_YEASTDST1genetic
16040246
SPT4_YEASTSPT4genetic
16040246
ELP1_YEASTIKI3genetic
16040246
ELP2_YEASTELP2genetic
16040246
ELP3_YEASTELP3genetic
16040246
ELP4_YEASTELP4genetic
16040246
ELP6_YEASTELP6genetic
16040246
RPN4_YEASTRPN4genetic
16040246
RPN10_YEASTRPN10genetic
16040246
PSA3_YEASTPRE9genetic
16040246
SEM1_YEASTSEM1genetic
16040246
UBP6_YEASTUBP6genetic
16040246
RIM1_YEASTRIM1physical
16554755
BUR1_YEASTSGV1physical
16554755
BUR1_YEASTSGV1physical
16429126
NOT2_YEASTCDC36genetic
17392337
NOT4_YEASTMOT2genetic
17392337
CCR4_YEASTCCR4genetic
17392337
SET2_YEASTSET2genetic
17948059
PAF1_YEASTPAF1genetic
17948059
CTR9_YEASTCTR9genetic
17948059
CDC73_YEASTCDC73genetic
17948059
LEO1_YEASTLEO1genetic
17948059
RTF1_YEASTRTF1genetic
17948059
BUR1_YEASTSGV1physical
20826334
CTK2_YEASTCTK2genetic
21283673
CTK3_YEASTCTK3genetic
21283673
SPT4_YEASTSPT4genetic
21283673
TFS2_YEASTDST1genetic
21283673
LEO1_YEASTLEO1genetic
21283673
RFA1_YEASTRFA1physical
21075850
RAD52_YEASTRAD52physical
21075850
BUR1_YEASTSGV1physical
21075850
RFA2_YEASTRFA2physical
21075850
BUR1_YEASTSGV1genetic
22022426
SET2_YEASTSET2genetic
22022426
RCO1_YEASTRCO1genetic
22022426
SET2_YEASTSET2genetic
22157004
RCO1_YEASTRCO1genetic
22157004
RNH1_YEASTRNH1genetic
22195970
RNH2A_YEASTRNH201genetic
22195970
SRO7_YEASTSRO7genetic
27708008
FMP46_YEASTFMP46genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BUR2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY.

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