PPOX_YEAST - dbPTM
PPOX_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPOX_YEAST
UniProt AC P40012
Protein Name Protoporphyrinogen oxidase
Gene Name HEM14
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 539
Subcellular Localization Mitochondrion inner membrane . Bound to the mitochondrial inner membrane with its active site facing the cytosolic side.
Protein Description Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX..
Protein Sequence MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
61PhosphorylationSCNTRDMSGNPIMLE
EECCCCCCCCEEEEE
39.4427017623
69AcetylationGNPIMLEKGPRTLRG
CCEEEEECCCCCCCC
70.9724489116
89AcetylationVLIMDTLKDLGKEAV
EEEECCHHHHCHHHH
53.6624489116
109AcetylationKGCIADKKFLLDPSD
CCCCCCCCEEECCCC
41.6224489116
210AcetylationKIYYNELKHGSNTQA
HHHHHHHCCCCCHHH
39.4824489116
260PhosphorylationRSKLLDLSNTLKKYP
HHHHHHHHHHHHHCC
27.6927017623
262PhosphorylationKLLDLSNTLKKYPML
HHHHHHHHHHHCCCC
36.2627017623
264AcetylationLDLSNTLKKYPMLGL
HHHHHHHHHCCCCHH
48.5022865919
266PhosphorylationLSNTLKKYPMLGLAG
HHHHHHHCCCCHHCC
7.7119779198
277PhosphorylationGLAGGLETFPKIVRN
HHCCCHHHHHHHHHH
50.7219779198
414AcetylationNFKPLFDKLSTNPNA
HCHHHHHHHCCCHHH
36.6824489116
424AcetylationTNPNALNKYTKVTAM
CCHHHHHHHHHHHEE
55.9624489116
447PhosphorylationHGVPVVPSREVTINA
CCCEECCCCEEHHHH
29.4827017623
451PhosphorylationVVPSREVTINAVKDA
ECCCCEEHHHHHHHH
12.0827017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPOX_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPOX_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPOX_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PPOX_YEASTHEM14physical
22940862

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPOX_YEAST

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Related Literatures of Post-Translational Modification

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