PPOX_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPOX_YEAST
• UniProt AC: P40012
• Protein Name: Protoporphyrinogen oxidase
• Gene Name: HEM14
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 539
• Subcellular Localization: Mitochondrion inner membrane . Bound to the mitochondrial inner membrane with its active site facing the cytosolic side.
• Protein Description: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX..
• Protein Sequence: MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	SCNTRDMSGNPIMLE EECCCCCCCCEEEEE	39.44	27017623
69	Acetylation	GNPIMLEKGPRTLRG CCEEEEECCCCCCCC	70.97	24489116
89	Acetylation	VLIMDTLKDLGKEAV EEEECCHHHHCHHHH	53.66	24489116
109	Acetylation	KGCIADKKFLLDPSD CCCCCCCCEEECCCC	41.62	24489116
210	Acetylation	KIYYNELKHGSNTQA HHHHHHHCCCCCHHH	39.48	24489116
260	Phosphorylation	RSKLLDLSNTLKKYP HHHHHHHHHHHHHCC	27.69	27017623
262	Phosphorylation	KLLDLSNTLKKYPML HHHHHHHHHHHCCCC	36.26	27017623
264	Acetylation	LDLSNTLKKYPMLGL HHHHHHHHHCCCCHH	48.50	22865919
266	Phosphorylation	LSNTLKKYPMLGLAG HHHHHHHCCCCHHCC	7.71	19779198
277	Phosphorylation	GLAGGLETFPKIVRN HHCCCHHHHHHHHHH	50.72	19779198
414	Acetylation	NFKPLFDKLSTNPNA HCHHHHHHHCCCHHH	36.68	24489116
424	Acetylation	TNPNALNKYTKVTAM CCHHHHHHHHHHHEE	55.96	24489116
447	Phosphorylation	HGVPVVPSREVTINA CCCEECCCCEEHHHH	29.48	27017623
451	Phosphorylation	VVPSREVTINAVKDA ECCCCEEHHHHHHHH	12.08	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPOX_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPOX_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPOX_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPOX_YEAST	HEM14	physical	22940862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.