UniProt ID | PPOX_YEAST | |
---|---|---|
UniProt AC | P40012 | |
Protein Name | Protoporphyrinogen oxidase | |
Gene Name | HEM14 | |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
Sequence Length | 539 | |
Subcellular Localization | Mitochondrion inner membrane . Bound to the mitochondrial inner membrane with its active site facing the cytosolic side. | |
Protein Description | Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.. | |
Protein Sequence | MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
61 | Phosphorylation | SCNTRDMSGNPIMLE EECCCCCCCCEEEEE | 39.44 | 27017623 | |
69 | Acetylation | GNPIMLEKGPRTLRG CCEEEEECCCCCCCC | 70.97 | 24489116 | |
89 | Acetylation | VLIMDTLKDLGKEAV EEEECCHHHHCHHHH | 53.66 | 24489116 | |
109 | Acetylation | KGCIADKKFLLDPSD CCCCCCCCEEECCCC | 41.62 | 24489116 | |
210 | Acetylation | KIYYNELKHGSNTQA HHHHHHHCCCCCHHH | 39.48 | 24489116 | |
260 | Phosphorylation | RSKLLDLSNTLKKYP HHHHHHHHHHHHHCC | 27.69 | 27017623 | |
262 | Phosphorylation | KLLDLSNTLKKYPML HHHHHHHHHHHCCCC | 36.26 | 27017623 | |
264 | Acetylation | LDLSNTLKKYPMLGL HHHHHHHHHCCCCHH | 48.50 | 22865919 | |
266 | Phosphorylation | LSNTLKKYPMLGLAG HHHHHHHCCCCHHCC | 7.71 | 19779198 | |
277 | Phosphorylation | GLAGGLETFPKIVRN HHCCCHHHHHHHHHH | 50.72 | 19779198 | |
414 | Acetylation | NFKPLFDKLSTNPNA HCHHHHHHHCCCHHH | 36.68 | 24489116 | |
424 | Acetylation | TNPNALNKYTKVTAM CCHHHHHHHHHHHEE | 55.96 | 24489116 | |
447 | Phosphorylation | HGVPVVPSREVTINA CCCEECCCCEEHHHH | 29.48 | 27017623 | |
451 | Phosphorylation | VVPSREVTINAVKDA ECCCCEEHHHHHHHH | 12.08 | 27017623 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPOX_YEAST !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPOX_YEAST !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPOX_YEAST !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PPOX_YEAST | HEM14 | physical | 22940862 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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