| UniProt ID | CIN8_YEAST | |
|---|---|---|
| UniProt AC | P27895 | |
| Protein Name | Kinesin-like protein CIN8 | |
| Gene Name | CIN8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1000 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, spindle. Mitochondrion. Spindle microtubules that lie between the poles. | |
| Protein Description | Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediated by KAR3.. | |
| Protein Sequence | MPAENQNTGQDRSSNSISKNGNSQVGCHTVPNEELNITVAVRCRGRNEREISMKSSVVVNVPDITGSKEISINTTGDTGITAQMNAKRYTVDKVFGPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFDTLELQQNDYVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKKHQDELFRISKMNLVDLAGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVDKSGHIPFRESKLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSKEGIYMSQDHYKNLNSDLESYKNEVQECKREIESLTSKNALLVKDKLKSKETIQSQNCQIESLKTTIDHLRAQLDKQHKTEIEISDFNNKLQKLTEVMQMALHDYKKRELDLNQKFEMHITKEIKKLKSTLFLQLNTMQQESILQETNIQPNLDMIKNEVLTLMRTMQEKAELMYKDCVKKILNESPKFFNVVIEKIDIIRVDFQKFYKNIAENLSDISEENNNMKQYLKNHFFKNNHQELLNRHVDSTYENIEKRTNEFVENFKKVLNDHLDENKKLIMQNLTTATSAVIDQEMDLFEPKRVKWENSFDLINDCDSMNNEFYNSMAATLSQIKSTVDTSSNSMNESISVMKGQVEESENAISLLKNNTKFNDQFEQLINKHNMLKDNIKNSITSTHSHITNVDDIYNTIENIMKNYGNKENATKDEMIENILKEIPNLSKKMPLRLSNINSNSVQSVISPKKHAIEDENKSSENVDNEGSRKMLKIE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 65 | Phosphorylation | VVNVPDITGSKEISI EEECCCCCCCCEEEE | 42.66 | 30377154 | |
| 89 | Phosphorylation | AQMNAKRYTVDKVFG EEECCEEEEECCCCC | 15.48 | 28132839 | |
| 123 | Phosphorylation | FIKGYNCTVLVYGMT HHHCCCEEEEEEEEC | 17.15 | 30377154 | |
| 127 | Phosphorylation | YNCTVLVYGMTSTGK CCEEEEEEEECCCCC | 9.30 | 30377154 | |
| 132 | Phosphorylation | LVYGMTSTGKTYTMT EEEEECCCCCEEEEC | 33.27 | 30377154 | |
| 136 | Phosphorylation | MTSTGKTYTMTGDEK ECCCCCEEEECCCCE | 9.67 | 30377154 | |
| 194 | Phosphorylation | ELKDLLDSNSNGSSN HHHHHHHCCCCCCCC | 41.97 | 27017623 | |
| 196 | Phosphorylation | KDLLDSNSNGSSNTG HHHHHCCCCCCCCCC | 46.66 | 27017623 | |
| 225 | Phosphorylation | STANNTTSNSASSSR CCCCCCCCCCCCCCC | 27.09 | 27017623 | |
| 227 | Phosphorylation | ANNTTSNSASSSRSN CCCCCCCCCCCCCCC | 29.33 | 23749301 | |
| 229 | Phosphorylation | NTTSNSASSSRSNSR CCCCCCCCCCCCCCC | 28.77 | 21440633 | |
| 230 | Phosphorylation | TTSNSASSSRSNSRN CCCCCCCCCCCCCCC | 29.50 | 27017623 | |
| 231 | Phosphorylation | TSNSASSSRSNSRNS CCCCCCCCCCCCCCC | 36.91 | 21440633 | |
| 247 | Phosphorylation | PRSLNDLTPKAALLR CCCHHHCCHHHHHHH | 26.13 | 27214570 | |
| 259 | Phosphorylation | LLRKRLRTKSLPNTI HHHHHHHHCCCCHHH | 29.58 | 30377154 | |
| 261 | Phosphorylation | RKRLRTKSLPNTIKQ HHHHHHCCCCHHHHH | 48.74 | 25521595 | |
| 282 | Phosphorylation | AVNSRNNSSSNSGST HHHCCCCCCCCCCCC | 38.40 | 29136822 | |
| 283 | Phosphorylation | VNSRNNSSSNSGSTT HHCCCCCCCCCCCCC | 35.34 | 29136822 | |
| 284 | Phosphorylation | NSRNNSSSNSGSTTN HCCCCCCCCCCCCCC | 34.53 | 29136822 | |
| 286 | Phosphorylation | RNNSSSNSGSTTNNA CCCCCCCCCCCCCCC | 35.75 | 29136822 | |
| 288 | Phosphorylation | NSSSNSGSTTNNASS CCCCCCCCCCCCCCC | 31.70 | 29136822 | |
| 289 | Phosphorylation | SSSNSGSTTNNASSN CCCCCCCCCCCCCCC | 36.75 | 29136822 | |
| 290 | Phosphorylation | SSNSGSTTNNASSNT CCCCCCCCCCCCCCC | 28.33 | 29136822 | |
| 294 | Phosphorylation | GSTTNNASSNTNTNN CCCCCCCCCCCCCCC | 26.67 | 29136822 | |
| 295 | Phosphorylation | STTNNASSNTNTNNG CCCCCCCCCCCCCCC | 45.31 | 29136822 | |
| 297 | Phosphorylation | TNNASSNTNTNNGQR CCCCCCCCCCCCCCC | 45.42 | 29136822 | |
| 299 | Phosphorylation | NASSNTNTNNGQRSS CCCCCCCCCCCCCCC | 28.20 | 29136822 | |
| 519 | Phosphorylation | SKEGIYMSQDHYKNL CCCCCCCCHHHHHCC | 18.58 | 27017623 | |
| 687 | Phosphorylation | QEKAELMYKDCVKKI HHHHHHHHHHHHHHH | 19.12 | 21126336 | |
| 796 | Phosphorylation | KLIMQNLTTATSAVI HHHHHHCHHHHHHHH | 23.18 | 19823750 | |
| 797 | Phosphorylation | LIMQNLTTATSAVID HHHHHCHHHHHHHHH | 30.98 | 19823750 | |
| 799 | Phosphorylation | MQNLTTATSAVIDQE HHHCHHHHHHHHHHC | 18.35 | 19823750 | |
| 800 | Phosphorylation | QNLTTATSAVIDQEM HHCHHHHHHHHHHCC | 20.34 | 19823750 | |
| 960 | Phosphorylation | KKMPLRLSNINSNSV CCCCCCCCCCCCCCC | 29.27 | 19823750 | |
| 964 | Phosphorylation | LRLSNINSNSVQSVI CCCCCCCCCCCCCCC | 27.04 | 19823750 | |
| 966 | Phosphorylation | LSNINSNSVQSVISP CCCCCCCCCCCCCCC | 22.73 | 24961812 | |
| 969 | Phosphorylation | INSNSVQSVISPKKH CCCCCCCCCCCCCHH | 21.18 | 19823750 | |
| 972 | Phosphorylation | NSVQSVISPKKHAIE CCCCCCCCCCHHCCC | 28.63 | 19823750 | |
| 984 | Phosphorylation | AIEDENKSSENVDNE CCCCCCCCCCCCCCH | 55.24 | 28889911 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CIN8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CIN8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-972, AND MASSSPECTROMETRY. | |
