IES6_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IES6_YEAST
• UniProt AC: P32617
• Protein Name: Chromatin-remodeling complex subunit IES6
• Gene Name: IES6
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 166
• Subcellular Localization: Nucleus .
• Protein Description: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length..
• Protein Sequence: MSGSRGNSSNSSVSNNSNNNNNNDGGDERLLFLRSVGERNEIGFPSRFKSAHYKKPTRRHKSARQLISDENKRINALLTKANKAAESSTAARRLVPKATYFSVEAPPSIRPAKKYCDVTGLKGFYKSPTNNIRYHNAEIYQLIVKPMAPGVDQEYLKLRGANFVLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGSRGNSS ------CCCCCCCCC	45.54	22369663
4	Phosphorylation	----MSGSRGNSSNS ----CCCCCCCCCCC	29.70	22369663
8	Phosphorylation	MSGSRGNSSNSSVSN CCCCCCCCCCCCCCC	33.45	22369663
9	Phosphorylation	SGSRGNSSNSSVSNN CCCCCCCCCCCCCCC	44.74	22369663
11	Phosphorylation	SRGNSSNSSVSNNSN CCCCCCCCCCCCCCC	33.78	22369663
12	Phosphorylation	RGNSSNSSVSNNSNN CCCCCCCCCCCCCCC	33.54	22369663
14	Phosphorylation	NSSNSSVSNNSNNNN CCCCCCCCCCCCCCC	32.04	22369663
17	Phosphorylation	NSSVSNNSNNNNNND CCCCCCCCCCCCCCC	45.22	22369663
62	Phosphorylation	KPTRRHKSARQLISD CCCHHCHHHHHHHCC	23.66	21440633
122	Ubiquitination	YCDVTGLKGFYKSPT HCCCCCCCCCCCCCC	48.60	22817900
125	Phosphorylation	VTGLKGFYKSPTNNI CCCCCCCCCCCCCCC	21.16	27017623
126	Ubiquitination	TGLKGFYKSPTNNIR CCCCCCCCCCCCCCE	47.93	23749301
127	Phosphorylation	GLKGFYKSPTNNIRY CCCCCCCCCCCCCEE	26.10	23749301
129	Phosphorylation	KGFYKSPTNNIRYHN CCCCCCCCCCCEECC	48.24	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IES6_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IES6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IES6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUVB1_YEAST	RVB1	physical	16554755
IES5_YEAST	IES5	physical	16554755
INO80_YEAST	INO80	physical	16554755
ARP4_YEAST	ARP4	physical	16554755
IES3_YEAST	IES3	physical	16554755
ARP5_YEAST	ARP5	physical	16554755
ARP8_YEAST	ARP8	physical	16554755
RUVB2_YEAST	RVB2	physical	16554755
RAD50_YEAST	RAD50	genetic	15607974
RAD52_YEAST	RAD52	genetic	15607974
RAD54_YEAST	RAD54	genetic	15607974
RAD55_YEAST	RAD55	genetic	15607974
SRS2_YEAST	SRS2	genetic	21459050
HDA1_YEAST	HDA1	genetic	23207916
H3_YEAST	HHT1	physical	24034245
H4_YEAST	HHF1	physical	24034245
INO80_YEAST	INO80	physical	26755556
ARP8_YEAST	ARP8	physical	26755556
ARP5_YEAST	ARP5	physical	26755556
RUVB1_YEAST	RVB1	physical	26755556
RUVB2_YEAST	RVB2	physical	26755556
ARP8_YEAST	ARP8	genetic	26755556
INO80_YEAST	INO80	physical	26306040
ARP8_YEAST	ARP8	physical	26306040
IES2_YEAST	IES2	physical	26306040
ARP4_YEAST	ARP4	physical	26306040
RUVB1_YEAST	RVB1	physical	26306040
RUVB2_YEAST	RVB2	physical	26306040
ACT_YEAST	ACT1	physical	26306040
IES3_YEAST	IES3	physical	26306040
ARP5_YEAST	ARP5	physical	26306040
NHP10_YEAST	NHP10	physical	26306040

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.