MSRA_YEAST - dbPTM
MSRA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSRA_YEAST
UniProt AC P40029
Protein Name Peptide methionine sulfoxide reductase
Gene Name MXR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 184
Subcellular Localization
Protein Description Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product..
Protein Sequence MSSLISKTIKYDPAKDKLITLACGCFWGTEHMYRKYLNDRIVDCKVGYANGEESKKDSPSSVSYKRVCGGDTDFAEVLQVSYNPKVITLRELTDFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQPKWGNKIATVIEPIKNFYDAEEYHQLYLDKNPQGYACPTHYLREM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationGYANGEESKKDSPSS
CCCCCCCCCCCCCCC		40.4821440633
58PhosphorylationGEESKKDSPSSVSYK
CCCCCCCCCCCCCCE		35.2419823750
60PhosphorylationESKKDSPSSVSYKRV
CCCCCCCCCCCCEEC		47.5320377248
61PhosphorylationSKKDSPSSVSYKRVC
CCCCCCCCCCCEECC		20.6122369663
63PhosphorylationKDSPSSVSYKRVCGG
CCCCCCCCCEECCCC		27.2122369663
64PhosphorylationDSPSSVSYKRVCGGD
CCCCCCCCEECCCCC		10.7226447709
65AcetylationSPSSVSYKRVCGGDT
CCCCCCCEECCCCCC		30.7425381059
124PhosphorylationRSGLFAHSDADLKEL
CCCCCCCCCCCHHHH		30.9421440633
129AcetylationAHSDADLKELAKIKE
CCCCCCHHHHHHHHH		51.7524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSRA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSRA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSRA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YRF14_YEASTYRF1-4physical
18467557
MXR2_YEASTMXR2genetic
19049972
FRMSR_YEASTYKL069Wgenetic
19049972
TRX2_YEASTTRX2physical
21345799
MSRA_YEASTMXR1physical
21345799
ATG12_YEASTATG12genetic
27708008
HSP78_YEASTHSP78genetic
27708008
POC4_YEASTPOC4genetic
27708008
RFA1_YEASTRFA1genetic
27708008
MCM2_YEASTMCM2genetic
27708008
LSM2_YEASTLSM2genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CDS1_YEASTCDS1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
CDK1_YEASTCDC28genetic
27708008
KRR1_YEASTKRR1genetic
27708008
RPB1_YEASTRPO21genetic
27708008
CAK1_YEASTCAK1genetic
27708008
YIP1_YEASTYIP1genetic
27708008
OKP1_YEASTOKP1genetic
27708008
ORC6_YEASTORC6genetic
27708008
KTHY_YEASTCDC8genetic
27708008
TAP42_YEASTTAP42genetic
27708008
DCP2_YEASTDCP2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
SWD1_YEASTSWD1genetic
27708008
TOD6_YEASTTOD6genetic
27708008
ECM33_YEASTECM33genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
AIM4_YEASTAIM4genetic
27708008
FAT2_YEASTPCS60genetic
27708008
LHP1_YEASTLHP1genetic
27708008
AROF_YEASTARO3genetic
27708008
GIS1_YEASTGIS1genetic
27708008
SAN1_YEASTSAN1genetic
27708008
ENT5_YEASTENT5genetic
27708008
THI74_YEASTTHI74genetic
27708008
SDC1_YEASTSDC1genetic
27708008
SLF1_YEASTSLF1genetic
27708008
BLM10_YEASTBLM10genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
TFS2_YEASTDST1genetic
27708008
TOS8_YEASTTOS8genetic
27708008
MON1_YEASTMON1genetic
27708008
MED5_YEASTNUT1genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
HGH1_YEASTHGH1genetic
27708008
TRX2_YEASTTRX2genetic
27708008
KSP1_YEASTKSP1genetic
27708008
ARP1_YEASTARP1genetic
27708008
YIQ3_YEASTYIL163Cgenetic
27708008
YIW2_YEASTYIR042Cgenetic
27708008
ASF1_YEASTASF1genetic
27708008
RPE_YEASTRPE1genetic
27708008
HS150_YEASTHSP150genetic
27708008
HIR3_YEASTHIR3genetic
27708008
KAPC_YEASTTPK3genetic
27708008
PUF3_YEASTPUF3genetic
27708008
LDB18_YEASTLDB18genetic
27708008
BRE2_YEASTBRE2genetic
27708008
ROM2_YEASTROM2genetic
27708008
CDC73_YEASTCDC73genetic
27708008
NU188_YEASTNUP188genetic
27708008
SOK2_YEASTSOK2genetic
27708008
YMP8_YEASTYMR018Wgenetic
27708008
COG5_YEASTCOG5genetic
27708008
SWS2_YEASTSWS2genetic
27708008
NST1_YEASTNST1genetic
27708008
ZEO1_YEASTZEO1genetic
27708008
2A5D_YEASTRTS1genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
ALG8_YEASTALG8genetic
27708008
VAM10_YEASTVAM10genetic
27708008
DIA2_YEASTDIA2genetic
27708008
CAF20_YEASTCAF20genetic
27708008
YPK9_YEASTYPK9genetic
27708008
CIN1_YEASTCIN1genetic
27708008
VTS1_YEASTVTS1genetic
27708008
GPB1_YEASTGPB1genetic
27708008
SVL3_YEASTSVL3genetic
27708008
YP068_YEASTYPL068Cgenetic
27708008
SPP1_YEASTSPP1genetic
27708008
PTPA2_YEASTRRD2genetic
27708008
CG12_YEASTCLN2genetic
27708008
ETFA_YEASTAIM45genetic
27708008
YMC1_YEASTYMC1genetic
27708008
SPEE_YEASTSPE3genetic
27708008
CGS5_YEASTCLB5genetic
27708008
TPO3_YEASTTPO3genetic
27708008
HDA3_YEASTHDA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSRA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY.

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