YRF14_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YRF14_YEAST
• UniProt AC: O13559
• Protein Name: Y' element ATP-dependent helicase protein 1 copy 4
• Gene Name: YRF1-4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1382
• Protein Description: Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance..
• Protein Sequence: MWKTLGRVEQLLPYASLILRNREVLFREPKRGIDEYLENDSFFQMIPVKYREIVLPKLRRDTNKMTAALKNKVAVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGRKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIIALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSAITTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Ubiquitination	KLRRDTNKMTAALKN HHCCCCHHHHHHHHH	39.46	23749301
130	Ubiquitination	QLYTDYNKNGSSEPR EEECCCCCCCCCCCC	57.36	17644757
226	Ubiquitination	QYMRELPKNAPQKLN HHHHHCCCCCCCCCC	77.64	23749301
282	Phosphorylation	RNIYGVDSFSLTSVS CCEECCCCEEEEECC	17.83	27214570
289	Phosphorylation	SFSLTSVSGTTATLL CEEEEECCCCHHHHH	30.14	27214570
499	Ubiquitination	TFRTNNVKLGYLIVD EEECCCEEEEEEEEE	38.01	17644757
534	Ubiquitination	LDFDAFEKAIFLSGT CCHHHHHHHHHHCCC	40.09	17644757
591	Ubiquitination	TRMFNLIKEKSEVPL HHHHHHHHHCCCCCC	63.36	17644757
593	Ubiquitination	MFNLIKEKSEVPLGH HHHHHHHCCCCCCCH	47.08	17644757
603	Ubiquitination	VPLGHVHKIWKKVES CCCCHHHHHHHHHHC	49.53	17644757
606	Ubiquitination	GHVHKIWKKVESQPE CHHHHHHHHHHCCHH	50.87	17644757
607	Ubiquitination	HVHKIWKKVESQPEE HHHHHHHHHHCCHHH	35.92	17644757
617	Ubiquitination	SQPEEALKLLLALFE CCHHHHHHHHHHHHC	44.10	17644757
733	Phosphorylation	YLLSRKNSWAARNRK EEEECCCCHHHHCCC	22.56	27214570
767	Ubiquitination	GLESKKGKKGQHVGC CCCCCCCCCCCEECC	63.71	17644757
768	Ubiquitination	LESKKGKKGQHVGCC CCCCCCCCCCEECCC	72.91	17644757
801	Phosphorylation	RLAEKQATASMSIIA HHHHHHHHHCEEEEE	19.44	19684113
803	Phosphorylation	AEKQATASMSIIALP HHHHHHHCEEEEECC	14.54	28889911
812	Phosphorylation	SIIALPSSFQESNSS EEEECCCCCCCCCCC	29.07	28889911
816	Phosphorylation	LPSSFQESNSSDRCR CCCCCCCCCCCHHHH	31.09	19779198
818	Phosphorylation	SSFQESNSSDRCRKY CCCCCCCCCHHHHHH	42.78	19779198
819	Phosphorylation	SFQESNSSDRCRKYC CCCCCCCCHHHHHHC	33.07	19684113
859	Phosphorylation	TNATTTASTNVRTSA CCCEEECCCEECCCC	20.58	28889911
864	Phosphorylation	TASTNVRTSATTTAS ECCCEECCCCEEEEE	20.59	27017623
869	Phosphorylation	VRTSATTTASINVRT ECCCCEEEEEEEEEE	17.66	27017623
895	Phosphorylation	TNATTTASTNVRTSA CCCEEEEECCEECCE	20.58	28889911
900	Phosphorylation	TASTNVRTSATTTAS EEECCEECCEEEEEE	20.59	27017623
905	Phosphorylation	VRTSATTTASINVRT EECCEEEEEEEEEEE	17.66	27017623
975	Phosphorylation	TNSSTNATTTESTNA CCCCCCCCCCCCCCC	36.00	27017623
977	Phosphorylation	SSTNATTTESTNASA CCCCCCCCCCCCCHH	24.47	27017623
980	Phosphorylation	NATTTESTNASAKED CCCCCCCCCCHHHHH	28.68	27017623
1013	Ubiquitination	NKESYKRKGSQMVLL CHHHHHCCCCEEEEE	59.78	17644757
1015	Phosphorylation	ESYKRKGSQMVLLER HHHHCCCCEEEEEEH	20.38	25752575
1023	Ubiquitination	QMVLLERKKLKAQFP EEEEEEHHHHHHHCC	53.75	17644757
1026	Ubiquitination	LLERKKLKAQFPNTS EEEHHHHHHHCCCCC	49.36	17644757
1132	Ubiquitination	GDPVGYLKYFSVKRG CCCCCEEEEEEEECC	35.45	24961812
1137	Ubiquitination	YLKYFSVKRGEIYSQ EEEEEEEECCCHHHH	54.19	17644757
1171	Ubiquitination	VLDSTRGKQGSQVFR EECCCCCCCCCEEEE	48.47	23749301
1241	Phosphorylation	GVFQRLRSMTSAGLQ CHHHHHHHCCCCCCC	30.88	27017623
1252	Phosphorylation	AGLQGPQYVKLQFSR CCCCCCCEEEEEECH	11.59	27017623
1254	Ubiquitination	LQGPQYVKLQFSRHH CCCCCEEEEEECHHH	31.47	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YRF14_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YRF14_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YRF14_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of YRF14_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.