FAT2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAT2_YEAST
• UniProt AC: P38137
• Protein Name: Peroxisomal-coenzyme A synthetase
• Gene Name: PCS60
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 543
• Subcellular Localization: Peroxisome matrix. Peroxisome membrane; Peripheral membrane protein.
• Protein Description: Non-essential protein involved in fatty acid metabolism..
• Protein Sequence: MTSAATVTASFNDTFSVSDNVAVIVPETDTQVTYRDLSHMVGHFQTMFTNPNSPLYGAVFRQDTVAISMRNGLEFIVAFLGATMDAKIGAPLNPNYKEKEFNFYLNDLKSKAICVPKGTTKLQSSEILKSASTFGCFIVELAFDATRFRVEYDIYSPEDNYKRVIYRSLNNAKFVNTNPVKFPGFARSSDVALILHTSGTTSTPKTVPLLHLNIVRSTLNIANTYKLTPLDRSYVVMPLFHVHGLIGVLLSTFRTQGSVVVPDGFHPKLFWDQFVKYNCNWFSCVPTISMIMLNMPKPNPFPHIRFIRSCSSALAPATFHKLEKEFNAPVLEAYAMTEASHQMTSNNLPPGKRKPGTVGQPQGVTVVILDDNDNVLPPGKVGEVSIRGENVTLGYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLTGRIKELINRGGEKISPIELDGIMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVNFLKKHLASFKIPTKVYFVDKLPKTATGKIQRRVIAETFAKSSRNKSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSAATVTA ------CCCCEEEEE	27.37	27017623
28	Phosphorylation	VAVIVPETDTQVTYR EEEEECCCCCEEEHH	37.97	27017623
30	Phosphorylation	VIVPETDTQVTYRDL EEECCCCCEEEHHHH	32.15	27017623
33	Phosphorylation	PETDTQVTYRDLSHM CCCCCEEEHHHHHHH	11.74	27017623
34	Phosphorylation	ETDTQVTYRDLSHMV CCCCEEEHHHHHHHH	11.85	27017623
99	Acetylation	LNPNYKEKEFNFYLN CCCCCCHHHCCEECC	64.55	24489116
173	Acetylation	YRSLNNAKFVNTNPV EECCCCCCCCCCCCC	52.55	24489116
224	Phosphorylation	STLNIANTYKLTPLD HHCCCCCCCCCCCCC	17.01	30377154
276	Acetylation	LFWDQFVKYNCNWFS HHHHHHHHCCCCCHH	31.84	25381059
297	Acetylation	MIMLNMPKPNPFPHI EHHCCCCCCCCCCCH	46.81	25381059
309	Phosphorylation	PHIRFIRSCSSALAP CCHHHHHHHHHHHCH	17.34	22369663
311	Phosphorylation	IRFIRSCSSALAPAT HHHHHHHHHHHCHHH	21.64	22369663
312	Phosphorylation	RFIRSCSSALAPATF HHHHHHHHHHCHHHH	31.46	22369663
318	Phosphorylation	SSALAPATFHKLEKE HHHHCHHHHHHHHHH	25.80	22369663
321	Acetylation	LAPATFHKLEKEFNA HCHHHHHHHHHHHCC	54.90	24489116
400	Acetylation	LGYANNPKANKENFT EEECCCCCCCCCCCC	67.71	24489116
434	Ubiquitination	LVLTGRIKELINRGG EEEHHHHHHHHHCCC	45.14	23749301
443	Acetylation	LINRGGEKISPIELD HHHCCCCCCCCEECC	52.32	24489116
515	Acetylation	TKVYFVDKLPKTATG CEEEEEECCCCCCCC	62.48	24489116
523	Ubiquitination	LPKTATGKIQRRVIA CCCCCCCHHHHHHHH	31.17	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAT2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAT2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAT2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAT2_YEAST	PCS60	physical	18467557
RV161_YEAST	RVS161	genetic	20093466
TPS2_YEAST	TPS2	genetic	20093466
RV167_YEAST	RVS167	genetic	20093466
COPE_YEAST	SEC28	genetic	20093466
YJ24_YEAST	KCH1	genetic	20093466
YMS4_YEAST	YMR034C	genetic	20093466
PFKA2_YEAST	PFK2	genetic	20093466
EOS1_YEAST	EOS1	genetic	20093466
INO4_YEAST	INO4	genetic	20093466
ASH1_YEAST	ASH1	physical	20844764
VPS34_YEAST	VPS34	physical	21121900
FAT2_YEAST	PCS60	physical	22615397
FAT2_YEAST	PCS60	physical	22940862
FAT2_YEAST	PCS60	physical	26359497

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.