VPS34_YEAST - dbPTM
VPS34_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS34_YEAST
UniProt AC P22543
Protein Name Phosphatidylinositol 3-kinase VPS34
Gene Name VPS34
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 875
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein . Endosome membrane
Peripheral membrane protein .
Protein Description Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity..
Protein Sequence MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
114PhosphorylationLRIILWEYNGSKQIP
EEEEEEEECCCCEEC		17.1628889911
117PhosphorylationILWEYNGSKQIPFFN
EEEEECCCCEECCCE		20.1128889911
438PhosphorylationTIVDAVSSQKLSGDS
EEEEHHHCCCCCCCC		25.4128889911
442PhosphorylationAVSSQKLSGDSMLLS
HHHCCCCCCCCEEEC		47.8121440633
449PhosphorylationSGDSMLLSTSHANQK
CCCCEEECCHHHCHH		24.7321440633
450PhosphorylationGDSMLLSTSHANQKL
CCCEEECCHHHCHHH		25.2221440633
451PhosphorylationDSMLLSTSHANQKLL
CCEEECCHHHCHHHH		19.7525752575
467PhosphorylationSISSESETSGTESLP
HHCCCCCCCCCCCCC		41.5619779198
468PhosphorylationISSESETSGTESLPI
HCCCCCCCCCCCCCE		39.4019779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS34_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS34_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS34_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS15_YEASTVPS15physical
8387919
GPA1_YEASTGPA1physical
16839886
VPS15_YEASTVPS15physical
11689570
BECN1_YEASTVPS30physical
20489023
ATG9_YEASTATG9physical
23904270
ATG11_YEASTATG11physical
23904270
BOS1_YEASTBOS1physical
23904270
ERP1_YEASTERP1physical
23904270
PIL1_YEASTPIL1physical
23904270
SDS24_YEASTSDS24physical
23904270
SLY1_YEASTSLY1physical
23904270
CLH_YEASTCHC1physical
23904270
EMP24_YEASTEMP24physical
23904270
ERV41_YEASTERV41physical
23904270
FTH1_YEASTFTH1physical
23904270
VPS10_YEASTPEP1physical
23904270
PEP3_YEASTPEP3physical
23904270
RCR2_YEASTRCR2physical
23904270
SAR1_YEASTSAR1physical
23904270
SEC18_YEASTSEC18physical
23904270
SEC23_YEASTSEC23physical
23904270
TLG1_YEASTTLG1physical
23904270
VAM3_YEASTVAM3physical
23904270
VPS24_YEASTVPS24physical
23904270
YIP1_YEASTYIP1physical
23904270
YPT32_YEASTYPT32physical
23904270
PEP5_YEASTPEP5physical
23904270
PRM8_YEASTPRM8physical
23904270
SVP26_YEASTSVP26physical
23904270
KC11_YEASTYCK1physical
23904270
YIF1_YEASTYIF1physical
23904270
BET1_YEASTBET1physical
23904270
NYV1_YEASTNYV1physical
23904270
COPG_YEASTSEC21physical
23904270
SEC22_YEASTSEC22physical
23904270
SED5_YEASTSED5physical
23904270
SFT1_YEASTSFT1physical
23904270
TVP38_YEASTTVP38physical
23904270
YOP1_YEASTYOP1physical
23904270
ATG14_YEASTATG14physical
23904270
STV1_YEASTSTV1physical
23904270
YPT52_YEASTYPT52physical
23904270
DID4_YEASTDID4physical
23904270
KC13_YEASTYCK3physical
23904270
ATC7_YEASTNEO1physical
23904270
SEC4_YEASTSEC4physical
23904270
AKR1_YEASTAKR1physical
23904270
SNF7_YEASTSNF7physical
23904270
SFT2_YEASTSFT2physical
23904270
GOSR1_YEASTGOS1physical
23904270
PEP12_YEASTPEP12physical
23904270
SS120_YEASTSSP120physical
23904270
YPT7_YEASTYPT7physical
23904270
TMEDA_YEASTERV25physical
23904270
VPS1_YEASTVPS1physical
23904270
PRA1_YEASTYIP3physical
23904270
EMP47_YEASTEMP47physical
23904270
YPT1_YEASTYPT1physical
23904270
SEC17_YEASTSEC17physical
23904270
YPT31_YEASTYPT31physical
23904270
VPS21_YEASTVPS21physical
23904270
CDC48_YEASTCDC48physical
23904270
VTI1_YEASTVTI1physical
23904270
DID2_YEASTDID2physical
23904270
VPS38_YEASTVPS38physical
23904270
SSO1_YEASTSSO1physical
23904270
ATC1_YEASTPMR1physical
23904270
BECN1_YEASTVPS30physical
23904270
CASP_YEASTCOY1physical
23904270
VPS15_YEASTVPS15physical
23904270
VPS34_YEASTVPS34physical
23904270
FKS1_YEASTFKS1physical
23904270
VPS15_YEASTVPS15physical
24165940
BECN1_YEASTVPS30physical
24165940
VPS38_YEASTVPS38physical
24165940
ATG14_YEASTATG14physical
24165940
ATG38_YEASTATG38physical
24165940
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS34_YEAST

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Related Literatures of Post-Translational Modification

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