NYV1_YEAST - dbPTM
NYV1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NYV1_YEAST
UniProt AC Q12255
Protein Name Vacuolar v-SNARE NYV1
Gene Name NYV1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 253
Subcellular Localization Vacuole membrane
Single-pass type IV membrane protein .
Protein Description Vacuolar v-SNARE required for docking. Only involved in homotypic vacuole fusion. Required for Ca(2+) efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca(2+)-ATPase PMC1 and promoting Ca(2+) release when forming trans-SNARE assemblies during the docking step..
Protein Sequence MKRFNVSYVEVIKNGETISSCFQPFQKNENYGTITSANEQITPVIFHNLIMDMVLPKVVPIKGNKVTKMSMNLIDGFDCFYSTDDHDPKTVYVCFTLVDMPKILPIRILSGLQEYESNATNELLSSHVGQILDSFHEELVEYRNQTLNSSGNGQSSNGNGQNTISDIGDATEDQIKDVIQIMNDNIDKFLERQERVSLLVDKTSQLNSSSNKFRRKAVNIKEIMWWQKVKNITLLTFTIILFVSAAFMFFYLW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
188UbiquitinationIMNDNIDKFLERQER
HHHHCHHHHHHHHHH		48.3124961812
197PhosphorylationLERQERVSLLVDKTS
HHHHHHHHHHHCCHH		23.3925752575
202UbiquitinationRVSLLVDKTSQLNSS
HHHHHHCCHHHCCCC		42.4723749301
203PhosphorylationVSLLVDKTSQLNSSS
HHHHHCCHHHCCCCC		19.7624961812
204PhosphorylationSLLVDKTSQLNSSSN
HHHHCCHHHCCCCCH		38.1123749301
208PhosphorylationDKTSQLNSSSNKFRR
CCHHHCCCCCHHHHH		43.6824961812
209PhosphorylationKTSQLNSSSNKFRRK
CHHHCCCCCHHHHHH		36.5427214570
210PhosphorylationTSQLNSSSNKFRRKA
HHHCCCCCHHHHHHC		43.8128889911
212UbiquitinationQLNSSSNKFRRKAVN
HCCCCCHHHHHHCCC		42.0423749301
216UbiquitinationSSNKFRRKAVNIKEI
CCHHHHHHCCCHHHH		53.0522817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NYV1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NYV1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NYV1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG8_YEASTATG8physical
10837468
VAM3_YEASTVAM3physical
10837468
VPS41_YEASTVPS41physical
10725336
VAM3_YEASTVAM3physical
10725336
YKT6_YEASTYKT6physical
10725336
VAM3_YEASTVAM3physical
10385523
VAM3_YEASTVAM3physical
9425154
BET1_YEASTBET1physical
11994317
SEC22_YEASTSEC22physical
11994317
SED5_YEASTSED5physical
11994317
ATC2_YEASTPMC1physical
11080502
NYV1_YEASTNYV1physical
16768461
AP3B_YEASTAPL6physical
16855025
ACT_YEASTACT1physical
17726018
NHX1_YEASTNHX1genetic
20826459
VAM3_YEASTVAM3physical
21934648
SHE3_YEASTSHE3genetic
21987634
VAM3_YEASTVAM3physical
22174414
VAM7_YEASTVAM7physical
22174414
STX8_YEASTSYN8physical
22174414
TLG1_YEASTTLG1physical
22174414
VTI1_YEASTVTI1physical
22174414
VPS33_YEASTVPS33physical
21613544
VPS16_YEASTVPS16physical
21613544
VPS41_YEASTVPS41physical
21613544
VAM7_YEASTVAM7physical
21987819
VAM3_YEASTVAM3physical
22272185
VAM6_YEASTVAM6physical
22272185
VAM7_YEASTVAM7physical
22272185
VTI1_YEASTVTI1physical
22272185
OSH6_YEASTOSH6genetic
22622083
HES1_YEASTHES1genetic
22622083
HSP72_YEASTSSA2physical
22940862
PDC1_YEASTPDC1physical
22940862
SRO9_YEASTSRO9physical
22940862
SSB1_YEASTSSB1physical
22940862
HSP7F_YEASTSSE1physical
22940862
G3P3_YEASTTDH3physical
22940862
KPYK1_YEASTCDC19physical
22940862
VATB_YEASTVMA2physical
22940862
G3P2_YEASTTDH2physical
22940862
EF1A_YEASTTEF2physical
22940862
DED1_YEASTDED1physical
22940862
PABP_YEASTPAB1physical
22940862
HSP71_YEASTSSA1physical
22940862
IVY1_YEASTIVY1physical
22875988
VAB2_YEASTVAB2physical
22875988
TSC11_YEASTTSC11physical
22875988
VAM7_YEASTVAM7physical
22875988
YH41A_YEASTYHL009W-Aphysical
22875988
SKN7_YEASTSKN7physical
22875988
YJ41B_YEASTYJL113Wphysical
22875988
VATC_YEASTVMA5physical
22875988
DID2_YEASTDID2physical
22875988
DYHC_YEASTDYN1physical
22875988
NKP2_YEASTNKP2physical
22875988
FAR3_YEASTFAR3physical
22875988
END3_YEASTEND3physical
22875988
LGE1_YEASTLGE1physical
22875988
VPS33_YEASTVPS33physical
23051737
ATC2_YEASTPMC1genetic
25017437
VAM3_YEASTVAM3physical
27252384
PEP12_YEASTPEP12physical
24589832
VTI1_YEASTVTI1physical
24589832
TLG1_YEASTTLG1physical
24589832
VAM3_YEASTVAM3physical
24589832
VAM7_YEASTVAM7physical
24589832
SED5_YEASTSED5physical
24589832
GOSR1_YEASTGOS1physical
24589832
BET1_YEASTBET1physical
24589832
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NYV1_YEAST

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Related Literatures of Post-Translational Modification

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