| UniProt ID | VATC_YEAST | |
|---|---|---|
| UniProt AC | P31412 | |
| Protein Name | V-type proton ATPase subunit C | |
| Gene Name | VMA5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 392 | |
| Subcellular Localization |
Vacuole membrane Peripheral membrane protein . |
|
| Protein Description | Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C acts as a flexible stator that holds together the catalytic and the membrane sectors of the enzyme. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section. Binds ATP and is likely to have a specific function in the catalytic activity of the catalytic sector. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.. | |
| Protein Sequence | MATALYTANDFILISLPQNAQPVTAPGSKTDSWFNETLIGGRAFVSDFKIPEFKIGSLDTLIVESEELSKVDNQIGASIGKIIEILQGLNETSTNAYRTLPINNMPVPEYLENFQWQTRKFKLDKSIKDLITLISNESSQLDADVRATYANYNSAKTNLAAAERKKTGDLSVRSLHDIVKPEDFVLNSEHLTTVLVAVPKSLKSDFEKSYETLSKNVVPASASVIAEDAEYVLFNVHLFKKNVQEFTTAAREKKFIPREFNYSEELIDQLKKEHDSAASLEQSLRVQLVRLAKTAYVDVFINWFHIKALRVYVESVLRYGLPPHFNIKIIAVPPKNLSKCKSELIDAFGFLGGNAFMKDKKGKINKQDTSLHQYASLVDTEYEPFVMYIINL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MATALYTAN ------CCCEEEECC | 11.11 | - | |
| 6 | Phosphorylation | --MATALYTANDFIL --CCCEEEECCCEEE | 11.01 | 28132839 | |
| 30 | Phosphorylation | VTAPGSKTDSWFNET CCCCCCCCCCCCCCC | 36.64 | 27017623 | |
| 32 | Phosphorylation | APGSKTDSWFNETLI CCCCCCCCCCCCCEE | 38.51 | 27017623 | |
| 49 | Acetylation | RAFVSDFKIPEFKIG CCEECCCCCCCEECC | 63.44 | 24489116 | |
| 57 | Phosphorylation | IPEFKIGSLDTLIVE CCCEECCCCCEEEEC | 26.92 | 21440633 | |
| 70 | Ubiquitination | VESEELSKVDNQIGA ECCHHHHHHHHHHHH | 67.25 | 24961812 | |
| 138 | Phosphorylation | ITLISNESSQLDADV HHHHHCCCCCCCHHH | 27.86 | 30377154 | |
| 139 | Phosphorylation | TLISNESSQLDADVR HHHHCCCCCCCHHHH | 28.69 | 30377154 | |
| 167 | Phosphorylation | AAAERKKTGDLSVRS HHHHHHHHCCCCHHC | 38.68 | 21126336 | |
| 171 | Phosphorylation | RKKTGDLSVRSLHDI HHHHCCCCHHCHHHC | 21.89 | 30377154 | |
| 180 | Acetylation | RSLHDIVKPEDFVLN HCHHHCCCHHHEEEC | 42.92 | 24489116 | |
| 203 | Acetylation | VAVPKSLKSDFEKSY EECCHHHHHHHHHHH | 55.88 | 22865919 | |
| 208 | Ubiquitination | SLKSDFEKSYETLSK HHHHHHHHHHHHHHH | 59.33 | 23749301 | |
| 208 | Acetylation | SLKSDFEKSYETLSK HHHHHHHHHHHHHHH | 59.33 | 24489116 | |
| 208 | Succinylation | SLKSDFEKSYETLSK HHHHHHHHHHHHHHH | 59.33 | 23954790 | |
| 241 | Acetylation | FNVHLFKKNVQEFTT EEHHHHHHCHHHHHH | 55.83 | 22865919 | |
| 271 | Acetylation | EELIDQLKKEHDSAA HHHHHHHHHHCCCHH | 50.94 | 24489116 | |
| 335 | Acetylation | KIIAVPPKNLSKCKS EEEEECCCCHHHHHH | 65.53 | 24489116 | |
| 338 | Phosphorylation | AVPPKNLSKCKSELI EECCCCHHHHHHHHH | 45.46 | 19795423 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VATC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VATC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VATC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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