ADY2_YEAST - dbPTM
ADY2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADY2_YEAST
UniProt AC P25613
Protein Name Accumulation of dyads protein 2
Gene Name ADY2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 283
Subcellular Localization Cell membrane
Multi-pass membrane protein . Vacuole membrane
Multi-pass membrane protein . Localizes to large detergent resistant patches of the cell membrane (DRM) enriched in ergosterol and sphingolipids (PubMed:17395151).
Protein Description Transporter protein required for ammonia export and acetate uptake and resistance. Necessary for up-regulation and down-regulation of meiotic plaque (MP) component levels in a dependency on external acetate. Has a role in ascus formation..
Protein Sequence MSDKEQTSGNTDLENAPAGYYSSHDNDVNGVAEDERPSHDSLGKIYTGGDNNEYIYIGRQKFLKSDLYQAFGGTLNPGLAPAPVHKFANPAPLGLSAFALTTFVLSMFNARAQGITVPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSYGGFWLSFAAIYIPWFGILEAYEDNESDLNNALGFYLLGWAIFTFGLTVCTMKSTVMFFLLFFLLALTFLLLSIGHFANRLGVTRAGGVLGVVVAFIAWYNAYAGVATKQNSYVLARPFPLPSTERVIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDKEQTSG
------CCHHHCCCC		58.3430377154
7Phosphorylation-MSDKEQTSGNTDLE
-CCHHHCCCCCCCCC		39.4329136822
8PhosphorylationMSDKEQTSGNTDLEN
CCHHHCCCCCCCCCC		29.7329136822
11PhosphorylationKEQTSGNTDLENAPA
HHCCCCCCCCCCCCC		45.5529136822
20PhosphorylationLENAPAGYYSSHDND
CCCCCCCCCCCCCCC		11.4129136822
21PhosphorylationENAPAGYYSSHDNDV
CCCCCCCCCCCCCCC		11.6329136822
22PhosphorylationNAPAGYYSSHDNDVN
CCCCCCCCCCCCCCC		16.8327214570
23PhosphorylationAPAGYYSSHDNDVNG
CCCCCCCCCCCCCCC		20.8129136822
38PhosphorylationVAEDERPSHDSLGKI
CCCCCCCCCCCCCCE		46.2627214570
41PhosphorylationDERPSHDSLGKIYTG
CCCCCCCCCCCEECC		33.3327214570
46PhosphorylationHDSLGKIYTGGDNNE
CCCCCCEECCCCCCC		11.6527214570
47PhosphorylationDSLGKIYTGGDNNEY
CCCCCEECCCCCCCE		37.8625005228
65PhosphorylationGRQKFLKSDLYQAFG
CCHHHHCCCHHHHHC		34.6927214570
277PhosphorylationARPFPLPSTERVIF-
EECCCCCCCCCCCC-		51.0527214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADY2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADY2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADY2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AGP3_YEASTAGP3physical
16093310
GEF1_YEASTGEF1physical
16093310
CYAA_YEASTCYR1genetic
22660623
ATO2_YEASTATO2physical
22579979
ADY2_YEASTADY2physical
22579979
TPS2_YEASTTPS2genetic
27708008
PALA_YEASTRIM20genetic
27708008
CDC15_YEASTCDC15genetic
27708008
CALM_YEASTCMD1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
SEC23_YEASTSEC23genetic
27708008
RBG1_YEASTRBG1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
EDE1_YEASTEDE1genetic
27708008
ATG8_YEASTATG8genetic
27708008
RTG3_YEASTRTG3genetic
27708008
CHS3_YEASTCHS3genetic
27708008
REG2_YEASTREG2genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
YPC1_YEASTYPC1genetic
27708008
DER1_YEASTDER1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SLX5_YEASTSLX5genetic
27708008
BRE1_YEASTBRE1genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
PCL2_YEASTPCL2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
UBC13_YEASTUBC13genetic
27708008
XRS2_YEASTXRS2genetic
27708008
DFM1_YEASTDFM1genetic
27708008
POLH_YEASTRAD30genetic
27708008
IES5_YEASTIES5genetic
27708008
SLX8_YEASTSLX8genetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
RAD4_YEASTRAD4genetic
27708008
SGF73_YEASTSGF73genetic
27708008
MMS2_YEASTMMS2genetic
27708008
VAM7_YEASTVAM7genetic
27708008
DBF2_YEASTDBF2genetic
27708008
ASK10_YEASTASK10genetic
27708008
NPR3_YEASTNPR3genetic
27708008
HTD2_YEASTHTD2genetic
27708008
PTH_YEASTPTH1genetic
27708008
PDR11_YEASTPDR11genetic
27708008
GPP1_YEASTGPP1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
RM49_YEASTMRP49genetic
27708008
VPS13_YEASTVPS13genetic
27708008
FPS1_YEASTFPS1genetic
27708008
HDA1_YEASTHDA1genetic
27708008
ATP23_YEASTATP23genetic
27708008
MSO1_YEASTMSO1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
YN9A_YEASTYNR071Cgenetic
27708008
DCAM_YEASTSPE2genetic
27708008
INO4_YEASTINO4genetic
27708008
MCP1_YEASTMCP1genetic
27708008
VPH1_YEASTVPH1genetic
27708008
PIP2_YEASTPIP2genetic
27708008
NIP80_YEASTNIP100genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADY2_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory