PIP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIP2_YEAST
• UniProt AC: P52960
• Protein Name: Peroxisome proliferation transcriptional regulator
• Gene Name: PIP2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 996
• Subcellular Localization: Nucleus.
• Protein Description: The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. Activity is inhibited by OAF1 under non-inducing conditions. Activity is repressed by glucose..
• Protein Sequence: MYFTDESSPAMNRVGKKRNRLSFVCQACRKAKTKCDQEKPRCGRCTKQNLFCIYDVARQAAPRNPNKDATIARLKKEIRYWRNKTVDLTQEKKDFYTALKRPTEELAARRTCKSLQENSFPISLYKTHPRLIMTKVMKREINPLSEKYLIFQDTFLKTLIASVLLSCSRNSMIPALNADISRSRTQPCVKNNVVKMREVLLKNSKYESQRKSINEFTDRLLQRKNPEEQIAVNKVISLLYSNRESSYLEDTCPTENDYSDLLKGYINEIEKTLPPKAIIEQYLSHFFEHIFHLIPFASKEMLEESIHTTVQYNELGEVRLSMGTTLIRNKMENLCILLLILRIAYISLTFIEDKIEDYSPYITKEMLEQYPIQSEVIFLAQQILASENWCACANENTISCLLYIWCAFVFSPTEGDFLLEQPSDVIINLVILIGTSIGLHRDPSDFPALNHPEASDKRLLNLRRIQWLSIISMATLESSLKGRLLVSPLSMIDLFIDVRDPNCVEIYKKRVKKDLTGSESDEQLLEIHEIFFHRAQLALFLSDLNNITISYSGSVPMDTLETLRVKANELLKNKFQLRSVDINIYDEEKTFQKLTFNSILNSISLSGQILGKLMMLRASIALMLYFETLAMERSECLSFFYKYFFQCCADTISLIRFFFLYFNGSYEKVLSSLVCFITTKVIQLAVPTTMFTLLVIIMRVELAKNMLLVKCNECNARGDISDLPEIKEKIKSLDTIKENFERLLLEVYLLASQNLRFKYFYIFKMLTLFDVFIQRLRKGQLFSGLFVKVDKDLTTKKIATMLELTLGINLDKSDHLIDRLKGKNLTVNFTLDQLYQIIKEFDRIKNIGVADPQNSLNPSKPNMKDNTPTIELLLNSSVENESVPPYSSSNDPTNVGNASTYSLAHNISNQNNEENMPPSIGSSESNRAAPNLNFMPINNNYNNSGSNINNNDNVKLPSNFKNYYDPPMSSLDISMDVPDIFGSLDFFDYDLLFQND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYFTDESSP ------CCCCCCCCC	18.39	28132839
100	Acetylation	KDFYTALKRPTEELA HHHHHHHHCCHHHHH	54.59	24489116
158	Phosphorylation	FQDTFLKTLIASVLL CHHHHHHHHHHHHHH	26.08	21126336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIP2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OAF1_YEAST	OAF1	physical	12709061
OAF1_YEAST	OAF1	physical	9288897
PRI1_YEAST	PRI1	genetic	8668138
OAF1_YEAST	OAF1	physical	18671944
OAF1_YEAST	OAF1	physical	18285336
YRM1_YEAST	YRM1	genetic	20959818
YPT6_YEAST	YPT6	genetic	20959818
CTK1_YEAST	CTK1	genetic	21127252
MGA2_YEAST	MGA2	genetic	21127252
GPR1_YEAST	GPR1	genetic	27708008
UBC3_YEAST	CDC34	genetic	27708008
BCP1_YEAST	BCP1	genetic	27708008
SPC97_YEAST	SPC97	genetic	27708008
CDC6_YEAST	CDC6	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
CSG2_YEAST	CSG2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.