OAF1_YEAST - dbPTM
OAF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OAF1_YEAST
UniProt AC P39720
Protein Name Oleate-activated transcription factor 1
Gene Name OAF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1047
Subcellular Localization Nucleus.
Protein Description The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. OAF1 acts as the sensor for oleate and inhibits PIP2 activity under non-inducing conditions. Activity is repressed by glucose..
Protein Sequence MVENSTQKAPHAGNDDNSSTKPYSEAFFLGFNNPTPGLEAEHSSTSPAPENSETHNRKRNRILFVCQACRKSKTKCDREKPECGRCVKHGLKCVYDVSKQPAPRIPSKDAIISRLEKDMFYWKDKAMKLLTEREVNESGKRSASPINTNNASGDSPDTKKQHKMEPIYEQSGNGDINNGTRNDIEINLYRSHPTMIMSKVMKREVKPLSENYIIIQDCFLKILVTSVFLDTSKNTMIPALTANANITRAQPSVANNLLKLKEMLIRQCQTEDEKNRVNEFTDRILQNTNSNRNLKIGMLLSMLYNSVGYQYLEDHCPQGGEYSDLLRNLINECEAILPSYEIIERYKNHFYEYVYPSLPFIELEIFEESLSQTIFPDPNNPSKVQIRMGSTHLRAKVENLSLLLVILKLSYMSIRFLDHSTADSSFYLSKEIIDKYPIPNDFILLSQRCLASENWCACANENIISCLLYIWSFFAFSPEEGDFFLEHPTDVISSLIMMLSTSIGLHRDPSDFPQLISPSTSDKRTLNHRRILWLSIVTVCSFEASLKGRHSVSPISLMALFLNIKDPDSLTVYMNRVRGDLSDINNHKLLRIHKFTFKRAQLALLLSDLDNLTMTYYGSFHLHSIEFIREKIEIFVEENFPIVPLKSVAQDKSDLDDMNVISEMNILSSENSSSFHNRIMNKLLMLRTSMAVFLHFETLITKDKSIFPFYKKYFMVSCMDALSLINYFNKFFNGEYRHAISSLTSFNVTKFIQLALSSTIFSLLGIILRIGLAIHMLSSEVQKLSGTTDPRIKELNTKVEKFSTLQRDLESALEGIYCSASEHLRFTYFPVFKMLALFDVIVQRMRKGELWHGIFTMIQMEQMHSRIIKTLSITLGVKLDKKDRLLEELMACNHVANFSVEDIDELNRNIKKEIQISSGLKPPVNTIDLTNGEPFGNAVPTFTKTWSSSLDNLEKLSSAAAVGQSLDYNSGLRQGPLAGGGSKEQTPIAGMNNLNNSINATPIVDNSSGSQLPNGFDRGQANNTPFPGYFGGLDLFDYDFLFGNDFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationNSSTKPYSEAFFLGF
CCCCCCCCHHEEECC		30.8628889911
35PhosphorylationFLGFNNPTPGLEAEH
EECCCCCCCCCCCCC		31.9228889911
44PhosphorylationGLEAEHSSTSPAPEN
CCCCCCCCCCCCCCC		34.5121551504
46PhosphorylationEAEHSSTSPAPENSE
CCCCCCCCCCCCCCC		22.4727214570
131PhosphorylationDKAMKLLTEREVNES
HHHHHHHHHHCCCCC		43.3521551504
138PhosphorylationTEREVNESGKRSASP
HHHCCCCCCCCCCCC		44.4020377248
142PhosphorylationVNESGKRSASPINTN
CCCCCCCCCCCCCCC		36.2622369663
144PhosphorylationESGKRSASPINTNNA
CCCCCCCCCCCCCCC		27.7922369663
148PhosphorylationRSASPINTNNASGDS
CCCCCCCCCCCCCCC		30.4825521595
152PhosphorylationPINTNNASGDSPDTK
CCCCCCCCCCCCCHH		45.3022369663
155PhosphorylationTNNASGDSPDTKKQH
CCCCCCCCCCHHHHH		28.3522369663
158PhosphorylationASGDSPDTKKQHKME
CCCCCCCHHHHHCCC		43.4522369663
194PhosphorylationNLYRSHPTMIMSKVM
EEECCCCHHHHHHHH		17.5727017623
198PhosphorylationSHPTMIMSKVMKREV
CCCHHHHHHHHHCCC		15.9227017623
270PhosphorylationMLIRQCQTEDEKNRV
HHHHHHCCHHHHHHH		53.6922369663
304PhosphorylationGMLLSMLYNSVGYQY
HHHHHHHHHHHCHHH		9.2127017623
309PhosphorylationMLYNSVGYQYLEDHC
HHHHHHCHHHHHHHC		7.5727017623
322PhosphorylationHCPQGGEYSDLLRNL
HCCCCCCHHHHHHHH		15.6827017623
323PhosphorylationCPQGGEYSDLLRNLI
CCCCCCHHHHHHHHH		19.9227017623
382PhosphorylationFPDPNNPSKVQIRMG
CCCCCCCCCEEEECC		47.8119823750
390PhosphorylationKVQIRMGSTHLRAKV
CEEEECCCHHHHHHH		11.8719823750
391PhosphorylationVQIRMGSTHLRAKVE
EEEECCCHHHHHHHH		21.1419823750
653PhosphorylationKSVAQDKSDLDDMNV
HHHCCCCCCCCCCHH		52.2628889911
668PhosphorylationISEMNILSSENSSSF
HHHHHHCCCCCCHHH		31.6328889911
669PhosphorylationSEMNILSSENSSSFH
HHHHHCCCCCCHHHH		37.0328889911
672PhosphorylationNILSSENSSSFHNRI
HHCCCCCCHHHHHHH		24.2530377154
673PhosphorylationILSSENSSSFHNRIM
HCCCCCCHHHHHHHH		48.9121551504
713PhosphorylationIFPFYKKYFMVSCMD
CHHHHHHHHHHHHHH		7.8621440633
797PhosphorylationPRIKELNTKVEKFST
HHHHHHHHHHHHHHH		49.4428889911
947PhosphorylationPTFTKTWSSSLDNLE
CCCCHHHCCCHHHHH		18.4528152593
948PhosphorylationTFTKTWSSSLDNLEK
CCCHHHCCCHHHHHH		26.8722369663
949PhosphorylationFTKTWSSSLDNLEKL
CCHHHCCCHHHHHHH		33.9422369663
970PhosphorylationGQSLDYNSGLRQGPL
HCCCCCCCCCCCCCC		32.7324961812
982PhosphorylationGPLAGGGSKEQTPIA
CCCCCCCCCCCCCCC		35.9722369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OAF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OAF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OAF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PIP2_YEASTPIP2physical
8972187
OAF1_YEASTOAF1physical
9288897
YC16_YEASTYCR087C-Aphysical
16554755
MAK21_YEASTMAK21physical
16554755
RRP17_YEASTRRP17physical
16554755
ACA2_YEASTCST6physical
16554755
EBP2_YEASTEBP2physical
16554755
NOP56_YEASTNOP56physical
16554755
NOP58_YEASTNOP58physical
16554755
NOP53_YEASTNOP53physical
16554755
JIP5_YEASTJIP5physical
16554755
OAF1_YEASTOAF1physical
18671944
PIP2_YEASTPIP2physical
18285336
UBP3_YEASTUBP3genetic
20959818
BMH1_YEASTBMH1genetic
25355315
MRM2_YEASTMRM2genetic
27708008
XRN1_YEASTXRN1genetic
27708008
ICE2_YEASTICE2genetic
27708008
MGA2_YEASTMGA2genetic
27708008
VPS51_YEASTVPS51genetic
27708008
ODP2_YEASTLAT1genetic
28520713
ODPA_YEASTPDA1genetic
28520713
ODPB_YEASTPDB1genetic
28520713
ODPX_YEASTPDX1genetic
28520713
DLDH_YEASTLPD1genetic
28520713
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OAF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-947 ANDSER-949, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144 AND SER-155, ANDMASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144 AND SER-155, ANDMASS SPECTROMETRY.

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