ATO2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATO2_YEAST
• UniProt AC: P32907
• Protein Name: Ammonia transport outward protein 2
• Gene Name: ATO2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 282
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localizes to large detergent resistant patches of the cell membrane (DRM) enriched in ergosterol and sphingolipids.
• Protein Description: Transporter protein required for ammonia export. Involved in acetate resistance..
• Protein Sequence: MSDREQSSGNTAFENPKALDSSEGEFISENNDQSRHSQESICKIYTAGKNNEYIYIGRQKFLRDDLFEAFGGTLNPGLAPAPVHKFANPAPLGLSGFALTTFVLSMFNARAQGITIPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSFGGFWLSFGAIYIPWFGILDAYKDKESDLGNALGFYLLGWALFTFGLSVCTMKSTIMFFALFFLLAVTFLLLSIANFTGEVGVTRAGGVLGVIVAFIAWYNAYAGIATRQNSYIMVHPFALPSNDKVFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDREQSSG ------CCHHHCCCC	45.43	17761666
2	Phosphorylation	------MSDREQSSG ------CCHHHCCCC	45.43	29136822
7	Phosphorylation	-MSDREQSSGNTAFE -CCHHHCCCCCCCCC	35.15	27214570
11	Phosphorylation	REQSSGNTAFENPKA HHCCCCCCCCCCCCC	35.93	29734811
21	Phosphorylation	ENPKALDSSEGEFIS CCCCCCCCCCCCCCC	31.01	29136822
22	Phosphorylation	NPKALDSSEGEFISE CCCCCCCCCCCCCCC	49.65	29136822
28	Phosphorylation	SSEGEFISENNDQSR CCCCCCCCCCCCCCC	39.32	29136822
37	Phosphorylation	NNDQSRHSQESICKI CCCCCCCCHHHHHHE	34.24	29136822
40	Phosphorylation	QSRHSQESICKIYTA CCCCCHHHHHHEEEC	26.16	29136822

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATO2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATO2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATO2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CWH41_YEAST	CWH41	physical	16093310
ORT1_YEAST	ORT1	physical	16093310
MCM7_YEAST	MCM7	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
FAL1_YEAST	FAL1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
RRP41_YEAST	SKI6	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
PRP19_YEAST	PRP19	genetic	27708008
MED14_YEAST	RGR1	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
OST2_YEAST	OST2	genetic	27708008
ORC4_YEAST	ORC4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-7; SER-21;SER-22; SER-28 AND SER-40, AND MASS SPECTROMETRY.
PubMed: 17761666