GEF1_YEAST - dbPTM
GEF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GEF1_YEAST
UniProt AC P37020
Protein Name Anion/proton exchange transporter GEF1
Gene Name GEF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 779
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein . Endosome membrane
Multi-pass membrane protein . Prevacuolar compartment membrane
Multi-pass membrane protein .
Protein Description Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane..
Protein Sequence MPTTYVPINQPIGDGEDVIDTNRFTNIPETQNFDQFVTIDKIAEENRPLSVDSDREFLNSKYRHYREVIWDRAKTFITLSSTAIVIGCIAGFLQVFTETLVNWKTGHCQRNWLLNKSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAWKGHVSPFIIFMLLSVLFALISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALPLAISSGLSVGKEGPSVHYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGAPIGGVLFGLEEIASANRFNSSTLWKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRDWKVQEIPIFIALGIFGGLYGKYISKWNINFIHFRKMYLSSWPVQEVLFLATLTALISYFNEFLKLDMTESMGILFHECVKNDNTSTFSHRLCQLDENTHAFEFLKIFTSLCFATVIRALLVVVSYGARVPAGIFVPSMAVGATFGRAVSLLVERFISGPSVITPGAYAFLGAAATLSGITNLTLTVVVIMFELTGAFMYIIPLMIVVAITRIILSTSGISGGIADQMIMVNGFPYLEDEQDEEEEETLEKYTAEQLMSSKLITINETIYLSELESLLYDSASEYSVHGFPITKDEDKFEKEKRCIGYVLKRHLASKIMMQSVNSTKAQTTLVYFNKSNEELGHRENCIGFKDIMNESPISVKKAVPVTLLFRMFKELGCKTIIVEESGILKGLVTAKDILRFKRIKYREVHGAKFTYNEALDRRCWSVIHFIIKRFTTNRNGNVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationAEENRPLSVDSDREF
HHHCCCCCCCCCHHH		26.9319779198
53PhosphorylationNRPLSVDSDREFLNS
CCCCCCCCCHHHHHH		36.0921440633
61UbiquitinationDREFLNSKYRHYREV
CHHHHHHHHHHHHHH		45.2724961812
214PhosphorylationFLTLVIKSVALPLAI
HHHHHHHHCHHHHHH		11.0828889911
226PhosphorylationLAISSGLSVGKEGPS
HHHHCCCCCCCCCCC		32.1428889911
691PhosphorylationFKDIMNESPISVKKA
HHHHHCCCCCCHHHH		23.6425882841
694PhosphorylationIMNESPISVKKAVPV
HHCCCCCCHHHHHHH		31.1325882841
725UbiquitinationVEESGILKGLVTAKD
EECCCHHCCCCCHHH		48.5617644757
731UbiquitinationLKGLVTAKDILRFKR
HCCCCCHHHHHHHHC		35.6217644757
737UbiquitinationAKDILRFKRIKYREV
HHHHHHHHCCEEEEE		46.9417644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GEF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GEF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GEF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GDA1_YEASTGDA1genetic
16269340
ATC3_YEASTDRS2genetic
16269340
VPS52_YEASTVPS52genetic
16269340
RIC1_YEASTRIC1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
ATC1_YEASTPMR1genetic
16269340
GWT1_YEASTGWT1genetic
16269340
OST1_YEASTOST1genetic
16269340
OSTB_YEASTWBP1genetic
16269340
TRS20_YEASTTRS20genetic
16269340
COPE_YEASTSEC28genetic
16269340
BFR1_YEASTBFR1genetic
16269340
GET3_YEASTGET3physical
16260785
LTE1_YEASTLTE1genetic
20093466
IPT1_YEASTIPT1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
PEX3_YEASTPEX3genetic
20093466
URC2_YEASTURC2genetic
20093466
RTG2_YEASTRTG2genetic
20093466
RTF1_YEASTRTF1genetic
20093466
ATC1_YEASTPMR1genetic
20093466
COG7_YEASTCOG7genetic
20093466
SMI1_YEASTSMI1genetic
20093466
BUD2_YEASTBUD2genetic
20093466
VPS51_YEASTVPS51genetic
20093466
RIM13_YEASTRIM13genetic
20093466
FET4_YEASTFET4genetic
20093466
MKS1_YEASTMKS1genetic
20093466
DFG16_YEASTDFG16genetic
20093466
AIM44_YEASTAIM44genetic
20093466
SUR1_YEASTSUR1genetic
20093466
VAM7_YEASTVAM7physical
16093310
ECM3_YEASTECM3physical
16093310
SNC2_YEASTSNC2genetic
20526336
MVB12_YEASTMVB12genetic
20526336
SUR1_YEASTSUR1genetic
20526336
SWA2_YEASTSWA2genetic
20526336
RIC1_YEASTRIC1genetic
20526336
PRM9_YEASTPRM9genetic
20526336
GYP5_YEASTGYP5genetic
20526336
SLT2_YEASTSLT2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
CSG2_YEASTCSG2genetic
27708008
MTC4_YEASTMTC4genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
IPT1_YEASTIPT1genetic
27708008
SWF1_YEASTSWF1genetic
27708008
SWA2_YEASTSWA2genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
COG7_YEASTCOG7genetic
27708008
SMI1_YEASTSMI1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
BUD2_YEASTBUD2genetic
27708008
IRS4_YEASTIRS4genetic
27708008
VPS51_YEASTVPS51genetic
27708008
YPT6_YEASTYPT6genetic
27708008
ELO3_YEASTELO3genetic
27708008
VID22_YEASTVID22genetic
27708008
COG8_YEASTCOG8genetic
27708008
COG6_YEASTCOG6genetic
27708008
COG5_YEASTCOG5genetic
27708008
MKS1_YEASTMKS1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
GYP1_YEASTGYP1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
FUMH_YEASTFUM1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GEF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 AND SER-226, ANDMASS SPECTROMETRY.

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