SNC2_YEAST - dbPTM
SNC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNC2_YEAST
UniProt AC P33328
Protein Name Synaptobrevin homolog 2
Gene Name SNC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 115
Subcellular Localization Endomembrane system
Single-pass type IV membrane protein. Post-Golgi vesicle membrane.
Protein Description SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion..
Protein Sequence MSSSVPYDPYVPPEESNSGANPNSQNKTAALRQEIDDTVGIMRDNINKVAERGERLTSIEDKADNLAISAQGFKRGANRVRKQMWWKDLKMRMCLFLVVIILLVVIIVPIVVHFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSVPYDP
------CCCCCCCCC		31.1830377154
3Phosphorylation-----MSSSVPYDPY
-----CCCCCCCCCC		33.7730377154
4Phosphorylation----MSSSVPYDPYV
----CCCCCCCCCCC		21.5830377154
10PhosphorylationSSVPYDPYVPPEESN
CCCCCCCCCCCCCCC		23.7730377154
16PhosphorylationPYVPPEESNSGANPN
CCCCCCCCCCCCCCC		34.3330377154
24PhosphorylationNSGANPNSQNKTAAL
CCCCCCCCCCHHHHH		36.0730377154
27UbiquitinationANPNSQNKTAALRQE
CCCCCCCHHHHHHHH		31.7224961812
48UbiquitinationIMRDNINKVAERGER
HHHHHHHHHHHHHHC		38.7423749301
57PhosphorylationAERGERLTSIEDKAD
HHHHHCCCCHHHHHH		33.6020377248
58PhosphorylationERGERLTSIEDKADN
HHHHCCCCHHHHHHH		28.6819823750
62AcetylationRLTSIEDKADNLAIS
CCCCHHHHHHHHHHH		44.8624489116
62UbiquitinationRLTSIEDKADNLAIS
CCCCHHHHHHHHHHH		44.8623749301
69PhosphorylationKADNLAISAQGFKRG
HHHHHHHHHHHHHHH		14.6621440633
74AcetylationAISAQGFKRGANRVR
HHHHHHHHHHHHHHH		57.6624489116
74UbiquitinationAISAQGFKRGANRVR
HHHHHHHHHHHHHHH		57.6623749301
94S-palmitoylationKDLKMRMCLFLVVII
HHHHHHHHHHHHHHH		1.3915973437
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNC2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNC2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNC2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEC1_YEASTSEC1physical
10427089
DDI1_YEASTDDI1physical
10330187
SSO1_YEASTSSO1physical
10924463
BET1_YEASTBET1physical
11994317
BOS1_YEASTBOS1physical
11994317
SEC22_YEASTSEC22physical
11994317
SED5_YEASTSED5physical
11994317
SLY1_YEASTSLY1physical
11994317
SED5_YEASTSED5physical
11251068
TLG1_YEASTTLG1physical
11251068
VTI1_YEASTVTI1physical
11251068
SEC9_YEASTSEC9physical
9799229
SEC9_YEASTSEC9physical
10924463
SPO20_YEASTSPO20physical
10924463
PP11_YEASTSIT4genetic
12006655
CLH_YEASTCHC1genetic
11847108
PEP12_YEASTPEP12genetic
11847108
VAM3_YEASTVAM3genetic
11847108
VPS1_YEASTVPS1genetic
11847108
VPS34_YEASTVPS34genetic
11847108
SEC9_YEASTSEC9genetic
8089101
SEC9_YEASTSEC9genetic
11080147
SSO1_YEASTSSO1physical
16452633
SEC1_YEASTSEC1physical
15466482
VPS45_YEASTVPS45physical
16769821
ELO2_YEASTELO2genetic
9832547
ELO3_YEASTELO3genetic
9832547
SPO20_YEASTSPO20genetic
19064671
SSO1_YEASTSSO1physical
19591838
SSO1_YEASTSSO1physical
19776355
SEC9_YEASTSEC9physical
19776355
SNG1_YEASTSNG1physical
16093310
VMR1_YEASTVMR1physical
16093310
MDL2_YEASTMDL2physical
16093310
SEC17_YEASTSEC17genetic
9195971
SEC9_YEASTSEC9genetic
9195971
SSO2_YEASTSSO2genetic
9195971
SSO1_YEASTSSO1physical
21119007
SSO2_YEASTSSO2physical
21119007
TPM1_YEASTTPM1genetic
20526336
SRO7_YEASTSRO7genetic
20526336
SPO14_YEASTSPO14genetic
20526336
SEC9_YEASTSEC9physical
7954793
TPM1_YEASTTPM1genetic
23891562
SEC6_YEASTSEC6genetic
23891562
SEC9_YEASTSEC9genetic
23891562
ARF3_YEASTARF3genetic
23891562
SNC1_YEASTSNC1genetic
23891562
SEC5_YEASTSEC5physical
23897890
SEC6_YEASTSEC6physical
23897890
SEC8_YEASTSEC8physical
23897890
SEC15_YEASTSEC15physical
23897890
EXO70_YEASTEXO70physical
23897890
SEC10_YEASTSEC10physical
23897890
SEC3_YEASTSEC3physical
23897890
EXO84_YEASTEXO84physical
23897890
SEC9_YEASTSEC9physical
23897890
MAK16_YEASTMAK16genetic
27708008
CDC24_YEASTCDC24genetic
27708008
TSC3_YEASTTSC3genetic
27708008
NOT1_YEASTCDC39genetic
27708008
RPN6_YEASTRPN6genetic
27708008
COPB_YEASTSEC26genetic
27708008
GPI8_YEASTGPI8genetic
27708008
PANK_YEASTCAB1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
PRS8_YEASTRPT6genetic
27708008
YIP1_YEASTYIP1genetic
27708008
RPN1_YEASTRPN1genetic
27708008
LIP1_YEASTLIP1genetic
27708008
THIL_YEASTERG10genetic
27708008
PSB5_YEASTPRE2genetic
27708008
KPC1_YEASTPKC1genetic
27708008
EXO84_YEASTEXO84genetic
27708008
CALM_YEASTCMD1genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
CDK1_YEASTCDC28genetic
27708008
AME1_YEASTAME1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP11_YEASTPRP11genetic
27708008
YRB1_YEASTYRB1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
SEC5_YEASTSEC5genetic
27708008
MSS4_YEASTMSS4genetic
27708008
SYF1_YEASTSYF1genetic
27708008
TSC11_YEASTTSC11genetic
27708008
GDI1_YEASTGDI1genetic
27708008
SEC4_YEASTSEC4genetic
27708008
CAK1_YEASTCAK1genetic
27708008
ACT_YEASTACT1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
COPB2_YEASTSEC27genetic
27708008
SEC15_YEASTSEC15genetic
27708008
PRP18_YEASTPRP18genetic
27708008
OKP1_YEASTOKP1genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
RHO3_YEASTRHO3genetic
27708008
STS1_YEASTSTS1genetic
27708008
EXO70_YEASTEXO70genetic
27708008
PRP21_YEASTPRP21genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SN114_YEASTSNU114genetic
27708008
TOR2_YEASTTOR2genetic
27708008
GRC3_YEASTGRC3genetic
27708008
PRP19_YEASTPRP19genetic
27708008
NSE1_YEASTNSE1genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC10_YEASTSEC10genetic
27708008
RSE1_YEASTRSE1genetic
27708008
ERB1_YEASTERB1genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
NOP2_YEASTNOP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
PRP2_YEASTPRP2genetic
27708008
PROF_YEASTPFY1genetic
27708008
SEC62_YEASTSEC62genetic
27708008
SEC8_YEASTSEC8genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PEP12_YEASTPEP12physical
24589832
VTI1_YEASTVTI1physical
24589832
TLG1_YEASTTLG1physical
24589832
VAM3_YEASTVAM3physical
24589832
VAM7_YEASTVAM7physical
24589832
SED5_YEASTSED5physical
24589832
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNC2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-62, AND MASSSPECTROMETRY.

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