dbPTM

SPO20_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPO20_YEAST
UniProt AC	Q04359
Protein Name	Sporulation-specific protein 20
Gene Name	SPO20
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	397
Subcellular Localization	Cell membrane. Prospore membrane. Membrane-associated to the plasma during vegetative growth and prospore membrane associated during sporulation.
Protein Description	Required to maintain the prospore membrane to the nucleus during sporulation in order to capture the daughter nuclei and form the spores. Mediates the fusion of exocytic vesicles with the plasma membrane during sporulation through its interactions with the t-SNARE SSO1 and v-SNARE SNC2..
Protein Sequence	MGFRKILASKSHHSRHHNQHHKNLKLQNHRYVLISNITGSHETKYLSPFRMDNCSGSRRRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTSDDKCVSYEVPERDGLATISLEEVFPKSNRCQIPEENLGETDSVIHRDLGNFANENDYPQWRKVESQYNLENVQPEEDEIVDRLRSEIRSTKLKSVKTTSRTLEKAIEARCTGKRVLQQLSCQSNQLTKIESNCDMLKIQSNVADRKIDELAHENRSLLALKSPNPFRKKREREKRDQIYNLKLKHRHLQQETMKRAQDSDKNLAINLSSEYGRYGQGVERQRILRDAQKYQFEADEEDNQMEIDLYGNLEQIKAVSGDLKIMAHAFGREFEAQNTRMFDIENNVQQADNALQAKRYRLEKVIGKRW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	TGSHETKYLSPFRMD CCCCCCCCCCCCCCC	21.60	28889911
300	Phosphorylation	NLAINLSSEYGRYGQ CEEHHCCCCCCCCCC	37.69	28889911
302	Phosphorylation	AINLSSEYGRYGQGV EHHCCCCCCCCCCCH	14.62	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPO20_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPO20_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPO20_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSO1_YEAST	SSO1	physical	17714435
SSO2_YEAST	SSO2	physical	17714435
SSO1_YEAST	SSO1	physical	19064671
SNC2_YEAST	SNC2	physical	19064671
MSS4_YEAST	MSS4	genetic	15020409
SPO14_YEAST	SPO14	genetic	15020409
KTR7_YEAST	KTR7	genetic	23891562
YCY0_YEAST	YCR090C	genetic	27708008
GPI11_YEAST	GPI11	genetic	27708008
LTE1_YEAST	LTE1	genetic	27708008
CHK1_YEAST	CHK1	genetic	27708008
RLA1_YEAST	RPP1A	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
LCMT1_YEAST	PPM1	genetic	27708008
VAM7_YEAST	VAM7	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
ICE2_YEAST	ICE2	genetic	27708008
VPS24_YEAST	VPS24	genetic	27708008
SMY1_YEAST	SMY1	genetic	27708008
YRA2_YEAST	YRA2	genetic	27708008
LDB18_YEAST	LDB18	genetic	27708008
EIF3J_YEAST	HCR1	genetic	27708008
VAC14_YEAST	VAC14	genetic	27708008
BUL1_YEAST	BUL1	genetic	27708008
PET8_YEAST	PET8	genetic	27708008
COG6_YEAST	COG6	genetic	27708008
FKBP_YEAST	FPR1	genetic	27708008
ATP23_YEAST	ATP23	genetic	27708008
COX10_YEAST	COX10	genetic	27708008
NIP80_YEAST	NIP100	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPO20_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-45, AND MASSSPECTROMETRY.	18407956 [Abstract]