| UniProt ID | MSS4_YEAST | |
|---|---|---|
| UniProt AC | P38994 | |
| Protein Name | Probable phosphatidylinositol 4-phosphate 5-kinase MSS4 | |
| Gene Name | MSS4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 779 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton.. | |
| Protein Sequence | MSVLRSQPPSVVPLHLTTSTSRKTEQEPSLLHSAIIERHQDRSVPNSNSNPDSNHRIKKDRNNHTSYHSSSNSESNMESPRLSDGESSTPTSIEELNPTINNSRLVKRNYSISIDPLHDNSNNNTDDDHPNTITSPRPNSTSNKEMQKYSFPEGKESKKITTPSLNSNNCLDLDNSSLVHTDSYIQDLNDDHILLNKRVSRRSSRISAVTATSTTIKQRRNTQDSNLPNIPFHASKHSQILPMDDSDVIKLANGDTSMKPNSATKISHSMTSLPLHPLPQPSQKSKQYHMISKSTTSLPPENDHYYQHSRGTNHNHAANAAAVNNNTTTTTAATGLKRSESATAEIKKMRQSLLHKREMKRKRKTFLVDDDRVLIGNKVSEGHVNFIIAYNMLTGIRVAVSRCSGIMKPLTPADFRFTKKLAFDYHGNELTPSSQYAFKFKDYCPEVFRELRALFGLDPADYLVSLTSKYILSELNSPGKSGSFFYYSRDYKYIIKTIHHSEHIHLRKHIQEYYNHVRDNPNTLICQFYGLHRVKMPISFQNKIKHRKIYFLVMNNLFPPHLDIHITYDLKGSTWGRFTNLDKERLAKDRSYRPVMKDLNWLEEGQKIKFGPLKKKTFLTQLKKDVELLAKLNTMDYSLLIGIHDINKAKEDDLQLADTASIEEQPQTQGPIRTGTGTVVRHFFREFEGGIRASDQFNNDVDLIYYVGIIDFLTNYSVMKKLETFWRSLRHDTKLVSAIPPRDYANRFYEFIEDSVDPLPQKKTQSSYRDDPNQKNYKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | VLRSQPPSVVPLHLT CCCCCCCCEEEEEEE | 42.29 | 28889911 | |
| 17 | Phosphorylation | SVVPLHLTTSTSRKT CEEEEEEECCCCCCC | 14.14 | 19779198 | |
| 19 | Phosphorylation | VPLHLTTSTSRKTEQ EEEEEECCCCCCCCC | 21.10 | 23749301 | |
| 21 | Phosphorylation | LHLTTSTSRKTEQEP EEEECCCCCCCCCCC | 31.39 | 25752575 | |
| 53 | Phosphorylation | NSNSNPDSNHRIKKD CCCCCCCCCCCCCCC | 35.47 | 28889911 | |
| 73 | Phosphorylation | SYHSSSNSESNMESP CCCCCCCCCCCCCCC | 44.33 | 28889911 | |
| 83 | Phosphorylation | NMESPRLSDGESSTP CCCCCCCCCCCCCCC | 44.86 | 28889911 | |
| 111 | Phosphorylation | RLVKRNYSISIDPLH HHHCCCEEEEECCCC | 17.26 | 28889911 | |
| 113 | Phosphorylation | VKRNYSISIDPLHDN HCCCEEEEECCCCCC | 18.26 | 28889911 | |
| 121 | Phosphorylation | IDPLHDNSNNNTDDD ECCCCCCCCCCCCCC | 47.17 | 21440633 | |
| 125 | Phosphorylation | HDNSNNNTDDDHPNT CCCCCCCCCCCCCCC | 42.82 | 21440633 | |
| 132 | Phosphorylation | TDDDHPNTITSPRPN CCCCCCCCCCCCCCC | 30.04 | 21551504 | |
| 134 | Phosphorylation | DDHPNTITSPRPNST CCCCCCCCCCCCCCC | 30.55 | 19779198 | |
| 149 | Phosphorylation | SNKEMQKYSFPEGKE CCHHHHHCCCCCCCC | 9.92 | 27717283 | |
| 150 | Phosphorylation | NKEMQKYSFPEGKES CHHHHHCCCCCCCCC | 41.16 | 27717283 | |
| 161 | Phosphorylation | GKESKKITTPSLNSN CCCCCCCCCCCCCCC | 41.35 | 21551504 | |
| 162 | Phosphorylation | KESKKITTPSLNSNN CCCCCCCCCCCCCCC | 17.85 | 21440633 | |
| 164 | Phosphorylation | SKKITTPSLNSNNCL CCCCCCCCCCCCCCE | 37.78 | 20377248 | |
| 167 | Phosphorylation | ITTPSLNSNNCLDLD CCCCCCCCCCCEECC | 34.41 | 20377248 | |
| 176 | Phosphorylation | NCLDLDNSSLVHTDS CCEECCCCCCCCCHH | 25.39 | 21440633 | |
| 177 | Phosphorylation | CLDLDNSSLVHTDSY CEECCCCCCCCCHHH | 40.44 | 20377248 | |
| 181 | Phosphorylation | DNSSLVHTDSYIQDL CCCCCCCCHHHHHCC | 21.11 | 21440633 | |
| 183 | Phosphorylation | SSLVHTDSYIQDLND CCCCCCHHHHHCCCC | 25.87 | 20377248 | |
| 184 | Phosphorylation | SLVHTDSYIQDLNDD CCCCCHHHHHCCCCC | 12.86 | 20377248 | |
| 200 | Phosphorylation | ILLNKRVSRRSSRIS EEECHHHHHCHHCCE | 26.47 | 24961812 | |
| 203 | Phosphorylation | NKRVSRRSSRISAVT CHHHHHCHHCCEEEE | 23.90 | 19779198 | |
| 204 | Phosphorylation | KRVSRRSSRISAVTA HHHHHCHHCCEEEEE | 31.64 | 28889911 | |
| 207 | Phosphorylation | SRRSSRISAVTATST HHCHHCCEEEEECCH | 18.64 | 28889911 | |
| 210 | Phosphorylation | SSRISAVTATSTTIK HHCCEEEEECCHHHH | 24.76 | 23749301 | |
| 212 | Phosphorylation | RISAVTATSTTIKQR CCEEEEECCHHHHHH | 19.76 | 28889911 | |
| 213 | Phosphorylation | ISAVTATSTTIKQRR CEEEEECCHHHHHHC | 22.53 | 28152593 | |
| 214 | Phosphorylation | SAVTATSTTIKQRRN EEEEECCHHHHHHCC | 28.34 | 21440633 | |
| 215 | Phosphorylation | AVTATSTTIKQRRNT EEEECCHHHHHHCCC | 26.41 | 25752575 | |
| 222 | Phosphorylation | TIKQRRNTQDSNLPN HHHHHCCCCCCCCCC | 31.76 | 17330950 | |
| 225 | Phosphorylation | QRRNTQDSNLPNIPF HHCCCCCCCCCCCCC | 30.37 | 19823750 | |
| 235 | Phosphorylation | PNIPFHASKHSQILP CCCCCCCCCCCCCCC | 23.49 | 22890988 | |
| 236 | Ubiquitination | NIPFHASKHSQILPM CCCCCCCCCCCCCCC | 48.32 | 17644757 | |
| 238 | Phosphorylation | PFHASKHSQILPMDD CCCCCCCCCCCCCCH | 23.74 | 28889911 | |
| 246 | Phosphorylation | QILPMDDSDVIKLAN CCCCCCHHHHEECCC | 29.52 | 30377154 | |
| 257 | Phosphorylation | KLANGDTSMKPNSAT ECCCCCCCCCCCCCC | 29.55 | 21440633 | |
| 259 | Ubiquitination | ANGDTSMKPNSATKI CCCCCCCCCCCCCCC | 40.59 | 23749301 | |
| 262 | Phosphorylation | DTSMKPNSATKISHS CCCCCCCCCCCCCCC | 45.93 | 21440633 | |
| 267 | Phosphorylation | PNSATKISHSMTSLP CCCCCCCCCCCCCCC | 15.86 | 22369663 | |
| 269 | Phosphorylation | SATKISHSMTSLPLH CCCCCCCCCCCCCCC | 19.57 | 22369663 | |
| 271 | Phosphorylation | TKISHSMTSLPLHPL CCCCCCCCCCCCCCC | 30.08 | 22369663 | |
| 272 | Phosphorylation | KISHSMTSLPLHPLP CCCCCCCCCCCCCCC | 21.24 | 22369663 | |
| 282 | Phosphorylation | LHPLPQPSQKSKQYH CCCCCCCCHHCCCEE | 45.02 | 22369663 | |
| 295 | Phosphorylation | YHMISKSTTSLPPEN EEEECCCCCCCCCCC | 24.92 | 28889911 | |
| 296 | Phosphorylation | HMISKSTTSLPPEND EEECCCCCCCCCCCC | 35.04 | 28152593 | |
| 297 | Phosphorylation | MISKSTTSLPPENDH EECCCCCCCCCCCCC | 38.68 | 28889911 | |
| 337 | Ubiquitination | TTAATGLKRSESATA CCCCCCCCCCHHHHH | 56.05 | 17644757 | |
| 339 | Phosphorylation | AATGLKRSESATAEI CCCCCCCCHHHHHHH | 34.02 | 19823750 | |
| 341 | Phosphorylation | TGLKRSESATAEIKK CCCCCCHHHHHHHHH | 31.97 | 19823750 | |
| 343 | Phosphorylation | LKRSESATAEIKKMR CCCCHHHHHHHHHHH | 33.82 | 21440633 | |
| 365 | Phosphorylation | EMKRKRKTFLVDDDR HHHHCCCEEEECCCE | 26.66 | 28889911 | |
| 650 | Ubiquitination | IHDINKAKEDDLQLA HHHHHHCCCCCCCCC | 64.38 | 23749301 | |
| 659 | Phosphorylation | DDLQLADTASIEEQP CCCCCCCCCCHHCCC | 19.39 | 22369663 | |
| 661 | Phosphorylation | LQLADTASIEEQPQT CCCCCCCCHHCCCCC | 32.40 | 22369663 | |
| 668 | Phosphorylation | SIEEQPQTQGPIRTG CHHCCCCCCCCCCCC | 42.02 | 22369663 | |
| 674 | Phosphorylation | QTQGPIRTGTGTVVR CCCCCCCCCCCHHHH | 39.55 | 21126336 | |
| 676 | Phosphorylation | QGPIRTGTGTVVRHF CCCCCCCCCHHHHHH | 29.12 | 27214570 | |
| 762 | Ubiquitination | SVDPLPQKKTQSSYR CCCCCCCCCCCCCCC | 56.71 | 17644757 | |
| 763 | Ubiquitination | VDPLPQKKTQSSYRD CCCCCCCCCCCCCCC | 46.69 | 17644757 | |
| 766 | Phosphorylation | LPQKKTQSSYRDDPN CCCCCCCCCCCCCCC | 34.27 | 30377154 | |
| 768 | Phosphorylation | QKKTQSSYRDDPNQK CCCCCCCCCCCCCCC | 24.25 | 28889911 | |
| 775 | Ubiquitination | YRDDPNQKNYKD--- CCCCCCCCCCCC--- | 69.73 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MSS4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MSS4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MSS4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269; THR-659 ANDSER-661, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-659 AND SER-661, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-222, AND MASSSPECTROMETRY. | |
