AVO2_YEAST - dbPTM
AVO2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AVO2_YEAST
UniProt AC Q04749
Protein Name Target of rapamycin complex 2 subunit AVO2
Gene Name AVO2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 426
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side . Vacuole membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway..
Protein Sequence MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MLKEPSVRLREAI
--CCCCCCHHHHHHH		22.4428889911
219PhosphorylationKKPSSFRTPILNAKA
CCCCCCCCCCCCCEE		16.8121440633
259PhosphorylationPVLPRRISTHTTSGN
CCCCCEEEECCCCCC		16.6030377154
272PhosphorylationGNGGNRRSSITNPVF
CCCCCCCCCCCCCCC		23.9022369663
273PhosphorylationNGGNRRSSITNPVFN
CCCCCCCCCCCCCCC		31.4622369663
275PhosphorylationGNRRSSITNPVFNPR
CCCCCCCCCCCCCCC		35.1019779198
287PhosphorylationNPRKPTLSTDSFSSS
CCCCCCCCCCCCCCC		32.4228889911
290PhosphorylationKPTLSTDSFSSSSNS
CCCCCCCCCCCCCCC		27.4123749301
297PhosphorylationSFSSSSNSSSRLRVN
CCCCCCCCCCCEEEE		31.4728889911
298PhosphorylationFSSSSNSSSRLRVNS
CCCCCCCCCCEEEEE		24.5928132839
299PhosphorylationSSSSNSSSRLRVNSI
CCCCCCCCCEEEEEE		34.8428132839
305PhosphorylationSSRLRVNSINVKTPV
CCCEEEEEEEECCCC		16.8123749301
310PhosphorylationVNSINVKTPVGVSPK
EEEEEECCCCCCCCC		20.9422369663
315PhosphorylationVKTPVGVSPKKELVS
ECCCCCCCCCHHHCC		25.6922369663
328PhosphorylationVSESVRHSATPTSPH
CCHHHHCCCCCCCCC		24.2322369663
330PhosphorylationESVRHSATPTSPHNN
HHHHCCCCCCCCCCC		30.0722369663
332PhosphorylationVRHSATPTSPHNNIA
HHCCCCCCCCCCCEE		51.0022369663
333PhosphorylationRHSATPTSPHNNIAL
HCCCCCCCCCCCEEE		25.9322369663
350PhosphorylationRYLLPNKSNDNVRGD
EEECCCCCCCCCCCC		56.9322369663
358PhosphorylationNDNVRGDSQTATIND
CCCCCCCCCCEEEEC		32.0522369663
360PhosphorylationNVRGDSQTATINDDG
CCCCCCCCEEEECCC		29.7122369663
362PhosphorylationRGDSQTATINDDGGG
CCCCCCEEEECCCCC		24.5722369663
376PhosphorylationGGNGGDATIGMGLRK
CCCCCCCEEECCCCC		23.8522369663
407PhosphorylationGEPRRRVSLLNIPIS
CCCCEEEEEEECCHH		25.9021440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AVO2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AVO2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AVO2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLM1_YEASTSLM1physical
10688190
AVO1_YEASTAVO1physical
12408816
LST8_YEASTLST8physical
12408816
TOR2_YEASTTOR2physical
12408816
SLM1_YEASTSLM1physical
15689497
SLM2_YEASTSLM2physical
15689497
BIT61_YEASTBIT61genetic
14736892
VHR2_YEASTVHR2physical
16554755
RMR1_YEASTRMR1physical
11283351
SLM2_YEASTSLM2physical
11283351
YPK1_YEASTYPK1genetic
17507646
SCS22_YEASTSCS22genetic
20093466
YBQ3_YEASTYBR053Cgenetic
20093466
MBP1_YEASTMBP1genetic
20093466
RAD28_YEASTRAD28genetic
20093466
HMO1_YEASTHMO1genetic
20093466
CRF1_YEASTCRF1genetic
20093466
SPT3_YEASTSPT3genetic
20093466
MTO1_YEASTMTO1genetic
20093466
YOR1_YEASTYOR1genetic
20093466
HXT5_YEASTHXT5genetic
20093466
OYE2_YEASTOYE2genetic
20093466
MNT3_YEASTMNT3genetic
20093466
IF4A_YEASTTIF2genetic
20093466
IML2_YEASTIML2genetic
20093466
PRY3_YEASTPRY3genetic
20093466
YJ24_YEASTKCH1genetic
20093466
DBP7_YEASTDBP7genetic
20093466
YL053_YEASTYLR053Cgenetic
20093466
ERFB_YEASTERF2genetic
20093466
TMA23_YEASTTMA23genetic
20093466
EOS1_YEASTEOS1genetic
20093466
HDA1_YEASTHDA1genetic
20093466
GRE2_YEASTGRE2genetic
20093466
HMI1_YEASTHMI1genetic
20093466
MSH2_YEASTMSH2genetic
20093466
AIM39_YEASTAIM39genetic
20093466
ERV2_YEASTERV2genetic
20093466
HPA2_YEASTHPA2genetic
20093466
YBQ3_YEASTYBR053Cgenetic
27708008
RU1A_YEASTMUD1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
MBP1_YEASTMBP1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
RAD28_YEASTRAD28genetic
27708008
OCA6_YEASTOCA6genetic
27708008
CRF1_YEASTCRF1genetic
27708008
IRC4_YEASTIRC4genetic
27708008
HUR1_YEASTHUR1genetic
27708008
MTO1_YEASTMTO1genetic
27708008
ASK10_YEASTASK10genetic
27708008
YOR1_YEASTYOR1genetic
27708008
MED20_YEASTSRB2genetic
27708008
LAM4_YEASTYHR080Cgenetic
27708008
HXT5_YEASTHXT5genetic
27708008
PRY3_YEASTPRY3genetic
27708008
IF4A_YEASTTIF2genetic
27708008
CYP7_YEASTCPR7genetic
27708008
YJ24_YEASTKCH1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
DBP7_YEASTDBP7genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
ERFB_YEASTERF2genetic
27708008
HDA1_YEASTHDA1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
NTH2_YEASTNTG2genetic
27708008
GRE2_YEASTGRE2genetic
27708008
WTM2_YEASTWTM2genetic
27708008
HPA2_YEASTHPA2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AVO2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; THR-330; THR-332AND SER-350, AND MASS SPECTROMETRY.

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