LAM4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAM4_YEAST
• UniProt AC: P38800
• Protein Name: Membrane-anchored lipid-binding protein LAM4 {ECO:0000303|PubMed:26001273}
• Gene Name: LAM4 {ECO:0000303|PubMed:26001273}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1345
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact sites.
• Protein Description: May be involved in sterol transfer between intracellular membranes..
• Protein Sequence: MTRDSKKKHHWGTAFLRTIGVKRKHKKDRNFLNNTTGENVSTTASAERFRRVGGNPDIPSLLKPETFTESPAKGSQKAAASSLAHSQGVFNIPIVIDPMETNRLEKTNTNLTAGSLKGRFQDGNSNSNSVPSLSVQALEKEKLQSGKREGSSNQAEEKTPDGHDEHTAFETFLSFAHNAVSHIPKINVQDADNGTISRNEPKDRKKNSSNISGALSENSTNNKNTSSTKESDGPFLKNLDNILAASKSSTPSNQQLNTTEAGSKSKPSSLSRLAFGNLKGHIHSNSHSSSNAISGDDTSLDDTRKMTDDMARKVVFEPIRHSHDKPTPGVGNLKLEHFDDSQATLEGLEAMSAESLPEADHLDSRGPVQQSNLERKTVPSKWSVVSSSTTDGVKPRRRAKSMISAMADKQNTSSDVLQDCKKRLSFNSSNGLTNNDPEYEDREPREMSKKFLNRRSFSPGSISMGMKVLPSTALKYSLNKVKNSTDIASTIIPRPSMSNGRPSSGLRRSSSKSFSSTPVNIIEPSEENGRQSSIRIKGVEYASEKKDAEFHAIFKDSGVSPNERLILDHSCALSRDILLQGRMYISDQHIGFYSNILGWVSTVFIPFKTIVQIEKRATAGIFPNGIVIDTLHTKYTFASFTSRDATYDLITEVWNQIILGKRFRSNSNNTNSSSNSISDDENDDYDDDYDDYGDDDDDLYDNSNNISDSTDMTSSVSIGKPEDLPMPLQTDTPYGTGIPPLGPKIHSPTETVYKPAPNEKLVNESTIHASLGRVVNILFGKDVSYIMAILKAQKNSDISPIPVLVDSPTVSEGKKRDYSYVKTTPGAIGPGKTKCMITETIQHFNLEEYVQVLQTTKTPDVPSGNSFYVRTVYLLSWANNNETKLKLYVSVEWTGKSLIKSPIEKGTFDGVTDATKILVEELGNILTRSATKRKRSSKENTVTVSTLPKMEPSSHAPTEPDIQKDKDDSIIRENENIPAPLGTVVQLLFGSNTEYMQKVITRDKNNVNVETIPKFTPSLVEGGSRHYEYTKKLNNSIGPKQTKCLLTESIEHMDINNYVLVTQTTKTPDVPSGSNFAVESKIFLFWGQHDTTNMTVITKINWTSKSFLKGAIEKGSVEGQKVSVDYMLSELRDIISRAKSKKPVKKVMKSHDKHRPFHSKVEQKSSESRKSDDNKDILTHILDFVQNNFSSEIFMNKLLSPQKLFLILGLTIMLFWSPRLHVFQEKNNLQIIKPGRLLIDGQEYNYVPSFGTLYNSYENAISSKKKRENVNYARDKSPIVGRESDIWDWISNRGSAISPRGRAMLRNDDEHKLQQLSESIKITEMQLNHMKTMLDNIERDANDLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	TGENVSTTASAERFR CCCCCCCHHHHHHHH		23749301
45	Phosphorylation	ENVSTTASAERFRRV CCCCCHHHHHHHHHC		23749301
60	Phosphorylation	GGNPDIPSLLKPETF CCCCCCHHHCCCCCC		28889911
66	Phosphorylation	PSLLKPETFTESPAK HHHCCCCCCCCCCCC		28152593
68	Phosphorylation	LLKPETFTESPAKGS HCCCCCCCCCCCCCC		28889911
70	Phosphorylation	KPETFTESPAKGSQK CCCCCCCCCCCCCHH		23749301
81	Phosphorylation	GSQKAAASSLAHSQG CCHHHHHHHHHHCCC		21440633
82	Phosphorylation	SQKAAASSLAHSQGV CHHHHHHHHHHCCCC		21440633
86	Phosphorylation	AASSLAHSQGVFNIP HHHHHHHCCCCCCCC		21440633
107	Phosphorylation	ETNRLEKTNTNLTAG CCCCCCCCCCCCCCC		23749301
109	Phosphorylation	NRLEKTNTNLTAGSL CCCCCCCCCCCCCEE		22369663
112	Phosphorylation	EKTNTNLTAGSLKGR CCCCCCCCCCEEECC		22369663
115	Phosphorylation	NTNLTAGSLKGRFQD CCCCCCCEEECCCCC		22369663
125	Phosphorylation	GRFQDGNSNSNSVPS CCCCCCCCCCCCCCE		22369663
127	Phosphorylation	FQDGNSNSNSVPSLS CCCCCCCCCCCCEEE		22369663
129	Phosphorylation	DGNSNSNSVPSLSVQ CCCCCCCCCCEEEHH		22369663
132	Phosphorylation	SNSNSVPSLSVQALE CCCCCCCEEEHHHHH		22369663
134	Phosphorylation	SNSVPSLSVQALEKE CCCCCEEEHHHHHHH		22369663
208	Phosphorylation	PKDRKKNSSNISGAL CCCCCCCCCCCCHHC		28889911
209	Phosphorylation	KDRKKNSSNISGALS CCCCCCCCCCCHHCC		28889911
219	Phosphorylation	SGALSENSTNNKNTS CHHCCCCCCCCCCCC		28889911
249	Phosphorylation	ILAASKSSTPSNQQL HHHHCCCCCCCCCCC		28889911
250	Phosphorylation	LAASKSSTPSNQQLN HHHCCCCCCCCCCCC		29136822
252	Phosphorylation	ASKSSTPSNQQLNTT HCCCCCCCCCCCCCC		29136822
258	Phosphorylation	PSNQQLNTTEAGSKS CCCCCCCCCCCCCCC		29136822
259	Phosphorylation	SNQQLNTTEAGSKSK CCCCCCCCCCCCCCC		29136822
263	Phosphorylation	LNTTEAGSKSKPSSL CCCCCCCCCCCCCHH		29136822
265	Phosphorylation	TTEAGSKSKPSSLSR CCCCCCCCCCCHHHH		21440633
268	Phosphorylation	AGSKSKPSSLSRLAF CCCCCCCCHHHHHHH		21440633
269	Phosphorylation	GSKSKPSSLSRLAFG CCCCCCCHHHHHHHC		21440633
271	Phosphorylation	KSKPSSLSRLAFGNL CCCCCHHHHHHHCCC		19823750
284	Phosphorylation	NLKGHIHSNSHSSSN CCCCEECCCCCCCCC		29136822
286	Phosphorylation	KGHIHSNSHSSSNAI CCEECCCCCCCCCCC		29136822
290	Phosphorylation	HSNSHSSSNAISGDD CCCCCCCCCCCCCCC		21551504
294	Phosphorylation	HSSSNAISGDDTSLD CCCCCCCCCCCCCHH		24961812
298	Phosphorylation	NAISGDDTSLDDTRK CCCCCCCCCHHHHHH		19779198
299	Phosphorylation	AISGDDTSLDDTRKM CCCCCCCCHHHHHHC		29136822
322	Phosphorylation	VFEPIRHSHDKPTPG HHCCCCCCCCCCCCC		20377248
327	Phosphorylation	RHSHDKPTPGVGNLK CCCCCCCCCCCCCEE		21551504
352	Phosphorylation	LEGLEAMSAESLPEA HHHHHHHCCCCCCCC		19779198
355	Phosphorylation	LEAMSAESLPEADHL HHHHCCCCCCCCCCC		21440633
364	Phosphorylation	PEADHLDSRGPVQQS CCCCCCCCCCCCCCC		24961812
371	Phosphorylation	SRGPVQQSNLERKTV CCCCCCCCCCCCCCC		24961812
401	Phosphorylation	KPRRRAKSMISAMAD CCHHHHHHHHHHHHH		28152593
413	Phosphorylation	MADKQNTSSDVLQDC HHHCCCCCHHHHHHH		28889911
425	Phosphorylation	QDCKKRLSFNSSNGL HHHHHHHCCCCCCCC		29136822
428	Phosphorylation	KKRLSFNSSNGLTNN HHHHCCCCCCCCCCC		21440633
429	Phosphorylation	KRLSFNSSNGLTNND HHHCCCCCCCCCCCC		29136822
433	Phosphorylation	FNSSNGLTNNDPEYE CCCCCCCCCCCCCCC		29136822
458	Phosphorylation	FLNRRSFSPGSISMG HHHCCCCCCCCCHHC		21082442
496	Phosphorylation	STIIPRPSMSNGRPS CCCCCCCCCCCCCCC		27017623
498	Phosphorylation	IIPRPSMSNGRPSSG CCCCCCCCCCCCCCC		27017623
504	Phosphorylation	MSNGRPSSGLRRSSS CCCCCCCCCCCCCCC		27017623
513	Phosphorylation	LRRSSSKSFSSTPVN CCCCCCCCCCCCCCE		28889911
516	Phosphorylation	SSSKSFSSTPVNIIE CCCCCCCCCCCEEEC		28889911
747	Phosphorylation	PLGPKIHSPTETVYK CCCCCCCCCCCCEEC		17330950
834	Ubiquitination	AIGPGKTKCMITETI CCCCCCCEEEEECCC		24961812
937	Phosphorylation	ATKRKRSSKENTVTV CHHCCCCCCCCEEEE		19779198
1049	Phosphorylation	TKCLLTESIEHMDIN CCEEEECCEEECCCC		21551504

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAM4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAM4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAM4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSB1_YEAST	SSB1	physical	19536198
SWI5_YEAST	SWI5	physical	22875988
GLU2B_YEAST	GTB1	physical	22875988
ZIP1_YEAST	ZIP1	physical	22875988
HDA2_YEAST	HDA2	physical	22875988
SHE9_YEAST	SHE9	physical	22875988
VPS60_YEAST	VPS60	physical	22875988
SPC25_YEAST	SPC25	physical	22875988
TSC11_YEAST	TSC11	physical	22875988
GCN20_YEAST	GCN20	physical	22875988
MED3_YEAST	PGD1	physical	22875988
MPS2_YEAST	MPS2	physical	22875988
KXD1_YEAST	KXD1	physical	22875988
MAD1_YEAST	MAD1	physical	22875988
ITC1_YEAST	ITC1	physical	22875988
TIP20_YEAST	TIP20	physical	22875988
NNF2_YEAST	NNF2	physical	22875988
YJE9_YEAST	YJL049W	physical	22875988
HMS2_YEAST	HMS2	physical	22875988
HSK3_YEAST	HSK3	physical	22875988
NTR2_YEAST	NTR2	physical	22875988
DYHC_YEAST	DYN1	physical	22875988
DAD2_YEAST	DAD2	physical	22875988
MMR1_YEAST	MMR1	physical	22875988
BDF1_YEAST	BDF1	physical	22875988
BUL2_YEAST	BUL2	physical	22875988
STV1_YEAST	STV1	physical	22875988
END3_YEAST	END3	physical	22875988
PRS6A_YEAST	RPT5	physical	22875988
LIS1_YEAST	PAC1	physical	22875988
HPH1_YEAST	FRT1	physical	22875988
KAR3_YEAST	KAR3	physical	22875988
YP174_YEAST	YPR174C	physical	22875988
MPS1_YEAST	MPS1	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
YSP2_YEAST	YSP2	genetic	28774891
YPK1_YEAST	YPK1	genetic	28774891

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.