YSP2_YEAST - dbPTM
YSP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YSP2_YEAST
UniProt AC Q06681
Protein Name Membrane-anchored lipid-binding protein YSP2 {ECO:0000303|PubMed:26001273}
Gene Name YSP2 {ECO:0000303|PubMed:16962064}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1438
Subcellular Localization Mitochondrion membrane
Single-pass membrane protein . Endoplasmic reticulum membrane
Single-pass membrane protein . Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact
Protein Description Involved in induction of programmed cell death in response to reactive oxygen species (ROS). [PubMed: 16962064 May be involved in sterol transfer between intracellular membranes]
Protein Sequence MRDEATRKKRSFSDGHFFKKLKLMSRKKQPVMERSKTTRTRKESTNSAAKSSLSLRRANNGRKTIAKRRVLTDIGSTNEGVAGNSGSNSPAQYSHTPHFSDSIPPLPLELPDIVSIRSSRSHISNKSNKNKHGIDLTFIPRRSLQNSKAGLKKPNTSPQGYFNIPVTIDRASEKVKHTDTKNTFNSSSSENERPVLSILQKDDSQSSSHPAIDSMSAPNNINNNNDIENSSNSLFDTILSIAHSAISHVPKISALNTEIQREFSHSGESHTGSTRHPYFHIHHAQQQHPLSQQQGPLPVSENANQNPNDTVLIHSPSANTAHRSSSFLRHLDYLLSPTSGPASDKHTQVEEGDDEEELSPLSKAFLSPSTQLVPTNTSTTPLSGSLTPNNRNVNANSNSETENDNDRDDRSNVGKVKFQPLKVHEPAISTFGKGNLTLEAVAGSSDIDNTTIDLDENNTNNNPNASSTNLSHISKSNVNNNLGPKELNTSYRNSTYIDMARFENSQSNLSSHRARSKTLPANKALENAVGDEGNSKRNSRYSSYSNDMAFDDADERKFRSMSKKFLNRRSFSPSNLGNKVIPGINLRNSFNKNRNSSSDFFSTNQGQQMPRTSTAGSGNIHAIMGLDSGNDDFKLEGIEYASEKKNSEFHTLFKDCDINPNEKLIVDHSCALSRDILLQGRMYISDAHIGFFSNILGWVSTVFIPFKEIVQIEKKTTAGIFPNGIVIDTLHTKYIFASFMSRDATFDLITDVWNQIILGKKYRNGFGNNDDGTISDSSSAFFDDSDDNDDDGDLDDDDPDINSTDMTSSDDIDADVFNESNDLGKNQKSTNYLLGPNKHSPTTADFKPSNNDHLVIEANINAPLGKVVNLLYGEDVSYYERILKAQKNFEISPIPNNFLTKKIRDYAYTKPLSGSIGPSKTKCLITDTLEHYDLEDYVKVLSITKNPDVPSGNIFSVKTVFLFSWDKNNSTKLTVYNSVDWTGKSWIKSMIEKGTFDGVADTTKIMISEIKKILSDEDSNINSKHQASNNESEEEIINLPTIGPPVHDPTEPDFQKGKDDTVIDEKINIPVPLGTVFSLLYGDDTSYIKKIIENQNNFNVCDIPKFVNNAREITYTKKLNNSFGPKQTKCIVTETIEHMDLNSFFMVKQIVRSPDVPYGSSFSVHTRFFYSWGDHNTTNMKVVTNVVWTGKSMLKGTIEKGSIDGQRSSTKQLVDDLKKIISNASSTKKKSRRRGKTVNKRKSSPSTIKNEKNEENFEDTSTKNSFFSAFSMLQQVNITSVQGIMTIISFFICLIFFFRLLFHSKNTSNIQIITPGTILINGNEYNYVPNFKTLYHVYEDNIIKDARRKDSNKNNIVTDTEGLIWDWLIDRGNGTVQNSVLSNHIKESNNKKVKLVNGVSDHKIQQLVESIKITELQLQEMKELLAQTDNTSATNQLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationEATRKKRSFSDGHFF
HHHHHHCCCCCCHHH		37.6728889911
13PhosphorylationTRKKRSFSDGHFFKK
HHHHCCCCCCHHHHH		43.8817330950
44PhosphorylationTTRTRKESTNSAAKS
CCCCHHHHHHHHHHH		35.6024961812
45PhosphorylationTRTRKESTNSAAKSS
CCCHHHHHHHHHHHH		33.9924961812
47PhosphorylationTRKESTNSAAKSSLS
CHHHHHHHHHHHHHH		29.6824961812
51PhosphorylationSTNSAAKSSLSLRRA
HHHHHHHHHHHHHHH		31.6122369663
52PhosphorylationTNSAAKSSLSLRRAN
HHHHHHHHHHHHHHH		22.6722369663
54PhosphorylationSAAKSSLSLRRANNG
HHHHHHHHHHHHHCC		23.0622369663
87PhosphorylationGVAGNSGSNSPAQYS
CCCCCCCCCCCCCCC		33.6727738172
137PhosphorylationNKHGIDLTFIPRRSL
CCCCCCCEEEEHHHH		18.7719795423
143PhosphorylationLTFIPRRSLQNSKAG
CEEEEHHHHCCCCCC		35.2728889911
147PhosphorylationPRRSLQNSKAGLKKP
EHHHHCCCCCCCCCC		15.7719795423
156PhosphorylationAGLKKPNTSPQGYFN
CCCCCCCCCCCCCCC		50.7628889911
157PhosphorylationGLKKPNTSPQGYFNI
CCCCCCCCCCCCCCC		23.1321440633
161PhosphorylationPNTSPQGYFNIPVTI
CCCCCCCCCCCCEEE		6.5530377154
167PhosphorylationGYFNIPVTIDRASEK
CCCCCCEEEECHHHH		16.2921440633
172PhosphorylationPVTIDRASEKVKHTD
CEEEECHHHHCCCCC		38.5521440633
183PhosphorylationKHTDTKNTFNSSSSE
CCCCCCCCCCCCCCC		26.2520377248
186PhosphorylationDTKNTFNSSSSENER
CCCCCCCCCCCCCCC		27.6622369663
187PhosphorylationTKNTFNSSSSENERP
CCCCCCCCCCCCCCC		38.7022369663
188PhosphorylationKNTFNSSSSENERPV
CCCCCCCCCCCCCCC		41.3020377248
189PhosphorylationNTFNSSSSENERPVL
CCCCCCCCCCCCCCE		46.5220377248
197PhosphorylationENERPVLSILQKDDS
CCCCCCEEEEECCCC		22.8322369663
326PhosphorylationNTAHRSSSFLRHLDY
CCCCCCHHHHHHHHH		29.5521440633
343PhosphorylationSPTSGPASDKHTQVE
CCCCCCCCCCCCCCC		50.7728889911
345UbiquitinationTSGPASDKHTQVEEG
CCCCCCCCCCCCCCC		46.1617644757
359PhosphorylationGDDEEELSPLSKAFL
CCCHHHHCHHHHHHC		27.3725521595
362PhosphorylationEEELSPLSKAFLSPS
HHHHCHHHHHHCCCC		25.8929688323
380PhosphorylationVPTNTSTTPLSGSLT
CCCCCCCCCCCCCCC		23.2323749301
383PhosphorylationNTSTTPLSGSLTPNN
CCCCCCCCCCCCCCC		27.7827017623
385PhosphorylationSTTPLSGSLTPNNRN
CCCCCCCCCCCCCCC		26.2027017623
387PhosphorylationTPLSGSLTPNNRNVN
CCCCCCCCCCCCCCC		26.1823749301
397PhosphorylationNRNVNANSNSETEND
CCCCCCCCCCCCCCC		39.0417563356
399PhosphorylationNVNANSNSETENDND
CCCCCCCCCCCCCCC		45.7917563356
401PhosphorylationNANSNSETENDNDRD
CCCCCCCCCCCCCCC		39.6528889911
411PhosphorylationDNDRDDRSNVGKVKF
CCCCCCCCCCCCEEE		42.7525005228
485UbiquitinationVNNNLGPKELNTSYR
CCCCCCHHHCCHHHC		73.3823749301
494PhosphorylationLNTSYRNSTYIDMAR
CCHHHCCCCEEEHHH		17.3727017623
495PhosphorylationNTSYRNSTYIDMARF
CHHHCCCCEEEHHHH		28.2227017623
505PhosphorylationDMARFENSQSNLSSH
EHHHHCCCCCCHHHH		27.9922369663
507PhosphorylationARFENSQSNLSSHRA
HHHCCCCCCHHHHHH		39.2924909858
510PhosphorylationENSQSNLSSHRARSK
CCCCCCHHHHHHHHC		28.4823749301
511PhosphorylationNSQSNLSSHRARSKT
CCCCCHHHHHHHHCC		21.8422369663
518PhosphorylationSHRARSKTLPANKAL
HHHHHHCCCCHHHHH		38.9423749301
535PhosphorylationAVGDEGNSKRNSRYS
HHCCCCCCCCCCCCC		43.8022369663
536UbiquitinationVGDEGNSKRNSRYSS
HCCCCCCCCCCCCCC		60.6523749301
539PhosphorylationEGNSKRNSRYSSYSN
CCCCCCCCCCCCCCC		36.3124961812
541PhosphorylationNSKRNSRYSSYSNDM
CCCCCCCCCCCCCCC		11.2024961812
542PhosphorylationSKRNSRYSSYSNDMA
CCCCCCCCCCCCCCC		22.9924961812
543PhosphorylationKRNSRYSSYSNDMAF
CCCCCCCCCCCCCCC		24.5223749301
544PhosphorylationRNSRYSSYSNDMAFD
CCCCCCCCCCCCCCC		12.9324961812
545PhosphorylationNSRYSSYSNDMAFDD
CCCCCCCCCCCCCCC		28.4423749301
557UbiquitinationFDDADERKFRSMSKK
CCCHHHHHHHHHHHH		42.9817644757
570PhosphorylationKKFLNRRSFSPSNLG
HHHHHCCCCCHHHCC		27.1719684113
572PhosphorylationFLNRRSFSPSNLGNK
HHHCCCCCHHHCCCC		28.7622369663
574PhosphorylationNRRSFSPSNLGNKVI
HCCCCCHHHCCCCCC		43.4122369663
579UbiquitinationSPSNLGNKVIPGINL
CHHHCCCCCCCCCCC		39.4817644757
589PhosphorylationPGINLRNSFNKNRNS
CCCCCCCCCCCCCCC		24.6228152593
596PhosphorylationSFNKNRNSSSDFFST
CCCCCCCCCCCCCCC		28.1628152593
597PhosphorylationFNKNRNSSSDFFSTN
CCCCCCCCCCCCCCC		37.1621082442
598PhosphorylationNKNRNSSSDFFSTNQ
CCCCCCCCCCCCCCC		37.9521440633
612PhosphorylationQGQQMPRTSTAGSGN
CCCCCCCCCCCCCCC		25.2619779198
613PhosphorylationGQQMPRTSTAGSGNI
CCCCCCCCCCCCCCE		19.9619779198
614PhosphorylationQQMPRTSTAGSGNIH
CCCCCCCCCCCCCEE		34.1319779198
617PhosphorylationPRTSTAGSGNIHAIM
CCCCCCCCCCEEEEE		26.6328889911
663UbiquitinationCDINPNEKLIVDHSC
CCCCCCCCEEEECCH		50.5917644757
825UbiquitinationNESNDLGKNQKSTNY
CCCCCCCCCCCCCCC		64.6022817900
828UbiquitinationNDLGKNQKSTNYLLG
CCCCCCCCCCCCCCC		69.5123749301
829PhosphorylationDLGKNQKSTNYLLGP
CCCCCCCCCCCCCCC		16.4821551504
830PhosphorylationLGKNQKSTNYLLGPN
CCCCCCCCCCCCCCC		34.6121440633
900PhosphorylationPIPNNFLTKKIRDYA
CCCCCCHHHHHHHHC		26.5928889911
910UbiquitinationIRDYAYTKPLSGSIG
HHHHCCCCCCCCCCC		31.1417644757
920UbiquitinationSGSIGPSKTKCLITD
CCCCCCCCCEEEEEC		55.9517644757
945UbiquitinationVKVLSITKNPDVPSG
EEEEEECCCCCCCCC		65.8924961812
993UbiquitinationWIKSMIEKGTFDGVA
HHHHHHHHCCCCCCC		52.9423749301
1028PhosphorylationINSKHQASNNESEEE
CCHHCCCCCCCCHHH		33.3520377248
1032PhosphorylationHQASNNESEEEIINL
CCCCCCCCHHHHHCC		53.0521440633
1089UbiquitinationGDDTSYIKKIIENQN
CCCHHHHHHHHHCCC		29.6817644757
1090UbiquitinationDDTSYIKKIIENQNN
CCHHHHHHHHHCCCC		39.0817644757
1105UbiquitinationFNVCDIPKFVNNARE
CCCCCHHHHHCCCCE		63.3817644757
1122PhosphorylationYTKKLNNSFGPKQTK
EEECCCCCCCCCCCE		30.4319823750
1128PhosphorylationNSFGPKQTKCIVTET
CCCCCCCCEEEEECE		33.7319823750
1163PhosphorylationVPYGSSFSVHTRFFY
CCCCCCEEEEEEEEE		18.2230377154
1225PhosphorylationKKIISNASSTKKKSR
HHHHHCCCCHHHHHH		42.6730377154
1306N-linked_GlycosylationRLLFHSKNTSNIQII
HHHHCCCCCCCCEEE		52.32-
1373N-linked_GlycosylationDWLIDRGNGTVQNSV
HHHHHCCCCCCCHHH		43.80-
1428PhosphorylationMKELLAQTDNTSATN
HHHHHHCCCCCHHHH		26.1329136822
1430N-linked_GlycosylationELLAQTDNTSATNQL
HHHHCCCCCHHHHHC		39.04-
1431PhosphorylationLLAQTDNTSATNQLL
HHHCCCCCHHHHHCC		23.6529136822
1432PhosphorylationLAQTDNTSATNQLL-
HHCCCCCHHHHHCC-		39.0729136822
1434PhosphorylationQTDNTSATNQLL---
CCCCCHHHHHCC---		24.2229136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YSP2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YSP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YSP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TMA20_YEASTTMA20physical
10688190
SLM1_YEASTSLM1physical
10688190
GLU2B_YEASTGTB1physical
22875988
BDF1_YEASTBDF1physical
22875988
TDA1_YEASTTDA1genetic
27708008
OCA1_YEASTOCA1genetic
27708008
TECR_YEASTTSC13genetic
27708008
ACT_YEASTACT1genetic
27708008
CAP_YEASTSRV2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
HIR1_YEASTHIR1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
BAP3_YEASTBAP3genetic
27708008
AIM11_YEASTAIM11genetic
27708008
RAD4_YEASTRAD4genetic
27708008
TFS2_YEASTDST1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
PEF1_YEASTPEF1genetic
27708008
INM1_YEASTINM1genetic
27708008
MPCP_YEASTMIR1genetic
27708008
HAP4_YEASTHAP4genetic
27708008
ELF1_YEASTELF1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ERG3_YEASTERG3genetic
27708008
OCA2_YEASTOCA2genetic
27708008
MKT1_YEASTMKT1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
HAP5_YEASTHAP5genetic
27708008
RAD1_YEASTRAD1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
YPK1_YEASTYPK1genetic
28774891
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YSP2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188; SER-572; SER-597;SER-598 AND SER-617, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397 AND SER-399, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.

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