MPS2_YEAST - dbPTM
MPS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPS2_YEAST
UniProt AC P53159
Protein Name Monopolar spindle protein 2
Gene Name MPS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 387
Subcellular Localization Nucleus membrane
Single-pass membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body .
Protein Description Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication..
Protein Sequence MSNGAFDAIFEYAWGQIDKPISGDFIYGKDLPKLIEIIENIFQKAQKSGSYELRLPLFSEINKDLFRTFSNTKTFFKIHKEEFDDIFFNLVNHPLREILENAFIGVDSIPSDFIVSMNLNSPSKFLVENKNKNTEGAGISTPRKKLTESPIKLLSRNNIGKALEVQVEELKRELTAKQSLLQENERQVSELKIRLETYQEKYASIQQRFSDLQKARQVEDNQNSSRTSDPGSPLVTGIDQKAILEEFRRRLQRQTDTISFLKDQIRRERGLNCSNDKVSHSKRKHATTDGDGTFKNFISAVPSNIWVKATIRIIVCFALLAGVLPYIRKYVYAHDTPSQNSRLQLSWWENSGILSKIVWFFEDQTDLETEYRSNANVDDAYSRVFGI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationPISGDFIYGKDLPKL
CCCCCEECCCCHHHH		20.3728889911
116PhosphorylationIPSDFIVSMNLNSPS
CCCCEEEEECCCCCC		9.3521700874
121PhosphorylationIVSMNLNSPSKFLVE
EEEECCCCCCCEEEE		33.4421700874
123PhosphorylationSMNLNSPSKFLVENK
EECCCCCCCEEEECC		35.5421700874
134PhosphorylationVENKNKNTEGAGIST
EECCCCCCCCCCCCC		37.0919823750
140PhosphorylationNTEGAGISTPRKKLT
CCCCCCCCCCCHHCC		31.2928152593
141PhosphorylationTEGAGISTPRKKLTE
CCCCCCCCCCHHCCC		25.7825704821
147PhosphorylationSTPRKKLTESPIKLL
CCCCHHCCCCHHHHH		43.2119823750
149PhosphorylationPRKKLTESPIKLLSR
CCHHCCCCHHHHHHC		27.0419823750
155PhosphorylationESPIKLLSRNNIGKA
CCHHHHHHCCCCCHH		43.3221440633
189PhosphorylationQENERQVSELKIRLE
HHCHHHHHHHHHHHH		28.9528889911
224PhosphorylationQVEDNQNSSRTSDPG
HHCCCCCCCCCCCCC		16.0723749301
225PhosphorylationVEDNQNSSRTSDPGS
HCCCCCCCCCCCCCC		47.3121440633
227PhosphorylationDNQNSSRTSDPGSPL
CCCCCCCCCCCCCCC		39.1521440633
228PhosphorylationNQNSSRTSDPGSPLV
CCCCCCCCCCCCCCC		40.4721440633
232PhosphorylationSRTSDPGSPLVTGID
CCCCCCCCCCCCCCC		22.0528152593
236PhosphorylationDPGSPLVTGIDQKAI
CCCCCCCCCCCHHHH		35.7819823750
274PhosphorylationRERGLNCSNDKVSHS
HHHCCCCCCCCCCCC		47.1728889911
281PhosphorylationSNDKVSHSKRKHATT
CCCCCCCCCCCCCCC		27.0121700874
288PhosphorylationSKRKHATTDGDGTFK
CCCCCCCCCCCCCHH		38.4821700874
299PhosphorylationGTFKNFISAVPSNIW
CCHHHHHHCCCCCHH		21.0521700874
336PhosphorylationKYVYAHDTPSQNSRL
HHHHHCCCCCCCCCE		18.2525371407
338PhosphorylationVYAHDTPSQNSRLQL
HHHCCCCCCCCCEEE		44.0525371407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseSSM4P40318
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPC24_YEASTSPC24physical
11952896
BBP1_YEASTBBP1physical
10654940
BBP1_YEASTBBP1physical
12917332
BBP1_YEASTBBP1physical
11952896
SPC24_YEASTSPC24physical
12917332
AF9_YEASTYAF9physical
12917332
AF9_YEASTYAF9physical
11952896
SPC24_YEASTSPC24physical
11087867
CUE1_YEASTCUE1genetic
12399372
UBC6_YEASTUBC6genetic
12399372
UBC7_YEASTUBC7genetic
12399372
MPS3_YEASTMPS3physical
16923827
BBP1_YEASTBBP1genetic
10654940
NBP1_YEASTNBP1genetic
16436507
ECM13_YEASTECM13physical
17634282
ICS2_YEASTICS2physical
17634282
ADY3_YEASTADY3physical
17634282
SUM1_YEASTSUM1physical
17634282
VHR1_YEASTVHR1physical
17634282
HAP4_YEASTHAP4physical
17634282
MMR1_YEASTMMR1physical
17634282
YM01_YEASTYMR111Cphysical
17634282
SMY2_YEASTSMY2genetic
19571182
EAP1_YEASTEAP1genetic
19571182
BFR1_YEASTBFR1genetic
19571182
SC160_YEASTSCP160genetic
19571182
GBLP_YEASTASC1genetic
19571182
POM34_YEASTPOM34genetic
19571182
PO152_YEASTPOM152genetic
19571182
STE24_YEASTSTE24physical
16093310
DOA10_YEASTSSM4genetic
16437165
PO152_YEASTPOM152genetic
20713690
COPD_YEASTRET2physical
22940862
MAD1_YEASTMAD1physical
22875988
LAM4_YEASTYHR080Cphysical
22875988
RE107_YEASTREC107physical
22875988
NNF1_YEASTNNF1physical
22875988
HSK3_YEASTHSK3physical
22875988
SRN2_YEASTSRN2physical
22875988
STB2_YEASTSTB2physical
22875988
STV1_YEASTSTV1physical
22875988
END3_YEASTEND3physical
22875988
NUF2_YEASTNUF2physical
22875988
TBP6_YEASTYTA6physical
22875988
GYP5_YEASTGYP5physical
22875988
BBP1_YEASTBBP1physical
22875988
RLF2_YEASTRLF2physical
22875988
BLI1_YEASTBLI1physical
22875988
AF9_YEASTYAF9physical
22875988
SPC24_YEASTSPC24physical
22875988
MPS2_YEASTMPS2physical
20139001
BBP1_YEASTBBP1physical
20139001
SMY2_YEASTSMY2genetic
26419396
BBP1_YEASTBBP1physical
28356353
MPS3_YEASTMPS3physical
28356353
SEC66_YEASTSEC66genetic
26510791
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-27, AND MASSSPECTROMETRY.

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