BBP1_YEAST - dbPTM
BBP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BBP1_YEAST
UniProt AC Q12365
Protein Name Spindle pole component BBP1
Gene Name BBP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 385
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Associates with the periphary of the central plaque.
Protein Description Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression..
Protein Sequence MNQEDNTGGGGIFGLFKWTKDALFGTDISPSMKYKDQEERRDRSRYAQDDTNFSMKFGNDSNRRSTNLSRSNSWSGLDSTLHRKYELLPEYNENGFNSIVNGDHHSKERIRSLRSPAPIVPREPLRNEPTDTFGHRLHTKRRTINELSNSQIPFIPPQEDDPLLSKLFNKDGVNEVRRSPYKLSVKDIPGKFPSPLTKRDEIDNYYVRDEDACHKNREYKKAYFDLFAQMDLNSRDLEDLCEDVREQREQFHRNEQTYKQAYEEMRAELVNELKKSKTLFENYYSLGQKYKSLKKVLDQTISHEAELATSRERLYQEEDLKNFEIQTLKQRLSDLELKYTNLQIEKDMQRDNYESEIHDLLLQLSLRNNERKDTSAGSNIFSTGQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MNQEDNTGGGGIFG
-CCCCCCCCCCCCCH		49.9128152593
19PhosphorylationIFGLFKWTKDALFGT
CCHHHHCCHHHHCCC		21.4528889911
26PhosphorylationTKDALFGTDISPSMK
CHHHHCCCCCCCCCC		23.8722369663
29PhosphorylationALFGTDISPSMKYKD
HHCCCCCCCCCCCCC		17.4622369663
31PhosphorylationFGTDISPSMKYKDQE
CCCCCCCCCCCCCHH		22.5522369663
51PhosphorylationSRYAQDDTNFSMKFG
HHHCCCCCCCCCCCC		46.5921700874
54PhosphorylationAQDDTNFSMKFGNDS
CCCCCCCCCCCCCCC		24.1128889911
61PhosphorylationSMKFGNDSNRRSTNL
CCCCCCCCCCCCCCC		35.9125704821
65PhosphorylationGNDSNRRSTNLSRSN
CCCCCCCCCCCCCCC		20.5722369663
66PhosphorylationNDSNRRSTNLSRSNS
CCCCCCCCCCCCCCC		38.0622369663
69PhosphorylationNRRSTNLSRSNSWSG
CCCCCCCCCCCCCCC		35.4122369663
71PhosphorylationRSTNLSRSNSWSGLD
CCCCCCCCCCCCCHH		31.6622369663
73PhosphorylationTNLSRSNSWSGLDST
CCCCCCCCCCCHHHH		24.7022369663
75PhosphorylationLSRSNSWSGLDSTLH
CCCCCCCCCHHHHHH		29.3322369663
98PhosphorylationYNENGFNSIVNGDHH
HCCCCCHHHCCCCCC		26.1721551504
106PhosphorylationIVNGDHHSKERIRSL
HCCCCCCCHHHHHHC		32.5621440633
112PhosphorylationHSKERIRSLRSPAPI
CCHHHHHHCCCCCCC		26.2628889911
115PhosphorylationERIRSLRSPAPIVPR
HHHHHCCCCCCCCCC		30.6117330950
143PhosphorylationRLHTKRRTINELSNS
HHHHCCCCHHHHHCC		31.9921440633
148PhosphorylationRRTINELSNSQIPFI
CCCHHHHHCCCCCCC		28.4027017623
150PhosphorylationTINELSNSQIPFIPP
CHHHHHCCCCCCCCC		26.5527017623
179PhosphorylationGVNEVRRSPYKLSVK
CCCCHHCCCCCCCCC		23.2425521595
181PhosphorylationNEVRRSPYKLSVKDI
CCHHCCCCCCCCCCC		26.3028889911
191AcetylationSVKDIPGKFPSPLTK
CCCCCCCCCCCCCCC		49.0724489116
194PhosphorylationDIPGKFPSPLTKRDE
CCCCCCCCCCCCHHH		35.3625521595
197PhosphorylationGKFPSPLTKRDEIDN
CCCCCCCCCHHHCCC		27.6725521595
205PhosphorylationKRDEIDNYYVRDEDA
CHHHCCCEEECCHHH		10.2921700874
206PhosphorylationRDEIDNYYVRDEDAC
HHHCCCEEECCHHHC		8.6821700874
234PhosphorylationFAQMDLNSRDLEDLC
HHHCCCCCCCHHHHH		34.1719779198
309PhosphorylationSHEAELATSRERLYQ
CHHHHHHHHHHHHHC		40.7321700874
310PhosphorylationHEAELATSRERLYQE
HHHHHHHHHHHHHCH		26.9121440633
333PhosphorylationQTLKQRLSDLELKYT
HHHHHHHHHHHHHHH		42.1928889911
374PhosphorylationRNNERKDTSAGSNIF
HCCCCCCCCCCCCCC		24.4220377248
375PhosphorylationNNERKDTSAGSNIFS
CCCCCCCCCCCCCCC		40.5422369663
378PhosphorylationRKDTSAGSNIFSTGQ
CCCCCCCCCCCCCCC		26.8622369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BBP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BBP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BBP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MPS2_YEASTMPS2physical
10654940
SPC29_YEASTSPC29physical
10654940
KAR1_YEASTKAR1physical
10654940
BBP1_YEASTBBP1physical
11967834
KAR1_YEASTKAR1genetic
10654940
MPS2_YEASTMPS2genetic
10654940
POM34_YEASTPOM34genetic
19571182
SMY2_YEASTSMY2genetic
19571182
EAP1_YEASTEAP1genetic
19571182
SC160_YEASTSCP160genetic
19571182
CDC5_YEASTCDC5physical
15509790
BBP1_YEASTBBP1physical
20139001
MPS2_YEASTMPS2physical
20139001
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BBP1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-73, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory