KAR1_YEAST - dbPTM
KAR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KAR1_YEAST
UniProt AC P11927
Protein Name Cell division control protein KAR1
Gene Name KAR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 433
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein Description KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector..
Protein Sequence MNVTSPKDGNHSFSKKNRFNTNKPRFHKLNEQAQSINLPEDRDSIVSSNTTSIMTDDAFDYNEGIASRTKNINSDSDRSNDTIKQNNYNKRETGYNPFYNGSGINQRYTQFRKREFEPTLAENKAEEYISDEDNVKIDEDNIENELQFTPKIKEASILRSSLLGQRNVLNTRNPKSKESHIKVKPIINNKSSSQRKSSAALRKQLGKPLPLPYLNSPNSDSTPTLQRKEEVFTDEVLQKKRELIESKWHRLLFHDKKMVEKKLESLREYERKRMPPRGTDVSSSEQDNSFKISTPTKSYVSLEQKPLPNLSAMNNFNDVTDNKEKEETNNNILKFQAQRDPLQILQSEIEMHTKKLDTIIELLKDDTDSKEKRKVVTNDNAAPEQMVNKGWRKNVMMIYKKSGNIMKKYREYFLWTICILILLYCNIYVYYRF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MNVTSPKDGNH
----CCCCCCCCCCC		34.0229734811
5Phosphorylation---MNVTSPKDGNHS
---CCCCCCCCCCCC		26.1827717283
12PhosphorylationSPKDGNHSFSKKNRF
CCCCCCCCCCCCCCC		34.9021551504
14PhosphorylationKDGNHSFSKKNRFNT
CCCCCCCCCCCCCCC		45.8127717283
74PhosphorylationSRTKNINSDSDRSND
HCCCCCCCCCCCCCC		34.3923749301
76PhosphorylationTKNINSDSDRSNDTI
CCCCCCCCCCCCCCH		34.4427717283
79PhosphorylationINSDSDRSNDTIKQN
CCCCCCCCCCCHHHC		44.0127717283
82PhosphorylationDSDRSNDTIKQNNYN
CCCCCCCCHHHCCCC		34.0321551504
119PhosphorylationRKREFEPTLAENKAE
HHHCCCCHHHCCCHH		31.2521700874
128PhosphorylationAENKAEEYISDEDNV
HCCCHHHHCCCCCCC		9.3821700874
130PhosphorylationNKAEEYISDEDNVKI
CCHHHHCCCCCCCCC		33.7625521595
149PhosphorylationIENELQFTPKIKEAS
CCHHCCCCCHHHHHH		15.6528889911
156PhosphorylationTPKIKEASILRSSLL
CCHHHHHHHHHHHHH		24.2119779198
179PhosphorylationRNPKSKESHIKVKPI
CCCCCCCCCCEEEEC		33.9621700874
198PhosphorylationSSSQRKSSAALRKQL
CCHHHHCHHHHHHHH		22.1621700874
213PhosphorylationGKPLPLPYLNSPNSD
CCCCCCCCCCCCCCC		26.6321440633
216PhosphorylationLPLPYLNSPNSDSTP
CCCCCCCCCCCCCCC		23.9021700874
219PhosphorylationPYLNSPNSDSTPTLQ
CCCCCCCCCCCCCHH		36.0021700874
221PhosphorylationLNSPNSDSTPTLQRK
CCCCCCCCCCCHHHH		35.7921700874
222PhosphorylationNSPNSDSTPTLQRKE
CCCCCCCCCCHHHHH		25.8621440633
224PhosphorylationPNSDSTPTLQRKEEV
CCCCCCCCHHHHHHH		35.2921700874
233PhosphorylationQRKEEVFTDEVLQKK
HHHHHHCCHHHHHHH		36.1028889911
282PhosphorylationPPRGTDVSSSEQDNS
CCCCCCCCCCCCCCC		30.8430377154
283PhosphorylationPRGTDVSSSEQDNSF
CCCCCCCCCCCCCCC		37.4330377154
284PhosphorylationRGTDVSSSEQDNSFK
CCCCCCCCCCCCCCE		31.6019779198
289PhosphorylationSSSEQDNSFKISTPT
CCCCCCCCCEECCCC		35.8923749301
293PhosphorylationQDNSFKISTPTKSYV
CCCCCEECCCCCCEE		28.9923749301
294PhosphorylationDNSFKISTPTKSYVS
CCCCEECCCCCCEEC		38.1523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KAR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KAR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KAR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPC72_YEASTSPC72physical
10428957
SPC97_YEASTSPC97physical
10428957
SPC98_YEASTSPC98physical
10428957
TBG_YEASTTUB4physical
10428957
CDC31_YEASTCDC31physical
8188750
CDC31_YEASTCDC31genetic
8910460
SLT2_YEASTSLT2genetic
10924456
KPC1_YEASTPKC1genetic
10924456
SLG1_YEASTSLG1genetic
10924456
SWI4_YEASTSWI4genetic
10924456
CDC31_YEASTCDC31genetic
11156974
CDC31_YEASTCDC31genetic
8070654
DSK2_YEASTDSK2genetic
8070654
CNM67_YEASTCNM67genetic
10428957
XRN1_YEASTXRN1genetic
2076815
BCK1_YEASTBCK1genetic
10924456
CDC31_YEASTCDC31genetic
10924456
DSK2_YEASTDSK2genetic
10924456
SFI1_YEASTSFI1physical
26076691
CDC31_YEASTCDC31physical
26076691
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KAR1_YEAST

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Related Literatures of Post-Translational Modification

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