DSK2_YEAST - dbPTM
DSK2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DSK2_YEAST
UniProt AC P48510
Protein Name Ubiquitin domain-containing protein DSK2
Gene Name DSK2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 373
Subcellular Localization Nucleus .
Protein Description Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway..
Protein Sequence MSLNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRLIYSGKILKDDQTVESYHIQDGHSVHLVKSQPKPQTASAAGANNATATGAAAGTGATPNMSSGQSAGFNPLADLTSARYAGYLNMPSADMFGPDGGALNNDSNNQDELLRMMENPIFQSQMNEMLSNPQMLDFMIQSNPQLQAMGPQARQMLQSPMFRQMLTNPDMIRQSMQFARMMDPNAGMGSAGGAASAFPAPGGDAPEEGSNTNTTSSSNTGNNAGTNAGTNAGANTAANPFASLLNPALNPFANAGNAASTGMPAFDPALLASMFQPPVQASQAEDTRPPEERYEHQLRQLNDMGFFDFDRNVAALRRSGGSVQGALDSLLNGDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8UbiquitinationMSLNIHIKSGQDKWE
CCEEEEEECCCCCEE		34.0822817900
13AcetylationHIKSGQDKWEVNVAP
EEECCCCCEEEEECC		37.0524489116
13UbiquitinationHIKSGQDKWEVNVAP
EEECCCCCEEEEECC		37.0523749301
28UbiquitinationESTVLQFKEAINKAN
CHHHHHHHHHHHHHC		33.0222817900
33UbiquitinationQFKEAINKANGIPVA
HHHHHHHHHCCCEEC		36.8023749301
49UbiquitinationQRLIYSGKILKDDQT
CEEEEECEECCCCCE		38.6423749301
49AcetylationQRLIYSGKILKDDQT
CEEEEECEECCCCCE		38.6424489116
52AcetylationIYSGKILKDDQTVES
EEECEECCCCCEEEE		63.8324489116
52UbiquitinationIYSGKILKDDQTVES
EEECEECCCCCEEEE		63.8323749301
72UbiquitinationGHSVHLVKSQPKPQT
CCEEEEEECCCCCCC		50.1317644757
76UbiquitinationHLVKSQPKPQTASAA
EEEECCCCCCCCCCC		41.9623749301
97PhosphorylationATGAAAGTGATPNMS
CCCCCCCCCCCCCCC		20.9328889911
100PhosphorylationAAAGTGATPNMSSGQ
CCCCCCCCCCCCCCC		19.2828889911
104PhosphorylationTGATPNMSSGQSAGF
CCCCCCCCCCCCCCC		37.6521440633
105PhosphorylationGATPNMSSGQSAGFN
CCCCCCCCCCCCCCC		30.0428889911
145PhosphorylationGGALNNDSNNQDELL
CCCCCCCCCCHHHHH		39.5430377154
197PhosphorylationQARQMLQSPMFRQML
HHHHHHHCHHHHHHH		17.8625752575
205PhosphorylationPMFRQMLTNPDMIRQ
HHHHHHHHCHHHHHH		39.0922369663
357PhosphorylationNVAALRRSGGSVQGA
CHHHHHHCCCCHHHH		40.8628889911
360PhosphorylationALRRSGGSVQGALDS
HHHHCCCCHHHHHHH		18.1321440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DSK2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DSK2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DSK2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPN9_YEASTRPN9physical
12200120
PRS6A_YEASTRPT5physical
12200120
UBI4P_YEASTUBI4physical
15837191
PRS7_YEASTRPT1physical
11805328
UFD2_YEASTUFD2physical
15652483
RPN10_YEASTRPN10genetic
12051757
RAD23_YEASTRAD23genetic
8682868
PSB5_YEASTPRE2genetic
11805328
RPN1_YEASTRPN1genetic
11805328
SEM1_YEASTSEM1genetic
15572408
PSA3_YEASTPRE9genetic
15572408
YEC5_YEASTYEL025Cphysical
16554755
LYP1_YEASTLYP1physical
16554755
CUE5_YEASTCUE5physical
16554755
PRPD_YEASTPDH1physical
16554755
PTH2_YEASTPTH2physical
17082762
RPN10_YEASTRPN10physical
17082762
DSK2_YEASTDSK2physical
16140271
UBX1_YEASTSHP1genetic
17314980
EAF1_YEASTEAF1genetic
17314980
YPT6_YEASTYPT6genetic
17314980
RIC1_YEASTRIC1genetic
19061648
YPT6_YEASTYPT6genetic
19061648
ERF3_YEASTSUP35genetic
19061648
ARC1_YEASTARC1genetic
19061648
PRP11_YEASTPRP11genetic
19061648
EFTU_YEASTTUF1genetic
19061648
APQ12_YEASTAPQ12genetic
19061648
RNA14_YEASTRNA14genetic
19061648
WWM1_YEASTWWM1physical
18719252
RPN10_YEASTRPN10physical
18995839
RPN10_YEASTRPN10genetic
18995839
UBI4P_YEASTUBI4genetic
18995839
RPN11_YEASTRPN11genetic
18995839
PRS10_YEASTRPT4genetic
19446322
UFD2_YEASTUFD2physical
16338354
PRS7_YEASTRPT1physical
20061387
RPN11_YEASTRPN11physical
20061387
RPN12_YEASTRPN12physical
20061387
AAD10_YEASTAAD10genetic
19909498
PP2A4_YEASTPPG1genetic
19909498
GBB_YEASTSTE4genetic
19909498
DTR1_YEASTDTR1genetic
19909498
MSS11_YEASTMSS11genetic
19909498
CSC1_YEASTCSC1genetic
19909498
RFX1_YEASTRFX1genetic
19909498
VPH1_YEASTVPH1genetic
19909498
SPC98_YEASTSPC98genetic
19909498
RPB1_YEASTRPO21physical
21211725
RPN1_YEASTRPN1genetic
21763274
PSB5_YEASTPRE2genetic
21763274
UBI4P_YEASTUBI4physical
19620964
GTR4_HUMANSLC2A4physical
20854370
B2L11_RATBcl2l11physical
21378313
MK03_HUMANMAPK3physical
21378313
RPN10_YEASTRPN10physical
20059542
RPN13_YEASTRPN13physical
20059542
PSMD4_ARATHRPN10physical
20059542
PSMD4_HUMANPSMD4physical
20059542
RPN13_ARATHRPN13physical
20059542
ADRM1_HUMANADRM1physical
20059542
RPB1_YEASTRPO21physical
23056298
MPS1_YEASTMPS1genetic
22045814
ELOA1_YEASTELA1physical
23993092
ELOC_YEASTELC1physical
23993092
UBI4P_YEASTUBI4physical
11805328
IRC22_YEASTIRC22physical
24709957
UBI4P_YEASTUBI4physical
24709957
UBI4P_YEASTUBI4physical
12051757
UBI4P_YEASTUBI4physical
16140271
UBI4P_YEASTUBI4physical
17082762
RAD23_YEASTRAD23genetic
17082762
PRS7_YEASTRPT1physical
17082762
PRS6B_YEASTRPT3physical
17082762
PRS6A_YEASTRPT5physical
21627799
UBI4P_YEASTUBI4physical
15242647
RPN9_YEASTRPN9physical
12051757
UBI4P_YEASTUBI4physical
17198374
GTR4_HUMANSLC2A4physical
23424197
UBC_HUMANUBCphysical
16799550
UBI4P_YEASTUBI4physical
23649778
RPN10_YEASTRPN10physical
26450923
RPN10_YEASTRPN10genetic
26450923
CND2_YEASTBRN1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
DED1_YEASTDED1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
RPN6_YEASTRPN6genetic
27708008
CDC48_YEASTCDC48genetic
27708008
DAD1_YEASTDAD1genetic
27708008
SC61G_YEASTSSS1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
ACT_YEASTACT1genetic
27708008
SPT16_YEASTSPT16genetic
27708008
COG2_YEASTCOG2genetic
27708008
CP51_YEASTERG11genetic
27708008
CDC12_YEASTCDC12genetic
27708008
CDC11_YEASTCDC11genetic
27708008
SEC13_YEASTSEC13genetic
27708008
SPC24_YEASTSPC24genetic
27708008
MED4_YEASTMED4genetic
27708008
PSA7_YEASTPRE10genetic
27708008
DIM1_YEASTDIM1genetic
27708008
URA7_YEASTURA7genetic
27708008
BRE1_YEASTBRE1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
RTF1_YEASTRTF1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
ALAM_YEASTALT1genetic
27708008
PEX13_YEASTPEX13genetic
27708008
PHO84_YEASTPHO84genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
RPN10_YEASTRPN10physical
27698474
CUE5_YEASTCUE5physical
27477278
DSK2_YEASTDSK2physical
27477278
DVL2_HUMANDVL2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DSK2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; THR-205 ANDSER-357, AND MASS SPECTROMETRY.

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