dbPTM

IRC22_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRC22_YEAST
UniProt AC	P40006
Protein Name	Increased recombination centers protein 22
Gene Name	IRC22
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	225
Subcellular Localization	Endoplasmic reticulum membrane Single-pass type I membrane protein .
Protein Description	Is probably involved in a pathway contributing to genomic integrity..
Protein Sequence	MRFSMLIGFNLLTALSSFCAAISANNSDNVEHEQEVAEAVAPPSINIEVKYDVVGKESENHDSFLEFYAEDTATLAYNVTNWEDTNITIFGVNGTIVTYPHGYPVADITGASIGPYEMEVNGTSKFGQDVTLNLPEGQYFLIPFLLASRFDEIVRIAAPPTLFEIVSPPISFFNPQFLSVQVIFLAIIGGVSYYYMKSKTNQRPSKKSATVKKVDESWLPETYKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	Phosphorylation	DESWLPETYKK---- CHHHCCHHHCC----	38.41	27017623
223	Phosphorylation	ESWLPETYKK----- HHHCCHHHCC-----	18.34	27017623
224	Acetylation	SWLPETYKK------ HHCCHHHCC------	60.47	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IRC22_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRC22_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRC22_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YG36_YEAST	YGR126W	physical	16554755
CORO_YEAST	CRN1	physical	16554755
TSC3_YEAST	TSC3	genetic	16269340
SSH1_YEAST	SSH1	genetic	16269340
GDA1_YEAST	GDA1	genetic	16269340
PMA1_YEAST	PMA1	genetic	16269340
GSF2_YEAST	GSF2	genetic	16269340
PMT7_YEAST	PMT7	genetic	16269340
RS17B_YEAST	RPS17B	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
G3P3_YEAST	TDH3	physical	22940862
HSP72_YEAST	SSA2	physical	22940862
HSP7F_YEAST	SSE1	physical	22940862
DED1_YEAST	DED1	physical	22940862
YHI0_YEAST	YHR020W	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
UBI4P_YEAST	UBI4	physical	24709957
DSK2_YEAST	DSK2	genetic	24709957
MRM2_YEAST	MRM2	genetic	27708008
RSSA2_YEAST	RPS0B	genetic	27708008
MGR1_YEAST	MGR1	genetic	27708008
RTG2_YEAST	RTG2	genetic	27708008
MED20_YEAST	SRB2	genetic	27708008
GSH1_YEAST	GSH1	genetic	27708008
PIR5_YEAST	YJL160C	genetic	27708008
RL22A_YEAST	RPL22A	genetic	27708008
SIC1_YEAST	SIC1	genetic	27708008
HOG1_YEAST	HOG1	genetic	27708008
SRN2_YEAST	SRN2	genetic	27708008
UPS1_YEAST	UPS1	genetic	27708008
VRP1_YEAST	VRP1	genetic	27708008
FKS1_YEAST	FKS1	genetic	27708008
SUB1_YEAST	SUB1	genetic	27708008
PKR1_YEAST	PKR1	genetic	27708008
EOS1_YEAST	EOS1	genetic	27708008
RTG1_YEAST	RTG1	genetic	27708008
VAM10_YEAST	VAM10	genetic	27708008
VPS17_YEAST	VPS17	genetic	27708008
PDE2_YEAST	PDE2	genetic	27708008
TBP6_YEAST	YTA6	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRC22_YEAST

Related Literatures of Post-Translational Modification