dbPTM

YG36_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YG36_YEAST
UniProt AC	P53274
Protein Name	Uncharacterized protein YGR126W
Gene Name	YGR126W
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	230
Subcellular Localization
Protein Description
Protein Sequence	MPVPSVTVTTDNEYEDISSFSSIDSYKPEPFTGFKDSEAPEQPLLKNDTIVGKGQLEDDSNVDDQHRHSDVHSHHSSSTLKRPTSNSIEKMVTHNALEGNSETVDSLKEDGLNLNKKALPDITAPVTNSAHDAAFPEEYRLETETGLVKLKTLESLKREDSRVSSTKKEHINDHTDMHSTRSKVTTNSQGSSLEPNKLNMAVEKNKKRIEKYQKHKSEKGIKGFFHRIFD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Ubiquitination	APEQPLLKNDTIVGK CCCCCCCCCCEEECC	61.53	23749301
49	Phosphorylation	QPLLKNDTIVGKGQL CCCCCCCEEECCCCC	27.27	28889911
60	Phosphorylation	KGQLEDDSNVDDQHR CCCCCCCCCCCCCCC	51.58	28889911
69	Phosphorylation	VDDQHRHSDVHSHHS CCCCCCCCCCCCCCC	41.08	24961812
73	Phosphorylation	HRHSDVHSHHSSSTL CCCCCCCCCCCCCCC	23.81	28889911
76	Phosphorylation	SDVHSHHSSSTLKRP CCCCCCCCCCCCCCC	22.14	24961812
77	Phosphorylation	DVHSHHSSSTLKRPT CCCCCCCCCCCCCCC	24.00	24961812
78	Phosphorylation	VHSHHSSSTLKRPTS CCCCCCCCCCCCCCC	40.55	24961812
79	Phosphorylation	HSHHSSSTLKRPTSN CCCCCCCCCCCCCCC	37.94	24961812
81	Acetylation	HHSSSTLKRPTSNSI CCCCCCCCCCCCCCH	57.32	25381059
84	Phosphorylation	SSTLKRPTSNSIEKM CCCCCCCCCCCHHHH	44.57	19823750
85	Phosphorylation	STLKRPTSNSIEKMV CCCCCCCCCCHHHHH	31.12	19823750
87	Phosphorylation	LKRPTSNSIEKMVTH CCCCCCCCHHHHHHH	31.71	21551504
90	Ubiquitination	PTSNSIEKMVTHNAL CCCCCHHHHHHHHHH	36.68	24961812
93	Phosphorylation	NSIEKMVTHNALEGN CCHHHHHHHHHHCCC	13.10	22369663
101	Phosphorylation	HNALEGNSETVDSLK HHHHCCCCHHHHHHH	45.56	22369663
103	Phosphorylation	ALEGNSETVDSLKED HHCCCCHHHHHHHHH	29.45	22369663
106	Phosphorylation	GNSETVDSLKEDGLN CCCHHHHHHHHHCCC	36.68	22369663
152	Phosphorylation	TGLVKLKTLESLKRE CCCEEHHHHHHHHHC	46.31	24930733
155	Phosphorylation	VKLKTLESLKREDSR EEHHHHHHHHHCCCC	42.16	25704821
157	Ubiquitination	LKTLESLKREDSRVS HHHHHHHHHCCCCCC	64.12	24961812
161	Phosphorylation	ESLKREDSRVSSTKK HHHHHCCCCCCCCCH	29.81	19823750
164	Phosphorylation	KREDSRVSSTKKEHI HHCCCCCCCCCHHHC	31.05	21440633
165	Phosphorylation	REDSRVSSTKKEHIN HCCCCCCCCCHHHCC	41.19	21440633
166	Phosphorylation	EDSRVSSTKKEHIND CCCCCCCCCHHHCCC	38.33	19823750
167	Ubiquitination	DSRVSSTKKEHINDH CCCCCCCCHHHCCCC	59.10	24961812
168	Ubiquitination	SRVSSTKKEHINDHT CCCCCCCHHHCCCCC	55.39	24961812
175	Phosphorylation	KEHINDHTDMHSTRS HHHCCCCCCCCCCCC	37.57	28132839
179	Phosphorylation	NDHTDMHSTRSKVTT CCCCCCCCCCCCEEC	20.91	28132839
180	Phosphorylation	DHTDMHSTRSKVTTN CCCCCCCCCCCEECC	25.04	28889911
182	Phosphorylation	TDMHSTRSKVTTNSQ CCCCCCCCCEECCCC	31.40	24961812
183	Ubiquitination	DMHSTRSKVTTNSQG CCCCCCCCEECCCCC	40.07	24961812
185	Phosphorylation	HSTRSKVTTNSQGSS CCCCCCEECCCCCCC	24.81	22369663
186	Phosphorylation	STRSKVTTNSQGSSL CCCCCEECCCCCCCC	35.54	22369663
188	Phosphorylation	RSKVTTNSQGSSLEP CCCEECCCCCCCCCC	33.55	22369663
191	Phosphorylation	VTTNSQGSSLEPNKL EECCCCCCCCCCCHH	24.90	22369663
192	Phosphorylation	TTNSQGSSLEPNKLN ECCCCCCCCCCCHHH	43.51	22369663
197	Ubiquitination	GSSLEPNKLNMAVEK CCCCCCCHHHHHHHH	52.53	24961812
211	Acetylation	KNKKRIEKYQKHKSE HHHHHHHHHHHHHHH	51.08	25381059
219	Acetylation	YQKHKSEKGIKGFFH HHHHHHHHCCCHHHH	73.38	25381059
222	Acetylation	HKSEKGIKGFFHRIF HHHHHCCCHHHHHHC	59.33	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YG36_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YG36_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YG36_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRP8_YEAST	RRP8	genetic	19061648
NGR1_YEAST	NGR1	genetic	19061648
LTV1_YEAST	LTV1	genetic	19061648

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YG36_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85 AND SER-87, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85 AND SER-87, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.	17330950 [Abstract]