| UniProt ID | PMA1_YEAST | |
|---|---|---|
| UniProt AC | P05030 | |
| Protein Name | Plasma membrane ATPase 1 | |
| Gene Name | PMA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 918 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.. | |
| Protein Sequence | MTDTSSSSSSSSASSVSAHQPTQEKPAKTYDDAASESSDDDDIDALIEELQSNHGVDDEDSDNDGPVAAGEARPVPEEYLQTDPSYGLTSDEVLKRRKKYGLNQMADEKESLVVKFVMFFVGPIQFVMEAAAILAAGLSDWVDFGVICGLLMLNAGVGFVQEFQAGSIVDELKKTLANTAVVIRDGQLVEIPANEVVPGDILQLEDGTVIPTDGRIVTEDCFLQIDQSAITGESLAVDKHYGDQTFSSSTVKRGEGFMVVTATGDNTFVGRAAALVNKAAGGQGHFTEVLNGIGIILLVLVIATLLLVWTACFYRTNGIVRILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLKQYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESPEGERIVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEILGVMPCMDPPRDDTAQTVSEARHLGLRVKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIAILDNSLDIDLIVFIAIFADVATLAIAYDNAPYSPKPVKWNLPRLWGMSIILGIVLAIGSWITLTTMFLPKGGIIQNFGAMNGIMFLQISLTENWLIFITRAAGPFWSSIPSWQLAGAVFAVDIIATMFTLFGWWSENWTDIVTVVRVWIWSIGIFCVLGGFYYEMSTSEAFDRLMNGKPMKEKKSTRSVEDFMAAMQRVSTQHEKET | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTDTSSSSS ------CCCCCCCCC | 48.24 | 22369663 | |
| 4 | Phosphorylation | ----MTDTSSSSSSS ----CCCCCCCCCCC | 22.72 | 22369663 | |
| 5 | Phosphorylation | ---MTDTSSSSSSSS ---CCCCCCCCCCCC | 30.91 | 22369663 | |
| 6 | Phosphorylation | --MTDTSSSSSSSSA --CCCCCCCCCCCCC | 36.01 | 22369663 | |
| 7 | Phosphorylation | -MTDTSSSSSSSSAS -CCCCCCCCCCCCCC | 33.72 | 22369663 | |
| 8 | Phosphorylation | MTDTSSSSSSSSASS CCCCCCCCCCCCCCC | 35.87 | 22369663 | |
| 9 | Phosphorylation | TDTSSSSSSSSASSV CCCCCCCCCCCCCCC | 35.87 | 22369663 | |
| 10 | Phosphorylation | DTSSSSSSSSASSVS CCCCCCCCCCCCCCC | 30.20 | 22369663 | |
| 11 | Phosphorylation | TSSSSSSSSASSVSA CCCCCCCCCCCCCCC | 31.69 | 22369663 | |
| 12 | Phosphorylation | SSSSSSSSASSVSAH CCCCCCCCCCCCCCC | 33.83 | 22369663 | |
| 14 | Phosphorylation | SSSSSSASSVSAHQP CCCCCCCCCCCCCCC | 32.97 | 22369663 | |
| 15 | Phosphorylation | SSSSSASSVSAHQPT CCCCCCCCCCCCCCC | 21.58 | 22369663 | |
| 17 | Phosphorylation | SSSASSVSAHQPTQE CCCCCCCCCCCCCCC | 23.21 | 22369663 | |
| 22 | Phosphorylation | SVSAHQPTQEKPAKT CCCCCCCCCCCCCCC | 42.67 | 22369663 | |
| 25 | Ubiquitination | AHQPTQEKPAKTYDD CCCCCCCCCCCCHHH | 40.22 | 23749301 | |
| 28 | Ubiquitination | PTQEKPAKTYDDAAS CCCCCCCCCHHHHHH | 57.03 | 17644757 | |
| 52 | Phosphorylation | ALIEELQSNHGVDDE HHHHHHHHCCCCCCC | 43.34 | 27214570 | |
| 61 | Phosphorylation | HGVDDEDSDNDGPVA CCCCCCCCCCCCCCC | 35.94 | 27214570 | |
| 95 | Acetylation | LTSDEVLKRRKKYGL CCHHHHHHHHHHHCC | 56.16 | 24489116 | |
| 95 | Ubiquitination | LTSDEVLKRRKKYGL CCHHHHHHHHHHHCC | 56.16 | 24961812 | |
| 99 | Acetylation | EVLKRRKKYGLNQMA HHHHHHHHHCCHHHC | 42.62 | 22865919 | |
| 109 | Acetylation | LNQMADEKESLVVKF CHHHCCHHHHHHHHH | 53.82 | 24489116 | |
| 109 | Ubiquitination | LNQMADEKESLVVKF CHHHCCHHHHHHHHH | 53.82 | 23749301 | |
| 173 | Ubiquitination | GSIVDELKKTLANTA CCHHHHHHHHHCCEE | 41.48 | 17644757 | |
| 174 | Ubiquitination | SIVDELKKTLANTAV CHHHHHHHHHCCEEE | 62.49 | 17644757 | |
| 175 | Phosphorylation | IVDELKKTLANTAVV HHHHHHHHHCCEEEE | 29.52 | 28889911 | |
| 239 | Ubiquitination | GESLAVDKHYGDQTF CCCEEEEECCCCCEE | 31.93 | 23749301 | |
| 241 | Phosphorylation | SLAVDKHYGDQTFSS CEEEEECCCCCEECC | 28.30 | 21440633 | |
| 245 | Phosphorylation | DKHYGDQTFSSSTVK EECCCCCEECCCEEE | 30.17 | 21440633 | |
| 247 | Phosphorylation | HYGDQTFSSSTVKRG CCCCCEECCCEEECC | 27.11 | 21440633 | |
| 248 | Phosphorylation | YGDQTFSSSTVKRGE CCCCEECCCEEECCC | 26.32 | 21440633 | |
| 249 | Phosphorylation | GDQTFSSSTVKRGEG CCCEECCCEEECCCC | 35.70 | 28889911 | |
| 250 | Phosphorylation | DQTFSSSTVKRGEGF CCEECCCEEECCCCE | 31.81 | 21440633 | |
| 252 | 2-Hydroxyisobutyrylation | TFSSSTVKRGEGFMV EECCCEEECCCCEEE | 55.57 | - | |
| 252 | Acetylation | TFSSSTVKRGEGFMV EECCCEEECCCCEEE | 55.57 | 24489116 | |
| 252 | Ubiquitination | TFSSSTVKRGEGFMV EECCCEEECCCCEEE | 55.57 | 22817900 | |
| 261 | Phosphorylation | GEGFMVVTATGDNTF CCCEEEEEEECCCCC | 13.69 | 17287358 | |
| 267 | Phosphorylation | VTATGDNTFVGRAAA EEEECCCCCHHHHHH | 25.16 | 17287358 | |
| 356 | 2-Hydroxyisobutyrylation | GAAYLAKKQAIVQKL HHHHHHHHHHHHHHH | 39.08 | - | |
| 362 | Ubiquitination | KKQAIVQKLSAIESL HHHHHHHHHHHHHHH | 33.25 | 17644757 | |
| 379 | Acetylation | VEILCSDKTGTLTKN CEEEECCCCCCCCCC | 32.34 | 24489116 | |
| 379 | Ubiquitination | VEILCSDKTGTLTKN CEEEECCCCCCCCCC | 32.34 | 17644757 | |
| 380 | Phosphorylation | EILCSDKTGTLTKNK EEEECCCCCCCCCCC | 40.15 | 19823750 | |
| 382 | Phosphorylation | LCSDKTGTLTKNKLS EECCCCCCCCCCCEE | 36.16 | 19823750 | |
| 384 | Phosphorylation | SDKTGTLTKNKLSLH CCCCCCCCCCCEECC | 32.20 | 19795423 | |
| 385 | Acetylation | DKTGTLTKNKLSLHE CCCCCCCCCCEECCC | 56.02 | 24489116 | |
| 385 | Ubiquitination | DKTGTLTKNKLSLHE CCCCCCCCCCEECCC | 56.02 | 17644757 | |
| 387 | Acetylation | TGTLTKNKLSLHEPY CCCCCCCCEECCCCC | 40.80 | 24489116 | |
| 387 | Ubiquitination | TGTLTKNKLSLHEPY CCCCCCCCEECCCCC | 40.80 | 17644757 | |
| 389 | Phosphorylation | TLTKNKLSLHEPYTV CCCCCCEECCCCCEE | 29.32 | 21440633 | |
| 400 | Phosphorylation | PYTVEGVSPDDLMLT CCEECCCCHHHHHHH | 33.21 | 21440633 | |
| 415 | Ubiquitination | ACLAASRKKKGLDAI HHHHHHHHHCCHHHH | 57.23 | 22817900 | |
| 416 | Ubiquitination | CLAASRKKKGLDAID HHHHHHHHCCHHHHH | 51.46 | 22817900 | |
| 417 | Ubiquitination | LAASRKKKGLDAIDK HHHHHHHCCHHHHHH | 68.68 | 23749301 | |
| 424 | 2-Hydroxyisobutyrylation | KGLDAIDKAFLKSLK CCHHHHHHHHHHHHH | 34.62 | - | |
| 424 | Acetylation | KGLDAIDKAFLKSLK CCHHHHHHHHHHHHH | 34.62 | 24489116 | |
| 424 | Ubiquitination | KGLDAIDKAFLKSLK CCHHHHHHHHHHHHH | 34.62 | 23749301 | |
| 428 | Acetylation | AIDKAFLKSLKQYPK HHHHHHHHHHHHCCH | 47.49 | 24489116 | |
| 428 | Ubiquitination | AIDKAFLKSLKQYPK HHHHHHHHHHHHCCH | 47.49 | 23749301 | |
| 431 | Succinylation | KAFLKSLKQYPKAKD HHHHHHHHHCCHHHH | 55.68 | 23954790 | |
| 431 | Ubiquitination | KAFLKSLKQYPKAKD HHHHHHHHHCCHHHH | 55.68 | 23749301 | |
| 435 | Ubiquitination | KSLKQYPKAKDALTK HHHHHCCHHHHHHHH | 64.23 | 22817900 | |
| 437 | 2-Hydroxyisobutyrylation | LKQYPKAKDALTKYK HHHCCHHHHHHHHCC | 50.05 | - | |
| 437 | Acetylation | LKQYPKAKDALTKYK HHHCCHHHHHHHHCC | 50.05 | 24489116 | |
| 437 | Ubiquitination | LKQYPKAKDALTKYK HHHCCHHHHHHHHCC | 50.05 | 22817900 | |
| 442 | Acetylation | KAKDALTKYKVLEFH HHHHHHHHCCEEEEC | 43.88 | 24489116 | |
| 442 | Ubiquitination | KAKDALTKYKVLEFH HHHHHHHHCCEEEEC | 43.88 | 23749301 | |
| 444 | 2-Hydroxyisobutyrylation | KDALTKYKVLEFHPF HHHHHHCCEEEECCC | 41.73 | - | |
| 444 | Acetylation | KDALTKYKVLEFHPF HHHHHHCCEEEECCC | 41.73 | 24489116 | |
| 444 | Ubiquitination | KDALTKYKVLEFHPF HHHHHHCCEEEECCC | 41.73 | 23749301 | |
| 455 | Phosphorylation | FHPFDPVSKKVTAVV ECCCCCCCCCEEEEE | 31.95 | 21440633 | |
| 456 | 2-Hydroxyisobutyrylation | HPFDPVSKKVTAVVE CCCCCCCCCEEEEEE | 52.04 | - | |
| 456 | Acetylation | HPFDPVSKKVTAVVE CCCCCCCCCEEEEEE | 52.04 | 24489116 | |
| 456 | Succinylation | HPFDPVSKKVTAVVE CCCCCCCCCEEEEEE | 52.04 | 23954790 | |
| 456 | Ubiquitination | HPFDPVSKKVTAVVE CCCCCCCCCEEEEEE | 52.04 | 23749301 | |
| 457 | 2-Hydroxyisobutyrylation | PFDPVSKKVTAVVES CCCCCCCCEEEEEEC | 36.99 | - | |
| 457 | Ubiquitination | PFDPVSKKVTAVVES CCCCCCCCEEEEEEC | 36.99 | 23749301 | |
| 459 | Phosphorylation | DPVSKKVTAVVESPE CCCCCCEEEEEECCC | 23.71 | 20377248 | |
| 464 | Phosphorylation | KVTAVVESPEGERIV CEEEEEECCCCCEEE | 19.35 | 23749301 | |
| 474 | Acetylation | GERIVCVKGAPLFVL CCEEEEECCCEEEEE | 44.20 | 24489116 | |
| 474 | Ubiquitination | GERIVCVKGAPLFVL CCEEEEECCCEEEEE | 44.20 | 23749301 | |
| 482 | Acetylation | GAPLFVLKTVEEDHP CCEEEEEEECCCCCC | 45.26 | 24489116 | |
| 482 | Ubiquitination | GAPLFVLKTVEEDHP CCEEEEEEECCCCCC | 45.26 | 24961812 | |
| 501 | 2-Hydroxyisobutyrylation | VHENYENKVAELASR HHHHHHHHHHHHHHH | 30.77 | - | |
| 501 | Acetylation | VHENYENKVAELASR HHHHHHHHHHHHHHH | 30.77 | 24489116 | |
| 501 | Succinylation | VHENYENKVAELASR HHHHHHHHHHHHHHH | 30.77 | 23954790 | |
| 501 | Ubiquitination | VHENYENKVAELASR HHHHHHHHHHHHHHH | 30.77 | 23749301 | |
| 507 | Phosphorylation | NKVAELASRGFRALG HHHHHHHHHHHHHHH | 45.63 | 8943257 | |
| 518 | Ubiquitination | RALGVARKRGEGHWE HHHHCEEECCCCCEE | 55.83 | 17644757 | |
| 555 | 2-Hydroxyisobutyrylation | RHLGLRVKMLTGDAV HHHCCEEEEHHCCHH | 23.04 | - | |
| 555 | Ubiquitination | RHLGLRVKMLTGDAV HHHCCEEEEHHCCHH | 23.04 | 23749301 | |
| 558 | Phosphorylation | GLRVKMLTGDAVGIA CCEEEEHHCCHHHHH | 29.53 | 28889911 | |
| 566 | Acetylation | GDAVGIAKETCRQLG CCHHHHHHHHHHHCC | 52.19 | 24489116 | |
| 566 | Ubiquitination | GDAVGIAKETCRQLG CCHHHHHHHHHHHCC | 52.19 | 23749301 | |
| 576 | Phosphorylation | CRQLGLGTNIYNAER HHHCCCCCCCCCHHH | 24.40 | 24909858 | |
| 615 | Acetylation | AEVFPQHKYRVVEIL HHHCHHHCEEEEHHH | 29.51 | 25381059 | |
| 615 | Ubiquitination | AEVFPQHKYRVVEIL HHHCHHHCEEEEHHH | 29.51 | 23749301 | |
| 641 | Phosphorylation | DGVNDAPSLKKADTG CCCCCCCHHCCCCCC | 55.32 | 23749301 | |
| 643 | 2-Hydroxyisobutyrylation | VNDAPSLKKADTGIA CCCCCHHCCCCCCCC | 50.70 | - | |
| 643 | Acetylation | VNDAPSLKKADTGIA CCCCCHHCCCCCCCC | 50.70 | 24489116 | |
| 643 | Succinylation | VNDAPSLKKADTGIA CCCCCHHCCCCCCCC | 50.70 | 23954790 | |
| 643 | Ubiquitination | VNDAPSLKKADTGIA CCCCCHHCCCCCCCC | 50.70 | 22817900 | |
| 644 | 2-Hydroxyisobutyrylation | NDAPSLKKADTGIAV CCCCHHCCCCCCCCC | 57.71 | - | |
| 644 | Ubiquitination | NDAPSLKKADTGIAV CCCCHHCCCCCCCCC | 57.71 | 23749301 | |
| 647 | Phosphorylation | PSLKKADTGIAVEGA CHHCCCCCCCCCCCH | 35.03 | 25752575 | |
| 679 | Ubiquitination | SAIIDALKTSRQIFH HHHHHHHHHHHHHHH | 46.29 | 23749301 | |
| 873 | Phosphorylation | FCVLGGFYYEMSTSE HHHHHHHHHCCCHHH | 11.20 | 27214570 | |
| 874 | Phosphorylation | CVLGGFYYEMSTSEA HHHHHHHHCCCHHHH | 11.68 | 27214570 | |
| 896 | Phosphorylation | KPMKEKKSTRSVEDF CCCCCCCCCCCHHHH | 39.87 | 19823750 | |
| 897 | Phosphorylation | PMKEKKSTRSVEDFM CCCCCCCCCCHHHHH | 35.52 | 17287358 | |
| 899 | Phosphorylation | KEKKSTRSVEDFMAA CCCCCCCCHHHHHHH | 29.91 | 22369663 | |
| 911 | Phosphorylation | MAAMQRVSTQHEKET HHHHHHHHHHHHHCC | 25.25 | 22369663 | |
| 912 | Phosphorylation | AAMQRVSTQHEKET- HHHHHHHHHHHHCC- | 30.96 | 22369663 | |
| 916 | Acetylation | RVSTQHEKET----- HHHHHHHHCC----- | 65.61 | 24489116 | |
| 916 | Succinylation | RVSTQHEKET----- HHHHHHHHCC----- | 65.61 | 23954790 | |
| 916 | Ubiquitination | RVSTQHEKET----- HHHHHHHHCC----- | 65.61 | 23749301 | |
| 918 | Phosphorylation | STQHEKET------- HHHHHHCC------- | 55.78 | 22369663 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PMA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PMA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-61; SER-899;THR-912 AND THR-918, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-261; THR-267; SER-899;SER-911 AND THR-912, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899; SER-911; THR-912AND THR-918, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911 AND THR-912, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-912, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-912, AND MASSSPECTROMETRY. | |
| Ubiquitylation | |
| Reference | PubMed |
| "A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery."; Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.; Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-555; LYS-566 AND LYS-644,AND MASS SPECTROMETRY. | |
