LAG1_YEAST - dbPTM
LAG1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAG1_YEAST
UniProt AC P38703
Protein Name Sphingosine N-acyltransferase LAG1
Gene Name LAG1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 411
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein.
Protein Description Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span..
Protein Sequence MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MTSATDKSID
-----CCCCCHHCHH		28.0730377154
8PhosphorylationMTSATDKSIDRLVVN
CCCCCHHCHHHHHHC		32.3128889911
18PhosphorylationRLVVNAKTRRRNSSV
HHHHCCCCCCCCCCC		27.3124961812
23PhosphorylationAKTRRRNSSVGKIDL
CCCCCCCCCCCEECC		25.2922369663
24PhosphorylationKTRRRNSSVGKIDLG
CCCCCCCCCCEECCC		38.1422369663
33PhosphorylationGKIDLGDTVPGFAAM
CEECCCCCCCCCCCC		27.1422369663
43PhosphorylationGFAAMPESAASKNEA
CCCCCCHHHCCHHHH		24.2222369663
46PhosphorylationAMPESAASKNEAKKR
CCCHHHCCHHHHHHH		35.4122369663
103N-linked_GlycosylationSAYFLSGNRTESNPL
HHHHHCCCCCCCCCE		44.30-
389UbiquitinationLIWQGIQKDERSDSD
HHHHHHCCCCCCCCC		60.6824961812
395PhosphorylationQKDERSDSDSDESAE
CCCCCCCCCCCHHHH		40.0228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAG1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAG1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAG1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LAC1_YEASTLAC1genetic
10198056
LAC1_YEASTLAC1genetic
12869556
LAC1_YEASTLAC1genetic
11694577
YPC1_YEASTYPC1genetic
11694577
YDC1_YEASTYDC1genetic
11694577
LAC1_YEASTLAC1genetic
11387200
YPC1_YEASTYPC1genetic
15236759
YDC1_YEASTYDC1genetic
15236759
LAC1_YEASTLAC1physical
15692566
LIP1_YEASTLIP1physical
15692566
LAC1_YEASTLAC1genetic
16269340
PMA1_YEASTPMA1genetic
16269340
ROT1_YEASTROT1genetic
16269340
GAS1_YEASTGAS1genetic
16269340
GET1_YEASTGET1genetic
16269340
GUP1_YEASTGUP1genetic
16269340
ORM2_YEASTORM2genetic
16269340
COPE_YEASTSEC28genetic
16269340
SCS7_YEASTSCS7genetic
16269340
RGP1_YEASTRGP1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
LAC1_YEASTLAC1physical
11283351
LAC1_YEASTLAC1physical
18467557
SEC62_YEASTSEC62physical
18719252
LAC1_YEASTLAC1genetic
19210614
RIC1_YEASTRIC1genetic
20526336
SCS7_YEASTSCS7genetic
20526336
ELO3_YEASTELO3genetic
20526336
SEM1_YEASTSEM1genetic
20526336
LAC1_YEASTLAC1genetic
21173150
YPC1_YEASTYPC1genetic
21173150
YDC1_YEASTYDC1genetic
21173150
PLSC_YEASTSLC1genetic
21173150
LAC1_YEASTLAC1genetic
21623372
ELO3_YEASTELO3genetic
21623372
ERG2_YEASTERG2genetic
21623372
DS1P1_YEASTLCB3genetic
23891562
VBA1_YEASTVBA1genetic
23891562
UIP3_YEASTUIP3genetic
23891562
LAC1_YEASTLAC1genetic
23891562
GET2_YEASTGET2genetic
23891562
UBX1_YEASTSHP1genetic
23891562
ELO3_YEASTELO3genetic
23891562
SEC18_YEASTSEC18genetic
23891562
BEM2_YEASTBEM2genetic
23891562
KRR1_YEASTKRR1genetic
27708008
IPYR_YEASTIPP1genetic
27708008
CKS1_YEASTCKS1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
NSE4_YEASTNSE4genetic
27708008
BCP1_YEASTBCP1genetic
27708008
SMC1_YEASTSMC1genetic
27708008
MCE1_YEASTCEG1genetic
27708008
STS1_YEASTSTS1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRS7_YEASTRPT1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
MYO2_YEASTMYO2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
VPS10_YEASTPEP1genetic
27708008
RTG3_YEASTRTG3genetic
27708008
PEX19_YEASTPEX19genetic
27708008
MRK1_YEASTMRK1genetic
27708008
BEM2_YEASTBEM2genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
LAC1_YEASTLAC1genetic
27708008
GAL2_YEASTGAL2genetic
27708008
PEX13_YEASTPEX13genetic
27708008
HMX1_YEASTHMX1genetic
27708008
ELO3_YEASTELO3genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
MKT1_YEASTMKT1genetic
27708008
RCF2_YEASTRCF2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
YO159_YEASTYOL159Cgenetic
27708008
YVC1_YEASTYVC1genetic
27708008
PTP2_YEASTPTP2genetic
27708008
POC4_YEASTPOC4genetic
27708008
UBC9_HUMANUBE2Iphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAG1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND SER-24, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-24, AND MASSSPECTROMETRY.

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