| UniProt ID | CCW12_YEAST | |
|---|---|---|
| UniProt AC | Q12127 | |
| Protein Name | Covalently-linked cell wall protein 12 | |
| Gene Name | CCW12 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 133 | |
| Subcellular Localization |
Secreted, cell wall. Membrane Lipid-anchor, GPI-anchor. Covalently-linked GPI-modified cell wall protein (GPI-CWP). |
|
| Protein Description | Component of the cell wall. May play a role in the formation of a tightly packed outer mannan layer, which protects the inner glucan.. | |
| Protein Sequence | MQFSTVASIAAVAAVASAAANVTTATVSQESTTLVTITSCEDHVCSETVSPALVSTATVTVDDVITQYTTWCPLTTEAPKNGTSTAAPVTSTEAPKNTTSAAPTHSVTSYTGAAAKALPAAGALLAGAAALLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | O-linked_Glycosylation | ----MQFSTVASIAA ----CCHHHHHHHHH | 12.70 | 10322008 | |
| 21 | N-linked_Glycosylation | AVASAAANVTTATVS HHHHHHHCCCEEECC | 27.26 | 17315267 | |
| 23 | O-linked_Glycosylation | ASAAANVTTATVSQE HHHHHCCCEEECCCC | 15.55 | 15165243 | |
| 24 | O-linked_Glycosylation | SAAANVTTATVSQES HHHHCCCEEECCCCC | 18.95 | 15165243 | |
| 26 | O-linked_Glycosylation | AANVTTATVSQESTT HHCCCEEECCCCCEE | 20.71 | 15165243 | |
| 28 | O-linked_Glycosylation | NVTTATVSQESTTLV CCCEEECCCCCEEEE | 24.71 | 15165243 | |
| 31 | O-linked_Glycosylation | TATVSQESTTLVTIT EEECCCCCEEEEEEE | 21.03 | 15165243 | |
| 32 | O-linked_Glycosylation | ATVSQESTTLVTITS EECCCCCEEEEEEEE | 24.32 | 15165243 | |
| 33 | O-linked_Glycosylation | TVSQESTTLVTITSC ECCCCCEEEEEEEEC | 28.63 | 15165243 | |
| 36 | O-linked_Glycosylation | QESTTLVTITSCEDH CCCEEEEEEEECCCC | 22.96 | 15165243 | |
| 38 | O-linked_Glycosylation | STTLVTITSCEDHVC CEEEEEEEECCCCCC | 20.26 | 15165243 | |
| 39 | O-linked_Glycosylation | TTLVTITSCEDHVCS EEEEEEEECCCCCCC | 16.20 | 15165243 | |
| 46 | O-linked_Glycosylation | SCEDHVCSETVSPAL ECCCCCCCCCCCHHH | 34.90 | 15165243 | |
| 48 | O-linked_Glycosylation | EDHVCSETVSPALVS CCCCCCCCCCHHHCC | 15.25 | 15165243 | |
| 80 | Ubiquitination | PLTTEAPKNGTSTAA CCCCCCCCCCCCCCC | 75.06 | 22106047 | |
| 81 | N-linked_Glycosylation | LTTEAPKNGTSTAAP CCCCCCCCCCCCCCC | 58.89 | 17315267 | |
| 83 | Phosphorylation | TEAPKNGTSTAAPVT CCCCCCCCCCCCCCC | 32.09 | 27017623 | |
| 92 | Phosphorylation | TAAPVTSTEAPKNTT CCCCCCCCCCCCCCC | 27.14 | 27017623 | |
| 96 | Ubiquitination | VTSTEAPKNTTSAAP CCCCCCCCCCCCCCC | 74.17 | 17644757 | |
| 97 | N-linked_Glycosylation | TSTEAPKNTTSAAPT CCCCCCCCCCCCCCC | 47.75 | 17315267 | |
| 112 | GPI-anchor | HSVTSYTGAAAKALP CEECCCCCHHHHHHH | 12.65 | - | |
| 116 | Ubiquitination | SYTGAAAKALPAAGA CCCCHHHHHHHHHHH | 45.81 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCW12_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCW12_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCW12_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Characterization of Ccw12p, a major key player in cell wall stabilityof Saccharomyces cerevisiae."; Ragni E., Sipiczki M., Strahl S.; Yeast 24:309-319(2007). Cited for: FUNCTION, SUBCELLULAR LOCATION, AND GLYCOSYLATION AT ASN-21; ASN-81AND ASN-97. | |
