| UniProt ID | SKY1_YEAST | |
|---|---|---|
| UniProt AC | Q03656 | |
| Protein Name | Serine/threonine-protein kinase SKY1 | |
| Gene Name | SKY1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 742 | |
| Subcellular Localization | ||
| Protein Description | Constitutively active kinase, specifically and sequentially phosphorylates serine/arginine (SR)-type shuttling mRNA binding proteins in their RS dipeptide repeats.. | |
| Protein Sequence | MGSSINYPGFVTKSAHLADTSTDASISCEEATSSQEAKKNFFQRDYNMMKKAPAPTKSKLSLALQTSKSSSSANGTVQEDTSSKTEDFSTKSIKKKPDSGVESHVSIQSDSGPQSDSDLDSDSSISSCDERNEESLKDYRPGGYHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGDVEGIVQMVEALDKQKREAKRLQRHVSRSSDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSNNSFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEEVRDHKRH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSSINYPGF -----CCCCCCCCCC | 27.09 | 22369663 | |
| 4 | Phosphorylation | ----MGSSINYPGFV ----CCCCCCCCCCC | 14.77 | 22369663 | |
| 7 | Phosphorylation | -MGSSINYPGFVTKS -CCCCCCCCCCCCCC | 11.76 | 19823750 | |
| 14 | Phosphorylation | YPGFVTKSAHLADTS CCCCCCCCEEECCCC | 16.14 | 21440633 | |
| 20 | Phosphorylation | KSAHLADTSTDASIS CCEEECCCCCCCCCC | 28.11 | 21551504 | |
| 27 | Phosphorylation | TSTDASISCEEATSS CCCCCCCCCCCCCCC | 17.00 | 21551504 | |
| 33 | Phosphorylation | ISCEEATSSQEAKKN CCCCCCCCCHHHHHH | 36.75 | 20377248 | |
| 34 | Phosphorylation | SCEEATSSQEAKKNF CCCCCCCCHHHHHHH | 27.90 | 20377248 | |
| 56 | Phosphorylation | MKKAPAPTKSKLSLA HHCCCCCCCHHHHHH | 50.48 | 21440633 | |
| 58 | Phosphorylation | KAPAPTKSKLSLALQ CCCCCCCHHHHHHHH | 41.11 | 22369663 | |
| 61 | Phosphorylation | APTKSKLSLALQTSK CCCCHHHHHHHHCCC | 18.48 | 22369663 | |
| 66 | Phosphorylation | KLSLALQTSKSSSSA HHHHHHHCCCCCCCC | 38.68 | 19779198 | |
| 67 | Phosphorylation | LSLALQTSKSSSSAN HHHHHHCCCCCCCCC | 19.99 | 28152593 | |
| 69 | Phosphorylation | LALQTSKSSSSANGT HHHHCCCCCCCCCCC | 34.91 | 22369663 | |
| 70 | Phosphorylation | ALQTSKSSSSANGTV HHHCCCCCCCCCCCC | 31.86 | 22369663 | |
| 71 | Phosphorylation | LQTSKSSSSANGTVQ HHCCCCCCCCCCCCC | 40.33 | 22369663 | |
| 72 | Phosphorylation | QTSKSSSSANGTVQE HCCCCCCCCCCCCCC | 27.92 | 22369663 | |
| 76 | Phosphorylation | SSSSANGTVQEDTSS CCCCCCCCCCCCCCC | 20.87 | 22369663 | |
| 81 | Phosphorylation | NGTVQEDTSSKTEDF CCCCCCCCCCCCCCC | 33.86 | 22369663 | |
| 82 | Phosphorylation | GTVQEDTSSKTEDFS CCCCCCCCCCCCCCC | 42.00 | 22369663 | |
| 83 | Phosphorylation | TVQEDTSSKTEDFST CCCCCCCCCCCCCCC | 45.77 | 23749301 | |
| 84 | Ubiquitination | VQEDTSSKTEDFSTK CCCCCCCCCCCCCCC | 56.55 | 23749301 | |
| 85 | Phosphorylation | QEDTSSKTEDFSTKS CCCCCCCCCCCCCCC | 42.61 | 22369663 | |
| 89 | Phosphorylation | SSKTEDFSTKSIKKK CCCCCCCCCCCCCCC | 47.44 | 22369663 | |
| 90 | Phosphorylation | SKTEDFSTKSIKKKP CCCCCCCCCCCCCCC | 28.89 | 22369663 | |
| 91 | Acetylation | KTEDFSTKSIKKKPD CCCCCCCCCCCCCCC | 49.32 | 25381059 | |
| 193 | Ubiquitination | MKIVRGDKVYTEAAE EEEEECCCEEHHHHH | 39.71 | 23749301 | |
| 332 | Phosphorylation | KRLQRHVSRSSDITA HHHHHHHHHHCCCCC | 21.96 | 22369663 | |
| 334 | Phosphorylation | LQRHVSRSSDITAND HHHHHHHHCCCCCCC | 25.51 | 22890988 | |
| 335 | Phosphorylation | QRHVSRSSDITANDS HHHHHHHCCCCCCCC | 31.74 | 22369663 | |
| 338 | Phosphorylation | VSRSSDITANDSSDE HHHHCCCCCCCCCHH | 25.13 | 22369663 | |
| 342 | Phosphorylation | SDITANDSSDEKWAE CCCCCCCCCHHHHHH | 39.22 | 22890988 | |
| 343 | Phosphorylation | DITANDSSDEKWAEC CCCCCCCCHHHHHHC | 53.29 | 22890988 | |
| 358 | Phosphorylation | QTSMPCGSSSNSKSR CCCCCCCCCCCCCCC | 36.99 | 21440633 | |
| 359 | Phosphorylation | TSMPCGSSSNSKSRS CCCCCCCCCCCCCCC | 20.87 | 21440633 | |
| 360 | Phosphorylation | SMPCGSSSNSKSRSI CCCCCCCCCCCCCCH | 46.98 | 21440633 | |
| 362 | Phosphorylation | PCGSSSNSKSRSIEK CCCCCCCCCCCCHHH | 33.68 | 20377248 | |
| 366 | Phosphorylation | SSNSKSRSIEKDLSK CCCCCCCCHHHHHHH | 42.04 | 21440633 | |
| 369 | Acetylation | SKSRSIEKDLSKRCF CCCCCHHHHHHHHHH | 63.40 | 25381059 | |
| 383 | Phosphorylation | FRRPRRHTIITGSQP HCCCCCCEEEECCCC | 16.56 | 22369663 | |
| 386 | Phosphorylation | PRRHTIITGSQPLPS CCCCEEEECCCCCCC | 27.25 | 22369663 | |
| 388 | Phosphorylation | RHTIITGSQPLPSPI CCEEEECCCCCCCCC | 21.70 | 22369663 | |
| 393 | Phosphorylation | TGSQPLPSPISSSNF ECCCCCCCCCCCCCC | 42.42 | 22369663 | |
| 396 | Phosphorylation | QPLPSPISSSNFFEM CCCCCCCCCCCCEEE | 30.97 | 22369663 | |
| 397 | Phosphorylation | PLPSPISSSNFFEMR CCCCCCCCCCCEEEE | 29.98 | 22369663 | |
| 398 | Phosphorylation | LPSPISSSNFFEMRA CCCCCCCCCCEEEEE | 30.76 | 22369663 | |
| 410 | Phosphorylation | MRAHFCGSSHNSFSS EEEEECCCCCCCCCC | 29.61 | 19684113 | |
| 411 | Phosphorylation | RAHFCGSSHNSFSSV EEEECCCCCCCCCCC | 16.39 | 19684113 | |
| 414 | Phosphorylation | FCGSSHNSFSSVSGN ECCCCCCCCCCCCCC | 22.53 | 19684113 | |
| 416 | Phosphorylation | GSSHNSFSSVSGNRN CCCCCCCCCCCCCCC | 29.65 | 28889911 | |
| 417 | Phosphorylation | SSHNSFSSVSGNRNI CCCCCCCCCCCCCCC | 20.49 | 19779198 | |
| 419 | Phosphorylation | HNSFSSVSGNRNIPS CCCCCCCCCCCCCCC | 32.09 | 28889911 | |
| 426 | Phosphorylation | SGNRNIPSSINNNSI CCCCCCCCCCCCCCC | 39.80 | 24909858 | |
| 427 | Phosphorylation | GNRNIPSSINNNSIN CCCCCCCCCCCCCCC | 24.79 | 21082442 | |
| 432 | Phosphorylation | PSSINNNSINNGIGI CCCCCCCCCCCCCCE | 28.90 | 22369663 | |
| 442 | Phosphorylation | NGIGIKNSNNSFLNS CCCCEECCCCCHHHC | 32.17 | 22369663 | |
| 445 | Phosphorylation | GIKNSNNSFLNSVPH CEECCCCCHHHCCCC | 35.05 | 22369663 | |
| 449 | Phosphorylation | SNNSFLNSVPHSVTR CCCCHHHCCCCCCEE | 38.89 | 22369663 | |
| 453 | Phosphorylation | FLNSVPHSVTRMFIN HHHCCCCCCEEEECC | 21.08 | 22369663 | |
| 455 | Phosphorylation | NSVPHSVTRMFINED HCCCCCCEEEECCCC | 21.30 | 22369663 | |
| 463 | Phosphorylation | RMFINEDSNDNNNND EEECCCCCCCCCCCC | 39.65 | 28889911 | |
| 557 | Phosphorylation | DLGNACWYDEHYTNS CCCCCCCCCHHHCCC | 16.02 | 23749301 | |
| 642 | Phosphorylation | RNGKYTRTFFNSRGL HCCCCEEEEECCHHH | 25.44 | 28889911 | |
| 646 | Phosphorylation | YTRTFFNSRGLLRNI CEEEEECCHHHHHHH | 23.67 | 28889911 | |
| 657 | Acetylation | LRNISKLKFWPLEDV HHHHHHCCCCCHHHH | 49.47 | 24489116 | |
| 725 | Phosphorylation | PDRELYGSGSDIPGW CCHHHCCCCCCCCCH | 22.90 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SKY1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SKY1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SKY1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-388; SER-393;SER-396; SER-427; SER-432; SER-445; SER-449 AND SER-453, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-396 ANDSER-445, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-383; SER-393; SER-449AND SER-453, AND MASS SPECTROMETRY. | |
