UTP25_YEAST - dbPTM
UTP25_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UTP25_YEAST
UniProt AC P40498
Protein Name U3 small nucleolar RNA-associated protein 25
Gene Name UTP25
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 721
Subcellular Localization Nucleus, nucleolus .
Protein Description DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2..
Protein Sequence MSDSSVREKNDNFRGYRKRGRQELRKIKRSSARTEGGSTETLEDVAEDIDHRSDEDEVSDVDSGDDFDIEDEEGKKEKVYDALLTILKSEHPEPKRRRREADESNKAPAEVGEDEHENTEHGPVDDQLEIENGLLGNHEDDNDDDSSGDEKDIDSEDEQDPFESHFNQVPEKFVDKLSNAFKTKSVKYKSVKGSLSDSESYIYAKPVVIGEEALVESPYRSSSIYSYFLKQRLKVQNGLLDKKTDPLTALQKKLVDPMFQYKDILYEYDSYEKDEDEYRDLYALHVLNHIYKTRDRILKNNQRLQDNPDTEHLDQGFTRPKVLIVVPTREVAYRVVDKIISKSGIDQVDKKGKFYDQFRDDSLPPKSKPKSFQHIFRGNTNDFFVVGLKFTRKAIKLYSNFYQSDIIVCSPLGIQMILENTDKKKRQDDFLSSIELMVIDQLHSIEYQNISHIFTIFDHLNKIPDQQHEADFSRIRMWYINEQAKLFRQTMVFTKYISPAANSLINGRCRNMAGRWKNHKVIGSENSSIGQSGLKIRQIFQRFDIIGNSIIEEPDYRFKFFTSVIIPGIVKSTGYEDGILIYIPDYTDFIRIRNYMKEKTTILFGDINEYSSQRQLNANRSLFQQGRLKVMLYTERLHHYRRYEIKGVKSVVFYKPPNNPEFYNEVVRFIGKNAFLGNTDLNISTVRCIYSKLDGLSLERIVGTKRAAVLSHAQKEIYEFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDSSVREK
------CCCHHHHCC		46.3127717283
4Phosphorylation----MSDSSVREKND
----CCCHHHHCCCC		24.3527717283
5Phosphorylation---MSDSSVREKNDN
---CCCHHHHCCCCC		30.1327717283
38PhosphorylationSARTEGGSTETLEDV
CCCCCCCCCCCHHHH		33.6527214570
39PhosphorylationARTEGGSTETLEDVA
CCCCCCCCCCHHHHH		35.9430377154
53PhosphorylationAEDIDHRSDEDEVSD
HHHCCCCCCCCCCCC		41.7628889911
59PhosphorylationRSDEDEVSDVDSGDD
CCCCCCCCCCCCCCC		29.8419795423
63PhosphorylationDEVSDVDSGDDFDIE
CCCCCCCCCCCCCCC		43.9219795423
88AcetylationDALLTILKSEHPEPK
HHHHHHHHCCCCCCH		50.3624489116
146PhosphorylationEDDNDDDSSGDEKDI
CCCCCCCCCCCCCCC		43.1227738172
147PhosphorylationDDNDDDSSGDEKDID
CCCCCCCCCCCCCCC		58.2027738172
155PhosphorylationGDEKDIDSEDEQDPF
CCCCCCCCCCCCCHH		47.4822369663
164PhosphorylationDEQDPFESHFNQVPE
CCCCHHHHHHHHCCH		33.4822890988
176AcetylationVPEKFVDKLSNAFKT
CCHHHHHHHHHHHCC		48.8124489116
185PhosphorylationSNAFKTKSVKYKSVK
HHHHCCCCCEEEEEC		29.1319823750
188PhosphorylationFKTKSVKYKSVKGSL
HCCCCCEEEEECCCC		13.3119823750
190PhosphorylationTKSVKYKSVKGSLSD
CCCCEEEEECCCCCC		26.4319823750
194PhosphorylationKYKSVKGSLSDSESY
EEEEECCCCCCCCCE		20.9822369663
196PhosphorylationKSVKGSLSDSESYIY
EEECCCCCCCCCEEE		40.5622369663
198PhosphorylationVKGSLSDSESYIYAK
ECCCCCCCCCEEEEE		25.6822369663
200PhosphorylationGSLSDSESYIYAKPV
CCCCCCCCEEEEECE		22.3022369663
201PhosphorylationSLSDSESYIYAKPVV
CCCCCCCEEEEECEE		8.2322369663
203PhosphorylationSDSESYIYAKPVVIG
CCCCCEEEEECEEEC		10.5922369663
396UbiquitinationKFTRKAIKLYSNFYQ
HHHHHHHHHHHHHHC		46.3523749301
402PhosphorylationIKLYSNFYQSDIIVC
HHHHHHHHCCCEEEE		16.0323749301
404PhosphorylationLYSNFYQSDIIVCSP
HHHHHHCCCEEEEEH		21.2823749301
684PhosphorylationGNTDLNISTVRCIYS
CCCCCCHHHHHHHHH		21.5630377154
685PhosphorylationNTDLNISTVRCIYSK
CCCCCHHHHHHHHHC		14.2630377154
692UbiquitinationTVRCIYSKLDGLSLE
HHHHHHHCCCCCCHH		33.3623749301
692AcetylationTVRCIYSKLDGLSLE
HHHHHHHCCCCCCHH		33.3624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UTP25_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UTP25_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UTP25_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SAS10_YEASTSAS10physical
16554755
MPP10_YEASTMPP10physical
16554755
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
SAS10_YEASTSAS10physical
20528918
MPP10_YEASTMPP10physical
20528918
MPP10_YEASTMPP10physical
20884785
UTP8_YEASTUTP8physical
20884785
UTP18_YEASTUTP18physical
20884785
RRP9_YEASTRRP9physical
20884785
SAS10_YEASTSAS10physical
20884785
UTP21_YEASTUTP21physical
20884785
RS8A_YEASTRPS8Aphysical
23604635
RS8B_YEASTRPS8Aphysical
23604635
LDS2_YEASTLDS2genetic
27708008
MSH2_YEASTMSH2genetic
27708008
SCC1_YEASTMCD1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SNU56_YEASTSNU56genetic
27708008
CDC20_YEASTCDC20genetic
27708008
RRP3_YEASTRRP3genetic
27708008
ORC6_YEASTORC6genetic
27708008
NEP1_YEASTEMG1genetic
27708008
ERB1_YEASTERB1genetic
27708008
NAT10_YEASTKRE33genetic
27708008
APC5_YEASTAPC5genetic
27708008
DIB1_YEASTDIB1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
STU1_YEASTSTU1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
CALM_YEASTCMD1genetic
27708008
USO1_YEASTUSO1genetic
27708008
CDC48_YEASTCDC48genetic
27708008
TRS23_YEASTTRS23genetic
27708008
COG3_YEASTCOG3genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
UTP9_YEASTUTP9genetic
27708008
RRN7_YEASTRRN7genetic
27708008
YKT6_YEASTYKT6genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
ERG27_YEASTERG27genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
SPC24_YEASTSPC24genetic
27708008
VTI1_YEASTVTI1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ICS2_YEASTICS2genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RV167_YEASTRVS167genetic
27708008
APT2_YEASTAPT2genetic
27708008
SNX4_YEASTSNX4genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
UBL1_YEASTYUH1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
SAC1_YEASTSAC1genetic
27708008
YL346_YEASTYLR346Cgenetic
27708008
CSI1_YEASTCSI1genetic
27708008
CBPY_YEASTPRC1genetic
27708008
HDA1_YEASTHDA1genetic
27708008
PMS1_YEASTPMS1genetic
27708008
EDE1_YEASTEDE1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
SCS22_YEASTSCS22genetic
27708008
H3_YEASTHHT1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
HAL4_YEASTSAT4genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
RPN4_YEASTRPN4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
YD241_YEASTYDL241Wgenetic
27708008
PP4C_YEASTPPH3genetic
27708008
VPS41_YEASTVPS41genetic
27708008
INO2_YEASTINO2genetic
27708008
SWF1_YEASTSWF1genetic
27708008
NUM1_YEASTNUM1genetic
27708008
YAP6_YEASTYAP6genetic
27708008
ATO3_YEASTATO3genetic
27708008
COG7_YEASTCOG7genetic
27708008
CGR1_YEASTCGR1genetic
27708008
TFS2_YEASTDST1genetic
27708008
ERV14_YEASTERV14genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
VMA21_YEASTVMA21genetic
27708008
PSD2_YEASTPSD2genetic
27708008
TBP7_YEASTYTA7genetic
27708008
MAL12_YEASTMAL12genetic
27708008
INM1_YEASTINM1genetic
27708008
AIM18_YEASTAIM18genetic
27708008
MOG1_YEASTMOG1genetic
27708008
MPCP_YEASTMIR1genetic
27708008
DYHC_YEASTDYN1genetic
27708008
PAM17_YEASTPAM17genetic
27708008
SRL3_YEASTSRL3genetic
27708008
LDB18_YEASTLDB18genetic
27708008
RIC1_YEASTRIC1genetic
27708008
RS3A1_YEASTRPS1Agenetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
RAD14_YEASTRAD14genetic
27708008
JNM1_YEASTJNM1genetic
27708008
DYN3_YEASTDYN3genetic
27708008
PET8_YEASTPET8genetic
27708008
COG5_YEASTCOG5genetic
27708008
WHI5_YEASTWHI5genetic
27708008
RUD3_YEASTRUD3genetic
27708008
LIS1_YEASTPAC1genetic
27708008
HAP5_YEASTHAP5genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
KAR3_YEASTKAR3genetic
27708008
ADIP_HUMANSSX2IPphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UTP25_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND MASSSPECTROMETRY.

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