UTP18_YEAST - dbPTM
UTP18_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UTP18_YEAST
UniProt AC P40362
Protein Name U3 small nucleolar RNA-associated protein 18
Gene Name UTP18
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 594
Subcellular Localization Nucleus, nucleolus .
Protein Description Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly..
Protein Sequence MTMATTAMNVSVPPPDEEEQLLAKFVFGDTTDLQENLAKFNADFIFNEQEMDVEDQEDEGSESDNSEEDEAQNGELDHVNNDQLFFVDDGGNEDSQDKNEDTMDVDDEDDSSSDDYSEDSEEAAWIDSDDEKIKVPILVTNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSELDDEEDDEEEGSNNVINGDINALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTMATTAMN
------CCCCCCCCE
18.6030377154
6Phosphorylation--MTMATTAMNVSVP
--CCCCCCCCEECCC
17.8630377154
11PhosphorylationATTAMNVSVPPPDEE
CCCCCEECCCCCCHH
24.7330377154
31PhosphorylationKFVFGDTTDLQENLA
HHHHCCCCCHHHHHH
39.1821551504
134UbiquitinationDSDDEKIKVPILVTN
CCCCCEEEECEEEEC
53.6923749301
154AcetylationRTSYNESKINGVHYI
CCCCCHHHCCHHHHH
33.7324489116
170AcetylationRLRSQFEKIYPRPKW
HHHHHHHHHCCCCCC
49.1524489116
182PhosphorylationPKWVDDESDSELDDE
CCCCCCCCCCCCCCC
54.1320377248
184PhosphorylationWVDDESDSELDDEED
CCCCCCCCCCCCCCC
49.7120377248
213PhosphorylationNALTKILSTTYNYKD
HHHHHHHHCCCCCCC
23.3722369663
214PhosphorylationALTKILSTTYNYKDT
HHHHHHHCCCCCCCC
29.8322369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UTP18_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UTP18_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UTP18_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UTP21_YEASTUTP21physical
14759368
UTP12_YEASTDIP2physical
14759368
PWP2_YEASTPWP2physical
14759368
UTP13_YEASTUTP13physical
14759368
UTP6_YEASTUTP6physical
14759368
UTP18_YEASTUTP18physical
14759368
PWP2_YEASTPWP2physical
11805826
SYSM_YEASTDIA4physical
11805826
UTP12_YEASTDIP2physical
11805826
UTP4_YEASTUTP4physical
11805826
UTP6_YEASTUTP6physical
11805826
UTP22_YEASTUTP22physical
11805826
UTP10_YEASTUTP10physical
11805826
UTP13_YEASTUTP13physical
11805826
UTP21_YEASTUTP21physical
11805826
UTP15_YEASTUTP15physical
11805826
YO059_YEASTLPL1physical
11805826
RRP5_YEASTRRP5physical
11805837
UTP11_YEASTUTP11physical
11805837
FBRL_YEASTNOP1physical
11805837
PWP2_YEASTPWP2physical
11805837
NAT10_YEASTKRE33physical
11805837
CSK2C_YEASTCKB2physical
11805837
RL1D1_YEASTUTP30physical
11805837
UTP17_YEASTNAN1physical
11805837
PDP1_YEASTPTC5physical
11805837
UTP14_YEASTUTP14physical
11805837
NOP56_YEASTNOP56physical
11805837
UTP22_YEASTUTP22physical
11805837
PNO1_YEASTPNO1physical
11805837
CSK21_YEASTCKA1physical
11805837
CSK2B_YEASTCKB1physical
11805837
UTP21_YEASTUTP21physical
11805837
CSK22_YEASTCKA2physical
11805837
LCP5_YEASTLCP5physical
11805837
VATA_YEASTVMA1physical
11805837
UTP6_YEASTUTP6physical
11805837
PRP40_YEASTPRP40physical
11805837
ESL2_YEASTESL2physical
11805837
UTP12_YEASTDIP2physical
11805837
UTP13_YEASTUTP13physical
11805837
UTP10_YEASTUTP10physical
11805837
UTP12_YEASTDIP2physical
12150911
PWP2_YEASTPWP2physical
12150911
UTP4_YEASTUTP4physical
12150911
UTP6_YEASTUTP6physical
12150911
UTP22_YEASTUTP22physical
12150911
UTP18_YEASTUTP18physical
12150911
UTP10_YEASTUTP10physical
12150911
UTP13_YEASTUTP13physical
12150911
UTP21_YEASTUTP21physical
12150911
UTP15_YEASTUTP15physical
12150911
MPP10_YEASTMPP10physical
15590835
UTP12_YEASTDIP2physical
16554755
UTP13_YEASTUTP13physical
16554755
UTP21_YEASTUTP21physical
16554755
UTP12_YEASTDIP2physical
16429126
PWP2_YEASTPWP2physical
16429126
UTP10_YEASTUTP10physical
16429126
UTP13_YEASTUTP13physical
16429126
UTP21_YEASTUTP21physical
16429126
UTP6_YEASTUTP6physical
16429126
UTP22_YEASTUTP22physical
16429126
YO059_YEASTLPL1physical
16429126
UTP4_YEASTUTP4physical
16429126
UTP15_YEASTUTP15physical
16429126
UTP8_YEASTUTP8physical
17634288
EIF3G_YEASTTIF35genetic
19061648
BUD21_YEASTBUD21genetic
19061648
UBP6_YEASTUBP6genetic
19061648
PIH1_YEASTPIH1genetic
19061648
UTP21_YEASTUTP21physical
24466140
RS8A_YEASTRPS8Aphysical
23604635
RS8B_YEASTRPS8Aphysical
23604635
PXR1_YEASTPXR1physical
24823796
MCM1_YEASTMCM1genetic
27708008
ATG15_YEASTATG15genetic
27708008
TFS2_YEASTDST1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
MED20_YEASTSRB2genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
IES4_YEASTIES4genetic
27708008
RU2A_YEASTLEA1genetic
27708008
TDA1_YEASTTDA1genetic
27708008
STU1_YEASTSTU1genetic
27708008
ARPC1_YEASTARC40genetic
27708008
FAD1_YEASTFAD1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
CDC37_YEASTCDC37genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
UTP5_YEASTUTP5genetic
27708008
GNA1_YEASTGNA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RSC8_YEASTRSC8genetic
27708008
YHS2_YEASTCIA2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
UTP13_YEASTUTP13genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
SEN1_YEASTSEN1genetic
27708008
NAT10_YEASTKRE33genetic
27708008
APC5_YEASTAPC5genetic
27708008
RPN7_YEASTRPN7genetic
27708008
DPOD_YEASTPOL3genetic
27708008
GLE1_YEASTGLE1genetic
27708008
UTP6_YEASTUTP6genetic
27708008
USE1_YEASTUSE1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
SAM35_YEASTSAM35genetic
27708008
BIG1_YEASTBIG1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
NBP1_YEASTNBP1genetic
27708008
RPC6_YEASTRPC34genetic
27708008
IPL1_YEASTIPL1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
STE50_YEASTSTE50genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
VPS41_YEASTVPS41genetic
27708008
INO2_YEASTINO2genetic
27708008
XRS2_YEASTXRS2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
APT2_YEASTAPT2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
RAD54_YEASTRAD54genetic
27708008
RTF1_YEASTRTF1genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
GTR2_YEASTGTR2genetic
27708008
PHB2_YEASTPHB2genetic
27708008
MAL12_YEASTMAL12genetic
27708008
PUT2_YEASTPUT2genetic
27708008
ATG32_YEASTATG32genetic
27708008
SAC1_YEASTSAC1genetic
27708008
MLP1_YEASTMLP1genetic
27708008
STB4_YEASTSTB4genetic
27708008
MRE11_YEASTMRE11genetic
27708008
PET8_YEASTPET8genetic
27708008
SIN3_YEASTSIN3genetic
27708008
LDS2_YEASTLDS2genetic
27708008
WHI5_YEASTWHI5genetic
27708008
NPT1_YEASTNPT1genetic
27708008
HAT1_YEASTHAT1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
ISU1_YEASTISU1genetic
27708008
COX10_YEASTCOX10genetic
27708008
NEW1_YEASTNEW1genetic
27708008
NAA30_YEASTMAK3genetic
27708008
CTF4_YEASTCTF4genetic
27708008
NTH1_YEASTNTG1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
BAP3_YEASTBAP3genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
RAD4_YEASTRAD4genetic
27708008
TNA1_YEASTTNA1genetic
27708008
OPI1_YEASTOPI1genetic
27708008
HOS4_YEASTHOS4genetic
27708008
YJ9K_YEASTYJR146Wgenetic
27708008
CYT2_YEASTCYT2genetic
27708008
ELF1_YEASTELF1genetic
27708008
POM33_YEASTPOM33genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
HRB1_YEASTHRB1genetic
27708008
MKT1_YEASTMKT1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
NOP12_YEASTNOP12genetic
27708008
MSB4_YEASTMSB4genetic
27708008
CY1_YEASTCYT1genetic
27708008
CHL1_YEASTCHL1genetic
27708008

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UTP18_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND MASSSPECTROMETRY.

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