| UniProt ID | PNO1_YEAST | |
|---|---|---|
| UniProt AC | Q99216 | |
| Protein Name | Pre-rRNA-processing protein PNO1 | |
| Gene Name | PNO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 274 | |
| Subcellular Localization | Cytoplasm . Nucleus, nucleolus . | |
| Protein Description | Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species. Recruits DIM1 to nucleolar pre-RNAs. Indirectly required for cleavage at the A2 site of the 20S pre-rRNA, forming 18S rRNA, and at A1 and A2 sites of other pre-rRNAs.. | |
| Protein Sequence | MVAPTALKKATVTPVSGQDGGSSRIIGINNTESIDEDDDDDVLLDDSDNNTAKEEVEGEEGSRKTHESKTVVVDDQGKPRFTSASKTQGNKIKFESRKIMVPPHRMTPLRNSWTKIYPPLVEHLKLQVRMNLKTKSVELRTNPKFTTDPGALQKGADFIKAFTLGFDLDDSIALLRLDDLYIETFEVKDVKTLTGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMARESVVSLILGSPPGKVYGNLRTVASRLKERY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | PTALKKATVTPVSGQ CCCCCCCEEECCCCC | 33.52 | 23749301 | |
| 13 | Phosphorylation | ALKKATVTPVSGQDG CCCCCEEECCCCCCC | 17.39 | 23749301 | |
| 16 | Phosphorylation | KATVTPVSGQDGGSS CCEEECCCCCCCCCE | 31.75 | 19823750 | |
| 22 | Phosphorylation | VSGQDGGSSRIIGIN CCCCCCCCEEEEEEE | 23.21 | 24909858 | |
| 23 | Phosphorylation | SGQDGGSSRIIGINN CCCCCCCEEEEEEEC | 30.67 | 19823750 | |
| 31 | Phosphorylation | RIIGINNTESIDEDD EEEEEECCCCCCCCC | 26.99 | 21551504 | |
| 33 | Phosphorylation | IGINNTESIDEDDDD EEEECCCCCCCCCCC | 33.05 | 23607784 | |
| 47 | Phosphorylation | DDVLLDDSDNNTAKE CCCCCCCCCCCCCHH | 41.74 | 23749301 | |
| 51 | Phosphorylation | LDDSDNNTAKEEVEG CCCCCCCCCHHHHCC | 45.41 | 12736301 | |
| 62 | Phosphorylation | EVEGEEGSRKTHESK HHCCCCCCCCCCCCC | 33.61 | 19823750 | |
| 69 | Acetylation | SRKTHESKTVVVDDQ CCCCCCCCEEEECCC | 42.21 | 25381059 | |
| 70 | Phosphorylation | RKTHESKTVVVDDQG CCCCCCCEEEECCCC | 28.01 | 27214570 | |
| 86 | Acetylation | PRFTSASKTQGNKIK CCCCCCCCCCCCEEE | 44.58 | 25381059 | |
| 136 | Phosphorylation | RMNLKTKSVELRTNP EECCCCCEEEECCCC | 26.51 | 30377154 | |
| 144 | Acetylation | VELRTNPKFTTDPGA EEECCCCCCCCCHHH | 58.37 | 24489116 | |
| 154 | Ubiquitination | TDPGALQKGADFIKA CCHHHHHHCCCHHHH | 57.84 | 23749301 | |
| 188 | Acetylation | YIETFEVKDVKTLTG EEEEEEEECCCHHCC | 50.00 | 24489116 | |
| 208 | Acetylation | AIGRIAGKDGKTKFA HHHHHCCCCCCCEEE | 55.04 | 25381059 | |
| 246 | Phosphorylation | HIRMARESVVSLILG HHHCCCHHHHHHHHC | 23.43 | 28889911 | |
| 254 | Phosphorylation | VVSLILGSPPGKVYG HHHHHHCCCCCCCHH | 25.20 | 30377154 | |
| 268 | Phosphorylation | GNLRTVASRLKERY- HHHHHHHHHHHHHC- | 33.53 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PNO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PNO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PNO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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