| UniProt ID | NOB1_YEAST | |
|---|---|---|
| UniProt AC | Q08444 | |
| Protein Name | 20S-pre-rRNA D-site endonuclease NOB1 | |
| Gene Name | NOB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 459 | |
| Subcellular Localization | Cytoplasm. Nucleus, nucleolus. Endoplasmic reticulum. | |
| Protein Description | Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. In association with NIN1, may promote the recruitment of the proteasome to the ribosomal subunits stalled in maturation.. | |
| Protein Sequence | MTENQTAHVRALILDATPLITQSYTHYQNYAQSFYTTPTVFQEIKDAQARKNLEIWQSLGTLKLVHPSENSIAKVSTFAKLTGDYSVLSANDLHILALTYELEIKLNNGDWRLRKKPGDALDASKADVGTDGKQKLTEDNKKEEDSESVPKKKNKRRGGKKQKAKREAREAREAENANLELESKAEEHVEEAGSKEQICNDENIKESSDLNEVFEDADDDGDWITPENLTEAIIKDSGEDTTGSLGVEASEEDRHVALNRPENQVALATGDFAVQNVALQMNLNLMNFMSGLKIKRIRNYMLRCHACFKIFPLPKDGKPKHFCASCGGQGTLLRCAVSVDSRTGNVTPHLKSNFQWNNRGNRYSVASPLSKNSQKRYGKKGHVHSKPQENVILREDQKEYEKVIKQEEWTRRHNEKILNNWIGGGSADNYISPFAITGLKQHNVRIGKGRYVNSSKRRS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 124 | Phosphorylation | PGDALDASKADVGTD CCCCCCHHHCCCCCC | 28.22 | 30377154 | |
| 141 | Acetylation | QKLTEDNKKEEDSES CCCCCCCCCCCCCCC | 74.10 | 25381059 | |
| 146 | Phosphorylation | DNKKEEDSESVPKKK CCCCCCCCCCCCCHH | 34.74 | 27717283 | |
| 148 | Phosphorylation | KKEEDSESVPKKKNK CCCCCCCCCCCHHCC | 47.90 | 28889911 | |
| 183 | Phosphorylation | NANLELESKAEEHVE HHHCHHHHHHHHHHH | 50.19 | 29688323 | |
| 194 | Phosphorylation | EHVEEAGSKEQICND HHHHHHCCHHHHCCC | 39.81 | 27214570 | |
| 244 | Phosphorylation | SGEDTTGSLGVEASE CCCCCCCCCCCCCCH | 21.62 | 27214570 | |
| 338 | Phosphorylation | TLLRCAVSVDSRTGN EEEEEEEEECCCCCC | 11.15 | 28889911 | |
| 347 | Phosphorylation | DSRTGNVTPHLKSNF CCCCCCCCCCCHHHC | 14.70 | 27214570 | |
| 351 | Acetylation | GNVTPHLKSNFQWNN CCCCCCCHHHCCCCC | 40.08 | 24489116 | |
| 364 | Phosphorylation | NNRGNRYSVASPLSK CCCCCCEEECCCCCC | 14.15 | 28889911 | |
| 367 | Phosphorylation | GNRYSVASPLSKNSQ CCCEEECCCCCCCCH | 24.99 | 28152593 | |
| 370 | Phosphorylation | YSVASPLSKNSQKRY EEECCCCCCCCHHHH | 32.92 | 28889911 | |
| 371 | Acetylation | SVASPLSKNSQKRYG EECCCCCCCCHHHHC | 69.19 | 25381059 | |
| 402 | Ubiquitination | EDQKEYEKVIKQEEW CCHHHHHHHHCHHHH | 48.65 | 22817900 | |
| 405 | Acetylation | KEYEKVIKQEEWTRR HHHHHHHCHHHHHHH | 55.43 | 25381059 | |
| 405 | Ubiquitination | KEYEKVIKQEEWTRR HHHHHHHCHHHHHHH | 55.43 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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