YKC3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YKC3_YEAST
• UniProt AC: P36103
• Protein Name: Uncharacterized protein YKL023W
• Gene Name: YKL023W
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 277
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MNKEELLGFLLDDSIDSQKRCVTDQQAYSNWLKNDNDERTAHEESSSQSTIAALNKKKQTEAAQEDIEELLNGLEGIIGGADPRNLKSKSKRKTKKGGSKPREENVNTEKHIVMLEVEDFSDMSTHEDVNGASPSPNLDRSKKNEKRRKNAKELSYDELKDKLEVTTRKSRLECKDLKKKVHGLERRNLELEQRLEELKIENQTLIEINNKLLKNTNEDEINKSQRNKEKDRKRRERRTARRKDERKQEKKQEKKQDNKTSQSFPSSTDMNGQPIEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LGFLLDDSIDSQKRC HHHHHCCCCCCCCCC	28.14	28889911
47	Phosphorylation	TAHEESSSQSTIAAL CCCHHHCHHHHHHHH	37.11	28889911
121	Phosphorylation	MLEVEDFSDMSTHED EEEECCCCCCCCCCC	44.73	24961812
124	Phosphorylation	VEDFSDMSTHEDVNG ECCCCCCCCCCCCCC	31.44	24961812
125	Phosphorylation	EDFSDMSTHEDVNGA CCCCCCCCCCCCCCC	23.73	24961812
141	Phosphorylation	PSPNLDRSKKNEKRR CCCCCCHHHHHHHHH	47.88	27017623
162	Acetylation	SYDELKDKLEVTTRK CHHHHHHHHHHCCHH	44.98	24489116
224	Phosphorylation	NEDEINKSQRNKEKD CHHHHCHHHHHHHHH	29.86	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YKC3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YKC3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRP40_YEAST	SRP40	physical	11283351
YRA1_YEAST	YRA1	physical	16554755
RRS1_YEAST	RRS1	physical	16554755
LSM1_YEAST	LSM1	genetic	17314980
XRN1_YEAST	XRN1	genetic	17314980
LSM6_YEAST	LSM6	genetic	17314980
SSB1_YEAST	SSB1	physical	19536198
SPC72_YEAST	SPC72	physical	22875988
SPR3_YEAST	SPR3	physical	22875988
ETP1_YEAST	ETP1	physical	22875988
RNA1_YEAST	RNA1	physical	22875988

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-47, AND MASSSPECTROMETRY.
PubMed: 18407956